Low junctional adhesion molecule A expression correlates with poor prognosis in gastric cancer

Huang, Jinyu; Xu, Yingying; Sun, Zhe; Wang, Zhenning; Zhu, Zhi; Song, Yongxi; Luo, Yanhong; Zhang, Xue; Xu, Hui

doi:10.1016/j.jss.2014.06.025

Cited by 31 publications

(30 citation statements)

References 19 publications

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“…Furthermore, low JAM-A expression has been shown to correlate with poor prognosis in pancreatic, 22 endometrial, 23 and gastric cancer. 24 However, it has been proposed that aberrant TJ protein expression, not only TJ protein loss, could contribute to tumorigenesis. 14 To the best of our knowledge, this is the first study investigating the role of JAM-A gene expression in EOC.…”

Section: Discussionmentioning

confidence: 99%

High expression of junctional adhesion molecule-A is associated with poor survival in patients with epithelial ovarian cancer

et al. 2019

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Purpose: Aberrant expression of different tight junction proteins, including the junctional adhesion molecule-A (JAM-A), has been frequently reported in association with tumor progression of several malignancies. To our knowledge, this is the first study examining the clinical significance of JAM-A gene expression in epithelial ovarian cancer. Methods: JAM-A expression levels in 44 epithelial ovarian cancer and 12 benign formalin-fixed paraffin-embedded samples were determined by reverse transcription quantitative polymerase chain reaction. Receiver operating characteristic (ROC) curve analysis was used to determine the diagnostic and prognostic potential of JAM-A. Associations between JAM-A expression and clinicopathological characteristics of epithelial ovarian cancer were analyzed using Fisher’s exact test. The Kaplan–Meier method and univariate Cox regression analysis were used for the survival analysis. P ⩽ 0.05 was considered statistically significant. Results: ROC curve analyses showed that JAM-A gene expression exhibits both diagnostic and prognostic performance in epithelial ovarian cancer (area under the curve (AUC) 0.640, 95% confidence interval (CI) 0.488, 0.792, sensitivity 43.18%, specificity 100% and AUC 0.621, 95% CI 0.427, 0.816, sensitivity 52.63%, specificity 85%, respectively). JAM-A expression was significantly associated with International Federation of Gynecologists and Obstetricians (FIGO) stage ( P =0.049) and the Kaplan–Meier method demonstrated that patients with high expression of JAM-A had significantly worse overall survival compared to patients with low JAM-A expression ( P =0.004). Moreover, univariate Cox regression analysis showed that FIGO stage, peritoneal metastasis, residual tumor and JAM-A expression were significantly associated with reduced overall survival in epithelial ovarian cancer. Conclusions: Our results indicate that high levels of JAM-A expression are associated with an advanced clinicopathological feature and may have diagnostic potential; also, it could be a predictor of poor overall survival in patients with epithelial ovarian cancer.

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Section: Discussionmentioning

confidence: 99%

High expression of junctional adhesion molecule-A is associated with poor survival in patients with epithelial ovarian cancer

et al. 2019

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“…7 Consistent with our findings in thyroid cancer, JAM-A is downregulated in pancreatic, 9 renal, 10 and gastric cancers. 11 On the contrary, JAM-A is overexpressed in nasopharyngeal cancers, 3 head and neck squamous cell carcinoma, 12 non-small-cell lung cancer, 13 and in multiple myeloma. 14 Specific signal pathways deregulated in thyroid cancer might mediate the loss of JAM-A in ATC.…”

Section: Discussionmentioning

confidence: 99%

“…JAM‐A is deregulated in several human carcinomas, in particular, its low expression is associated with poor prognosis in pancreatic, renal, and gastric cancers . On contrary, recent papers report high expression levels of JAM‐A in nasopharyngeal cancers, head and neck squamous cell carcinoma, non–small‐cell lung cancer, and in multiple myeloma …”

Section: Introductionmentioning

confidence: 99%

Junctional adhesion molecule‐A is down‐regulated in anaplastic thyroid carcinomas and reduces cancer cell aggressiveness by modulating p53 and GSK3 α/β pathways

