Low Expression of Junctional Adhesion Molecule A Is Associated with Metastasis and Poor Survival in Pancreatic Cancer

Fong, Dominic; Spizzo, Gilbert; Mitterer, Manfred; Seeber, Andreas; Steurer, Michael; Gastl, Guenther; Brosch, Ines; Moser, Patrizia

doi:10.1245/s10434-012-2381-8

Cited by 40 publications

(47 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, it was reported that knock-down of JAM-A induced renal cancer cells migration [19]. These inconsistent results may suggest that aberrant expression of JAM-A in cancers may be involved in different signaling pathways, which lead to different effects of JAM-A on regulating cancer cells migration and invasion [7]. Therefore, further studies are needed to clarify the molecular mechanisms involved in the JAM-A-induced inhibition of gastric cancer cells migration and invasion in the future, which is helpful for further understanding the role of JAM-A in gastric cancer progression.…”

Section: Discussionmentioning

confidence: 99%

“…Antigen expression was defined as the presence of specific staining on surface membranes of tumor cells [7]. The evaluation was based on the staining intensity and extent of staining.…”

Section: 4mentioning

confidence: 99%

“…Membranous JAM-A staining was scored low or high. Low JAM-A expression was defined as a total score of 4 [7]. The plasmid of pEGFP-N1-JAM-A, which encodes JAM-A, was purchased from GeneChem (Shanghai, China).…”

Section: 4mentioning

confidence: 99%

“…However, the prognostic value of JAM-A expression in different cancers is highly inconsistent. In pancreatic cancer and endometrial carcinoma, low JAM-A expression has been showed to correlate with poor prognosis [7,8]. On the contrary, in lung cancer and breast cancer, a positive correlation between high JAM-A expression and poor survival has been reported [5,6].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Low junctional adhesion molecule A expression correlates with poor prognosis in gastric cancer

Huang¹,

Xu²,

Sun³

et al. 2014

Journal of Surgical Research

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

“…Antigen expression was defined as the presence of specific staining on surface membranes of tumor cells [7]. The evaluation was based on the staining intensity and extent of staining.…”

Section: 4mentioning

confidence: 99%

Section: 4mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Low junctional adhesion molecule A expression correlates with poor prognosis in gastric cancer

Huang¹,

Xu²,

Sun³

et al. 2014

Journal of Surgical Research

View full text Add to dashboard Cite

“…In breast cancer cells it was originally thought that attenuation of JAM-A either directly (25) or by upstream regulation of transforming growth factor-β1 expression (26) contributed to invasive potential. In pancreatic cancer low expression of JAM-A has been associated with metastasis and poor patient survival (27), while downregulation of JAM-A has also been linked with clear renal cell carcinoma (28). It will be interesting to determine in future studies whether JAM-A represents merely a biomarker in some cancers versus a viable therapeutic target in others.…”

Section: Junctional Adhesion Molecules (Jams)mentioning

confidence: 99%

The Contribution of Ig-Superfamily and MARVEL D Tight Junction Proteins to Cancer Pathobiology

et al. 2016

View full text Add to dashboard Cite

Word count (abstract-conclusion inclusive) = 4,1252 AbstractThe epithelial linings of eukaryotic organs form dynamically-regulated selectively-permeable barriers that control the movement of substances into (and out of) mucosal tissues. The principal structural determinants of epithelial barrier function are intercellular tight junctions (TJs), multi-protein complexes composed of claudin and non-claudin transmembrane proteins in addition to cytosolic linker proteins. As well as their crucial roles in barrier function, it is now well recognized that TJ proteins coordinate a variety of signaling and trafficking functions regulating physiological events such as cell differentiation, proliferation, migration and polarity. Accordingly, dysregulations in TJ protein expression or function are increasingly being linked to several pathophysiologies including cancer. To date, claudins have received the most attention as putative contributors to cancer initiation or progression.However the contribution of non-claudin transmembrane TJ proteins (including select immunoglobulin superfamily members, nectins, occludin and Marvel D family members) to the pathophysiology of cancer remains incompletely understood. Therefore the focus of this review is to collate recently-published evidence that supports or discounts a role for nonclaudin transmembrane TJ proteins in cancer, and to speculate upon the feasibility of these molecules as prognostic biomarkers or therapeutic targets in cancer.3

show abstract

Identify potential clinical significance of long noncoding RNA forkhead box P4 antisense RNA 1 in patients with early stage pancreatic ductal adenocarcinoma

Liu

Chen

et al. 2020

Cancer Medicine

View full text Add to dashboard Cite

Previous studies have shown that forkhead box P4 antisense RNA 1 (FOXP4‐AS1) is dysregulated in tumor tissues and can serve as a prognostic indicator for multiple cancers. However, the clinical significance of FOXP4‐AS1 in pancreatic ductal adenocarcinoma (PDAC) remains unclear. The goal of this study is to recognize the possible clinical significance of long noncoding RNA FOXP4‐AS1 in patients with early stage PDAC. A total of 112 patients from The Cancer Genome Atlas (TCGA) PDAC cohort, receiving RNA sequencing, were involved in the study. Survival analysis, functional mechanism, and potential small molecule drugs of target therapy of FOXP4‐AS1 were performed in this study. Survival analysis in TCGA PDAC cohort suggested that patients with high FOXP4‐AS1 expression had significantly augmented possibility of death than in PDAC patients with lower FOXP4‐AS1 expression (adjusted P = .008; adjusted HR = 2.143, 95% CI = 1.221‐3.760). In this study, a genome‐wide RNA sequencing dataset was used to identify 927 genes co‐expressing with FOXP4‐AS1 in PDAC tumor tissues. A total of 676 differentially expressed genes were identified between different FOXP4‐AS1 expression groups. Functional enrichment analysis of these genes and gene set enrichment analysis for PDAC genome‐wide RNA sequencing dataset was done. We have found that FOXP4‐AS1 may function in PDAC by participating in biological processes and pathways including oxidative phosphorylation, tricarboxylic acid cycle, classical tumor‐related pathways such as NF‐kappaB as well as Janus kinase/signal transducers in addition to activators of transcription, cell proliferation, and adhesion. In addition, we also screened two potential targeted therapeutic small molecule drugs (dimenhydrinate and metanephrine) for FOXP4‐AS1 in PDAC. In conclusion, our present study demonstrated that higher expression of FOXP4‐AS1 in PDAC tumor tissues were related with an inferior medical outcome. Through multiple genome‐wide approaches, we identified the potential molecular mechanisms of FOXP4‐AS1 in PDAC and two targeted therapeutic drugs for it.

show abstract

Low Expression of Junctional Adhesion Molecule A Is Associated with Metastasis and Poor Survival in Pancreatic Cancer

Abstract: These findings suggest for the first time that low levels of JAM-A expression in pancreatic cancer are associated with poor clinical outcome. JAM-A may represents a target molecule for functional inactivation and serve as a novel biomarker of adverse prognosis in pancreatic cancer.

Cited by 40 publications

References 36 publications

Low junctional adhesion molecule A expression correlates with poor prognosis in gastric cancer

Low junctional adhesion molecule A expression correlates with poor prognosis in gastric cancer

The Contribution of Ig-Superfamily and MARVEL D Tight Junction Proteins to Cancer Pathobiology

Identify potential clinical significance of long noncoding RNA forkhead box P4 antisense RNA 1 in patients with early stage pancreatic ductal adenocarcinoma

Contact Info

Product

Resources

About