Low doses of zeolitic imidazolate framework-8 nanoparticles alter the actin organization and contractility of vascular smooth muscle cells

Kota, Divya; Kang, Lin; Rickel, Alex P.; Liu, Jinyuan; Smith, Steve; Hong, Zhongkui; Wang, Congzhou

doi:10.1016/j.jhazmat.2021.125514

Cited by 24 publications

(21 citation statements)

References 78 publications

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“…NPs could cause non-migratory cells to migrate and develop diseases. For example, unlike non-migratory VSMSc cells, zeolitic imidazolate framework-8 (ZIF-8) NPtreated cells migrate and could cause cardiovascular disease [165]. The mechanical changes (Young's modulus) in cells could influence their migratory abilities.…”

Section: Impacts Of Nanoparticles On Migratory Ability Of Cellsmentioning

confidence: 99%

Cancer-Nano-Interaction: From Cellular Uptake to Mechanobiological Responses

Kashani

Packirisamy

2021

IJMS

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With the advancement of nanotechnology, the nano-bio-interaction field has emerged. It is essential to enhance our understanding of nano-bio-interaction in different aspects to design nanomedicines and improve their efficacy for therapeutic and diagnostic applications. Many researchers have extensively studied the toxicological responses of cancer cells to nano-bio-interaction, while their mechanobiological responses have been less investigated. The mechanobiological properties of cells such as elasticity and adhesion play vital roles in cellular functions and cancer progression. Many studies have noticed the impacts of cellular uptake on the structural organization of cells and, in return, the mechanobiology of human cells. Mechanobiological changes induced by the interactions of nanomaterials and cells could alter cellular functions and influence cancer progression. Hence, in addition to biological responses, the possible mechanobiological responses of treated cells should be monitored as a standard methodology to evaluate the efficiency of nanomedicines. Studying the cancer-nano-interaction in the context of cell mechanics takes our knowledge one step closer to designing safe and intelligent nanomedicines. In this review, we briefly discuss how the characteristic properties of nanoparticles influence cellular uptake. Then, we provide insight into the mechanobiological responses that may occur during the nano-bio-interactions, and finally, the important measurement techniques for the mechanobiological characterizations of cells are summarized and compared. Understanding the unknown mechanobiological responses to nano-bio-interaction will help with developing the application of nanoparticles to modulate cell mechanics for controlling cancer progression.

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Section: Impacts Of Nanoparticles On Migratory Ability Of Cellsmentioning

confidence: 99%

Cancer-Nano-Interaction: From Cellular Uptake to Mechanobiological Responses

Kashani

Packirisamy

2021

IJMS

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“…Bismuth is a classical semimetallic element and a hot spot of scientific research (33,34) because it is cheap and non-toxic (35). Most ZIF-8 nanodrug carriers are used for intravenous drug delivery, and are considered to be promising drug release and controlled release platforms (36). Jinghua Li et al combined Bi and ZIF-8 through a one-step reduction method (Bi@ZIF-8), added gambogic acid to Bi@ZIF-8 to form Bi@ZIF-8-gambogic acid (GBZ), while gambogic acid could be an inhibitor of Hsp90.…”

Section: Ptt Ptt For Hccmentioning

confidence: 99%

Photodynamic and Photothermal Therapy of Hepatocellular Carcinoma

2021

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Hepatocellular carcinoma (HCC) is the most common primary liver tumor. It is ranked the sixth most common neoplasm and the third most common cause of cancer mortality. At present, the most common treatment for HCC is surgery, but the 5-year recurrence rates are still high. Patients with early stage HCC with few nodules can be treated with resection or radiofrequency ablation (RFA); while for multinodular HCC, transarterial chemoembolization (TACE) has been the first-line treatment. In recent years, based on medical engineering cooperation, nanotechnology has been increasingly applied to the treatment of cancer. Photodynamic therapy and photothermal therapy are effective for cancer. This paper summarizes the latest progress of photodynamic therapy and photothermal therapy for HCC, with the aim of providing new ideas for the treatment of HCC.

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“…MUC18 immunostaining protocol of cells was following our previous publication. 3 Human MCAM/MUC18 Alexa Fluor 594 conjugated antibody was from R&D system. For the competition assay, the cells were treated with free MUC antibodies in culture media for 30 min and washed, followed by incubation with PDA@MUC18Ab for 12 h before DIC imaging.…”

Section: Dic Imaging and Muc18 Immunostainingmentioning

confidence: 99%

“…Instrumentation details for dSTORM imaging, and the components for cytoskeletal buffer and imaging buffer can be found in our earlier publication. 3 Different from conventional epifluorescence microscopy, dSTORM implements a total internal reflection illumination, making sure only fluorophores 100-200 nm above the cover glass are efficiently excited, thereby eliminating the background fluorescence outside the focal plane. The data was processed through ImageJ and ThunderSTORM.…”

Section: Dstorm Imagingmentioning

confidence: 99%

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Transmembrane MUC18 Targeted Polydopamine Nanoparticles and a Mild Photothermal Effect Synergistically Disrupt Actin Cytoskeleton and Migration of Cancer Cells

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Low doses of zeolitic imidazolate framework-8 nanoparticles alter the actin organization and contractility of vascular smooth muscle cells

Cited by 24 publications

References 78 publications

Cancer-Nano-Interaction: From Cellular Uptake to Mechanobiological Responses

Cancer-Nano-Interaction: From Cellular Uptake to Mechanobiological Responses

Photodynamic and Photothermal Therapy of Hepatocellular Carcinoma

Transmembrane MUC18 Targeted Polydopamine Nanoparticles and a Mild Photothermal Effect Synergistically Disrupt Actin Cytoskeleton and Migration of Cancer Cells

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