Low Doses of Topiramate are Effective in Essential Tremor: A Report of Three Cases

Gatto, Emilia; Roca, Marcela C. Uribe; Raina, Gabriela; Micheli, Federico

doi:10.1097/00002826-200311000-00006

Cited by 31 publications

(12 citation statements)

References 19 publications

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“…9 Initially, complex epilepsy was the only indication for treatment with topiramate. Recently it has been suggested that topiramate may be useful in the treatment of obesity [10][11][12][13][14][15] , eating disorders [16][17][18][19][20] , migraine [21][22][23][24][25][26][27][28][29][30][31] , bipolar disorders [32][33][34][35] , other psychiatric disorders [36][37][38][39][40][41][42] , alcohol dependence [43][44][45][46][47] and other addictive disorders 48 . Also the drug is more frequently used in the management of childhood epilepsy [49][50][51] .…”

Section: Introductionmentioning

confidence: 99%

Retinal function and histopathology in rabbits treated with Topiramate

et al. 2006

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Methods: Six rabbits were treated with a daily oral dose of topiramate orally during a period of eight months. Six rabbits receiving water served as controls. Blood samples were analyzed for determination of topiramate serum levels in order to ensure successful drug exposition.Standardized full-field electroretinograms (ERGs) were performed before treatment and then at 2, 3 and 8 months during the treatment period. After terminating treatment the rabbits were sacrificed and the morphology of the sectioned retina was studied. The retinal dysfunction and the morphological changes indicate that topiramat may damage the retina, similarly to vigabatrin (another anti-epileptic drug).

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Section: Introductionmentioning

confidence: 99%

Retinal function and histopathology in rabbits treated with Topiramate

et al. 2006

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“…In summary, this case study demonstrates an additional opportunity to treat ET in elderly patients with dementia, but prescription should be considered very carefully with frequently performed titration to find out the lowest effective dosage [5], and monitoring of the mental status should be performed regularly under topiramate treatment.…”

Section: Resultsmentioning

confidence: 99%

“…Propanolol and primidone cause side effects, especially in the elderly, and interact often with drugs usually used in older people [4]. Topiramate was referred being effective in treating essential tremor in case studies [5] as well as in double-blind placebo-controlled studies [2]. …”

Section: Introductionmentioning

confidence: 99%

Topiramate Treatment of Essential Tremor in a Patient with Cognitive Deficits

Leblhuber¹,

Steiner²

2010

Case Rep Neurol

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This case report demonstrates a satisfying response to topiramate in a 79-year-old patient with disabling essential tremor in whom propranolol as well as primidone had to be discontinued due to severe side effects. After 28 months of topiramate treatment, a clear decline in Mini Mental State Examination (MMSE) could be observed, stressing the use of care in prescribing topiramate in elderly patients.

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“…15 Topiramate appears to be efficacious at doses lower than those used to treat approved conditions with studies suggesting benefit below 100 mg/day. 15,18 Dose limiting side effects include paresthesias, nausea, and cognitive issues. In epilepsy studies, the incidence of cognitive issues is 40%-50% and, in migraine studies with slower titrations, 20%.…”

Section: Topiramatementioning

confidence: 99%