Low familial risks for multiple sclerosis in Buenos Aires, Argentina

Farez, Mauricio; Aguirre, María E. Balbuena; Varela, Francisco J.; Kohler, Alejandro; Nagel, Vanesa; Correale, Jorge

doi:10.1016/j.jns.2014.09.004

Cited by 13 publications

(10 citation statements)

References 25 publications

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“…It is an inflammatory autoimmune demyelinating disorder of the central nervous system resulting from a combination of genetic and environmental factors [ 3 ]. It mostly presents during 20 to 50 years of age, although there are special cases of MS presentation in pediatric and older ages [ 2 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Increasing prevalence of familial recurrence of multiple sclerosis in Iran: a population based study of Tehran registry 1999–2015

et al. 2018

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BackgroundTehran is the capital of Iran with an increasing multiple sclerosis (MS) prevalence. A retrospective population-based study was conducted to evaluate the trends of MS prevalence in Tehran.MethodsA population-based survey was conducted for the period 1999 to 2015, based on Iranian MS Society (IMSS) registry system of Tehran, the capital city of Iran. Point regression analysis was applied on MS trend data to find annual percent change (APC).The logistic regression analysis was used to estimate the odds ratio (OR) for individual variables in order to assess factors associating with familial recurrence of MS. P values < 0.05 were considered significant.ResultsMS prevalence has significantly increased during the study period from 1999 to 2015 (56.22 per 100,000). Total point prevalence of MS was 115.94 per 100,000 persons in 2015 compared to general population. Positive family history of MS was observed among 12.4% of patients. The strongest association amongst first-degree relatives was found in siblings, p value ≤ 0.001.ConclusionMS prevalence is rising in Tehran and this city is one of the regions with highest MS prevalence in Asia. In this sample, the largest proportion of relatives with MS were found among first-degree relatives, particularly siblings. Familial recurrence correlated with relative type.

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Section: Introductionmentioning

confidence: 99%

“…Familial recurrence studies in MS are useful to identify the correlated effects of genes and environment in the etiology of the disease [ 9 ]. Familial recurrence association is one of the strongest identified factors in MS, with the increased risk of MS presentation in offspring, siblings, and parents [ 3 , 10 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

Increasing prevalence of familial recurrence of multiple sclerosis in Iran: a population based study of Tehran registry 1999–2015

et al. 2018

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“…In Europe, MS prevalence has a higher rate in northern countries (3,14). Familial incidence of MS is low in places like Hong Kong (41) and Argentina (42).…”

Section: Discussionmentioning

confidence: 99%

Frequency of Multiple Sclerosis (MS) Among Relatives of MS Patients in Hamadan Society, Iran

Mazdeh

Khazaei

Hashemi-Firouzi

et al. 2016

Avicenna J Neuro Psycho Physiology

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Background: Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system with unknown causes. In the last decade, the prevalence of MS in Iran has increased. Objectives: This study evaluated the frequency of familial MS among patients in the Hamadan society for MS. Patients and Methods: This cross-sectional study was performed on 1202 MS patients in Farshchian hospital, Hamadan, in 2013. All patients were diagnosed with definite MS. A questionnaire was used to gather information; demographic characteristics, medical history, signs and symptoms at onset, course of disease, relatives with MS, and degree and type of relationship were recorded.

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“…MS is a provocative disease distinguished by losing the myelin sheath of neurons in the central nervous system (22). Many factors such as environmental and genetic factors may play important role in developing MS (23). Susceptibility to develop MS and its association with MOB has been confirmed in some studies (10).…”

Section: Discussionmentioning

confidence: 99%

Scattering Month and Day of Baby Delivery in a Retrospective Survey Linked to 1484 Patients With Multiple Sclerosis

Tolou-Ghamari

2015

Arch Neurosci

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Background: Multiple Sclerosis (MS) is an inflammatory demyelinating disease leading to formation of brain lesions that could produce numerous devastating clinical problems. There are controversial reports related to the type of association of MS with the seasons of birth. Objectives: This study aimed to rank and describe the effect of different months and days of birth on MS. Patients and Methods: The study was conducted in Isfahan University of Medical Sciences, Isfahan, Iran. A total of 1484 patients with MS were included: 1111 females and 373 males. Demographic and clinical data were recorded in a database and were analyzed using SPSS. Results: The population of females with MS had surpassed that of males (75% vs. 25%). The mean age of patients was 34.7 years (range from 7 to 88 years) with 85% of population being younger than 50 years old. The season of birth was winter in 21% of patients. There was a decreased risk of MS in those born in February and March. The prevalence of MS increased from April and reached a peak in May and September. Day of birth was associated with the birthday on 19th day of month in 44% of patients. Conclusions: This investigation supports earlier reports of increased and diminished prevalence of MS in those born in the spring and winter months, respectively. Pharmacotherapy using vitamin D might have beneficial effect in Iranian population, especially in females during pregnancy and their newborns. Therefore, further clinical researches focused on prescription of vitamin D, genetic, daily photoperiod, and geo-epidemiologic differences of disease are recommended.

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Low familial risks for multiple sclerosis in Buenos Aires, Argentina

Cited by 13 publications

References 25 publications

Increasing prevalence of familial recurrence of multiple sclerosis in Iran: a population based study of Tehran registry 1999–2015

Increasing prevalence of familial recurrence of multiple sclerosis in Iran: a population based study of Tehran registry 1999–2015

Frequency of Multiple Sclerosis (MS) Among Relatives of MS Patients in Hamadan Society, Iran

Scattering Month and Day of Baby Delivery in a Retrospective Survey Linked to 1484 Patients With Multiple Sclerosis

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