Frequency of Multiple Sclerosis (MS) Among Relatives of MS Patients in Hamadan Society, Iran

Mazdeh, Mehrdokht; Khazaei, Mojtaba; Hashemi-Firouzi, Nasrin; Ghiasian, Masoud

doi:10.17795/ajnpp-38613

Cited by 5 publications

(2 citation statements)

References 53 publications

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“…In this regard, cohort studies could be well suited on the account of a longer time period for the accumulation of new cases in the family. Concerning the degree of relatedness, the occurrence of the same condition is more prevalent in rst-degree relatives, particularly siblings of the affected individuals, which underscores the combined role of shared genetic and environmental factors in MS etiology [16,24,25,29,33,34]. While, one study reported parent-child relationship as the prevalent kinship [28].…”

Section: Discussionmentioning

confidence: 99%

“…In this context, the probability of the transmission of disease from mother to child is more than father to child [13,8,58]. Amongst the siblings, sister-sister, sister-brother, and brother-brother relation are, respectively, more prevalent [29,34]. Evidently, after rst-degree relatives, third-degree relatives have more chance for the development of MS [13,18,34].…”

Section: Discussionmentioning

confidence: 99%

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The global prevalence of familial multiple sclerosis: an updated systematic review and meta-analysis

Ehtesham

Rafie

Mosallaei

2021

Preprint

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Background: Considering that familial multiple sclerosis (FMS) can reveal the extent to which genetic and environmental factors each involve in the etiopathogenesis of the disease, we performed an updated meta-analysis of the worldwide prevalence of FMS by addition of recent publications. Methods: A search in PubMed, Scopus, the ISI Web of Science, and Google Scholar up to 20 December 2020 was done. The inclusion criteria were based on the CoCoPop approach (condition, context, and population). The qualified studies entered the process of the meta-analysis by using comprehensive meta-analysis ver. 2 software.Results: The pooled prevalence of MS in relatives of 16179 FMS cases was estimated to be 11.8% (95% CI: 10.7-13) based on a random-effects model. The pooled mean age of disease onset in adult probands was calculated to be 28.7 years (95% CI: 27.2± 30.2). In 13 studies that reported the data of FMS in pediatrics (n=6636) and adults (n=877), the FMS prevalence was 10.8% (95% CI: 8.1-14.2) and 15.5% (95% CI: 13.8-17.4), respectively. Considering the data of 9 studies, the prevalence of FMS in males (n=5243) and females (n=11503) patients was calculated to be 13.7% (95% CI: 10.1-18.2) and 15.4% (95% CI: 10.3-22.4), respectively. The odds ratio of male/female in FMS cases was not statistically significant (OR= 0.9; 95% CI: 0.6-1.2, P=0.55). Subgroup analysis demonstrated a significant difference in the prevalence of FMS between the geographical areas (P= 0.007). The meta-regression model for FMS prevalence was significantly lower in terms of higher latitude (P< 0.001) and increased MS prevalence (P< 0.001). In contrast, meta-regression based on prevalence day was not statistically significant (P=0.29).Conclusions: The prevalence of FMS is more in the pediatric group than that of adults, is distinct between geographical areas, and diminishes with the increment of MS prevalence and latitude. Also, the symptoms initiate relatively at lower ages in FMS cases. By contrast with multifactorial diseases, our analysis unveiled that the prevalence of FMS was not more prevalent in men than women and the risk of MS development in relatives was not more when the affected proband was male.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The global prevalence of familial multiple sclerosis: an updated systematic review and meta-analysis

Ehtesham

Rafie

Mosallaei

2021

Preprint

View full text Add to dashboard Cite

show abstract

Epidemiology of familial multiple sclerosis: A population-based study in Tehran during 1999–2018

Salehi

Almasi‐Hashiani

Sahraian

et al. 2020

Multiple Sclerosis and Related Disorders

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The global prevalence of familial multiple sclerosis: an updated systematic review and meta-analysis

2021

View full text Add to dashboard Cite

Background Considering that many recent studies have reported the prevalence of familial multiple sclerosis (FMS), we performed an updated meta-analysis of the worldwide prevalence of FMS by the addition of recent publications. Methods A search in PubMed, Scopus, the ISI Web of Science, and Google Scholar was undertaken up to 20 December 2020. The inclusion criteria were based on the CoCoPop approach (condition, context, and population). Meta-analysis of the qualified studies was conducted by comprehensive meta-analysis ver. 2 software. Results The pooled prevalence of MS in relatives of 16,179 FMS cases was estimated to be 11.8% (95% CI: 10.7–13) based on a random-effects model. The pooled mean age of disease onset in adult probands was calculated to be 28.7 years (95% CI: 27.2 ± 30.2). Regarding 13 studies that reported the data of FMS in pediatrics (n = 877) and adults (n = 6636), the FMS prevalence in pediatrics and adults was 15.5% (95% CI: 13.8–17.4) and 10.8% (95% CI: 8.1–14.2), respectively. The prevalence of FMS in affected males (n = 5243) and females (n = 11,503) was calculated to be 13.7% (95% CI: 10.1–18.2) and 15.4% (95% CI: 10.3–22.4), respectively. The odds ratio of male/female in FMS cases was not statistically significant (OR = 0.9; 95% CI: 0.6–1.2, P = 0.55). Subgroup analysis demonstrated a significant difference in the prevalence of FMS between the geographical areas (P = 0.007). The meta-regression model indicated that the prevalence of FMS is lower with higher latitude and higher MS prevalence (P < 0.001). In contrast, meta-regression based on prevalence day was not statistically significant (P = 0.29). Conclusions The prevalence of FMS is higher in the pediatric group than that of adults, distinct between geographical areas, and diminishes with the increment of MS prevalence and latitude. Also, the symptoms initiate relatively at younger ages in the FMS cases. Interestingly, our analysis unveiled that FMS is not more prevalent in men than women and the risk of MS development in relatives is not higher when the affected proband is male.

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Frequency of Multiple Sclerosis (MS) Among Relatives of MS Patients in Hamadan Society, Iran

Cited by 5 publications

References 53 publications

The global prevalence of familial multiple sclerosis: an updated systematic review and meta-analysis

The global prevalence of familial multiple sclerosis: an updated systematic review and meta-analysis

Epidemiology of familial multiple sclerosis: A population-based study in Tehran during 1999–2018

The global prevalence of familial multiple sclerosis: an updated systematic review and meta-analysis

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