Orlandella

Mariniello

Iervolino

et al. 2019

Molecular Carcinogenesis

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Junctional adhesion molecule A (JAM‐A) is a transmembrane protein that contributes to different biological process, including the epithelial to mesenchymal transition (EMT). Through an EMT profiler array, we explored the molecular players associated with human thyroid cancer progression and identified JAM‐A as one of the genes mostly deregulated. The quantitative real‐time polymerase chain reaction and immunohistochemistry analyses showed that downregulation of JAM‐A occurred in anaplastic thyroid carcinoma (ATC) compared with normal thyroid (NT) and papillary thyroid carcinoma (PTC) tissues and correlated with extrathyroid infiltration, tumor size, and ATC histotype. In ATC cell lines, JAM‐A restoration suppressed malignant hallmarks of transformation including cell proliferation, motility, and transendothelial migration. Accordingly, knockdown of JAM‐A enhanced thyroid cancer cell proliferation and motility in PTC cells. Through the proteome profiler human phospho‐kinase array, we demonstrated that higher expression of JAM‐A was associated with a significant increased level of phosphorylation of p53 and GSK3 α/β proteins. In conclusion, our findings highlight a novel role of JAM‐A in thyroid cancer progression and suggest that JAM‐A restoration could have potential clinical relevance in thyroid cancer treatment.

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“…23 Moreover, low JAM-A expression was significantly associated with tumor size, lymphatic vessel invasion, lymph node metastasis, TNM stage, and poor survival in gastric cancer patients and promoted cell migration and invasion. 24 Recently, it was shown that the silencing of JAM-A protein expression in breast cancer cells significantly reduces breast cancer cell adhesion and migration 9 due to JAM-A functions in promoting epithelial cell spreading 5 and leukocyte migration. 7 It has been also shown that signaling events resulting with high JAM-A expression may promote the migration of breast tumor cells associated with tumor invasion and metastasis.…”

Section: Discussionmentioning

confidence: 99%

Interactive Effects of Common Haplotypes of Two Leukocyte Diapedesis-Related Genes, LFA-1 and JAM-A on Breast Cancer Risk

Yilmaz-Aydogan¹

2018

UHOD

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Leukocyte diapedesis is an important process in breast cancer etiopathogenesis. Therefore, Junctional adhesion molecule-A (JAM-A) and lymphocyte function-associated antigen-1 (LFA-1) genes are among potential candidate genes involved in breast cancer development. In the present study, JAM-A rs790056 (T>C), LFA-1 rs8058823 (A>G) and LFA-1 rs2230433 (C>G) gene variations and their associations with breast cancer risk were investigated in breast cancer patients and healthy subjects. The JAM-A and LFA-1 genotypes were determined in 108 breast cancer patients and 63 healthy controls with Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) assay. LFA-1 rs8058823 common AA genotype (χ 2 = 6.062, p= 0.014) and A allele frequency (p= 0.001) and LFA-1 rs2230433 rare GG genotype frequency (p= 0.048) was higher in the patient group compared with controls. The TA haplotype (JAM-A rs790056-T, LFA-1 rs8058823-A alleles) frequency was significantly increased in the patient group compared with controls (p= 0.0173), while the TG haplotype (JAM-A rs790056-T, LFA-1 rs8058823-G alleles) and CG haplotype (LFA-1 rs2230433-C, LFA-1 rs8058823-G alleles) frequencies were significantly lower in the patient group compared with controls (p= 0.0051 and p= 0.002, respectively). In addition, the TCG haplotype (JAM-A rs790056-T, LFA-1 rs2230433-C, LFA-1 rs8058823-G alleles) frequency was significantly lower in the patient group compared with controls (p= 0.0096). Haplotype analysis confirmed that the LFA-1 rs8058823 is more effective in breast cancer risk than LFA-1 rs2230433 and JAM-A rs790056. LFA-1 rs8058823 A allele may be related to breast cancer risk, influencing leukocyte diapedesis. Our findings indicate that functional gene variations associated with leukocyte diapedesis may affect breast cancer risk.

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Low junctional adhesion molecule A expression correlates with poor prognosis in gastric cancer

Cited by 31 publications

References 19 publications

High expression of junctional adhesion molecule-A is associated with poor survival in patients with epithelial ovarian cancer

High expression of junctional adhesion molecule-A is associated with poor survival in patients with epithelial ovarian cancer

Junctional adhesion molecule‐A is down‐regulated in anaplastic thyroid carcinomas and reduces cancer cell aggressiveness by modulating p53 and GSK3 α/β pathways

Interactive Effects of Common Haplotypes of Two Leukocyte Diapedesis-Related Genes, LFA-1 and JAM-A on Breast Cancer Risk

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