Low etiologic fraction for high-risk human papillomavirus in oral cavity squamous cell carcinomas

Lingen, Mark W.; Xiao, Weihong; Schmitt, Alessandra C.; Jiang, Bo; Pickard, Robert K. L.; Kreinbrink, P.J.; Perez-Ordonez, Bayardo; Jordan, Richard C.; Gillison, Maura L.

doi:10.1016/j.oraloncology.2012.07.002

Cited by 306 publications

(286 citation statements)

References 25 publications

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“…We therefore report that p16 overexpression may not be a suitable surrogate marker for HPV infection in tongue cancers. Poor positive predictive value for detection of HPV infection by p16 expression has been reported earlier (Lewis et al, 2010;Lingen et al, 2013) similar to the current study. These results are also supported in large meta-analysis study reported in nonoropharyngeal cancers (Combes and Franceschi, 2014).…”

Section: Discussionsupporting

confidence: 91%

“…However a majority of the cases reported in this study were primaries from larynx and only 19 samples were from the oral cavity. However this may not be applicable to tongue cancers where we report poor positive predictive value for p16 in detection of HPV in oral tongue cancers, which is similar to reports of Lingen et al (Lingen et al, 2013).…”

Section: Discussionsupporting

confidence: 74%

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Risk Stratification of Early Stage Oral Tongue Cancers Based on HPV Status and p16 Immunoexpression

Ramshankar¹,

Soundara²,

Shyamsundar³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Recent epidemiological data have implicated human papilloma virus (HPV) infection in the pathogenesis of head and neck cancers, especially oropharyngeal cancers. Although, HPV has been detected in varied amounts in persons with oral dysplasia, leukoplakias and malignancies, its involvement in oral tongue carcinogenesis remains ambiguous. Materials and Methods: HPV DNA prevalence was assessed by PCR with formalin fixed paraffin embedded sections (n=167) of oral tongue squamous cell carcinoma patients and the physical status of the HPV16 DNA was assessed by qPCR. Immunohistochemistry was conducted for p16 evaluation. Results: We found the HPV prevalence in tongue cancers to be 51.2%, HPV 16 being present in 85.2% of the positive cases. A notable finding was a very poor concordance between HPV 16 DNA and p16 IHC findings (kappa<0.2). Further molecular classification of patients based on HPV16 DNA prevalence and p16 overexpression showed that patients with tumours showing p16 overexpression had increased hazard of death (HR=2.395; p=0.005) and disease recurrence (HR=2.581; p=0.002) irrespective of their HPV 16 DNA status. Conclusions: Our study has brought out several key facets which can potentially redefine our understanding of tongue cancer tumorigenesis. It has emphatically shown p16 overexpression to be a single important prognostic variable in defining a high risk group and depicting a poorer prognosis, thus highlighting the need for its routine assessment in tongue cancers. Another significant finding was a very poor concordance between p16 expression and HPV infection suggesting that p16 expression should possibly not be used as a surrogate marker for HPV infection in tongue cancers. Interestingly, the prognostic significance of p16 overexpression is different from that reported in oropharyngeal cancers. The mechanism of HPV independent p16 over expression in oral tongue cancers is possibly a distinct entity and needs to be further studied.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 74%

Risk Stratification of Early Stage Oral Tongue Cancers Based on HPV Status and p16 Immunoexpression

Ramshankar¹,

Soundara²,

Shyamsundar³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Over the last three decades, the high-risk HPV genotypes (hrHPV) have been confirmed as the major etiologic factor of the subset of oropharyngeal SCC, dominating in the western part of the world [14,15]. The significance of hrHPV infection in the development of tumours in oral cavity, hypopharynx and larynx needs to be additionally elucidated [1,2,[16][17][18]. Controversial data on hrHPV DNA prevalence in hypopharyngeal and laryngeal SCC has been published; prevalence varied considerably, from 5 to 60% [4,19,20].…”

Section: Etiopathogenesis Of Conventional Squamous Cell Carcinoma Sumentioning

confidence: 99%

Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: What is New in the 2017 WHO Blue Book for Tumours of the Hypopharynx, Larynx, Trachea and Parapharyngeal Space

Gale

Poljak

Zidar

2017

Head and Neck Pathol

124

113

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briefly discussed. The most important innovation is brought by the section on precursor lesions, in which a unified twotier classification, consisting of low-and high-grade dysplasia, is introduced. The proposed two-tier system can also be transformed into a three-tier classification for treatment purposes, with a distinction between carcinoma in situ and high-grade dysplasia. The reviewed morphological criteria of the proposed system are based on the amended Ljubljana classification. The section on laryngeal neuroendocrine carcinomas (NEC) represents a considerable improvement in terminology and classification. NEC are divided into well-, moderate-and poorly-differentiated neuroendocrine carcinoma. The latter is additionally divided into small cell NEC and large cell NEC (LCNEC). It is of extreme importance that LCNEC, which was associated in the WHO 2005 edition with atypical carcinoid/moderately differentiated neuroendocrine carcinoma, grade II, has now been transferred into the group of poorly differentiated NEC, grade III, displaying a specific morphology and poorer prognosis.

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“…Three subgroups of NSND with HNSCC have been described: young to middle-aged men with oropharyngeal SCC, young women with oral tongue SCC (OTSCC) and elderly women with gingival SCC [2]. Although human papillomavirus (HPV) has been associated with the increasing incidence of oropharyngeal cancer in young men over the past decades [3], it is not involved in oral carcinogenesis [4] and therefore, does not account for the increasing incidence of OTSCC in young women [5]. Moreover, recent studies have not yet identified any other potentially oncogenic virus in oral cavity [6].…”

Section: Introductionmentioning

confidence: 99%

The immune microenvironment of HPV-negative oral squamous cell carcinoma from never-smokers and never-drinkers patients suggests higher clinical benefit of IDO1 and PD1/PD-L1 blockade

et al. 2017

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To cite this version:P. Foy, Chloé Bertolus, Marie-Cécile Michallet, Sophie Deneuve, R. Incitti, et al.. The immune microenvironment of HPV-negative oral squamous cell carcinoma from never-smokers and never-drinkers patients suggests higher clinical benefit of IDO1 and PD1/PD-L1 blockade. Annals of Oncology, Oxford University Press (OUP), 2017, 28 (8), pp.1934-1941 Background: Never-smokers and never-drinkers patients (NSND) suffering from oral

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Low etiologic fraction for high-risk human papillomavirus in oral cavity squamous cell carcinomas

Cited by 306 publications

References 25 publications

Risk Stratification of Early Stage Oral Tongue Cancers Based on HPV Status and p16 Immunoexpression

Risk Stratification of Early Stage Oral Tongue Cancers Based on HPV Status and p16 Immunoexpression

Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: What is New in the 2017 WHO Blue Book for Tumours of the Hypopharynx, Larynx, Trachea and Parapharyngeal Space

The immune microenvironment of HPV-negative oral squamous cell carcinoma from never-smokers and never-drinkers patients suggests higher clinical benefit of IDO1 and PD1/PD-L1 blockade

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