Neuropsychiatric symptoms are one of the factors determining quality of life among Parkinson's disease patients, but often remain underestimated by clinicians, especially in early disease stage. Objective: to study the clinical features of affective disorders and comorbid personality traits in prodrome of Parkinson's disease (PD) and their effect on treatment adherence. Materials and methods: 29 patients with PD were studied with questionnaires (Toronto alexithymia scale (TAS); Minimult personal questionnaire; DSM-IV criteria (SCID-II); Hospital anxiety and depression scale (HADS); Hamilton Scale for the Assessment of Depression (HAM-D)), and clinical-psychopathological method with objective information collection, neurological examination and neuropsychological testing. Results: Among the patients with PD, personality premorbid features cluster C were most prominent (48% patients). Affective disorders in the prodromal period of PD are dysthymia (13.7%); cyclothymia (6.8%); recurrent depressive disorder (34.4%); and single depressive episode (44.8%). Affective disorders in PD are characterized by late onset, the prevalence of anxiety, asthenic-apathetic symptoms, as well as a high level of alexithymia and somatization. We found the relationship of personality traits and adherence to therapy: the least compliant are histrionic n = 3 (10.3%) and schizotypal n = 2 (6.9%) patients. A high prevalence of dissociative reactions (55%) was noted in response to a diagnosis of PD, which is similar to cancer patients.