Emerging Therapies for the Treatment of Essential Tremor

Abstract

This article will review newer therapies for the treatment of essential tremor as well as cover potential therapies still in development. Drug pharmacology, specific dosing for ET and adverse effects will be reviewed. Finally, a rationale approach to treatment of ET will be discussed.

“Old” and emerging Therapies of Human Tremor

“…This knowledge will impact on the development of future therapies. 16,82 Combination of so-called “old” and new therapies are likely to occur in the next decade.…”

“…First line therapy for ET remains based on propranolol or primidone. 16 Primidone is significantly superior to placebo in reducing the magnitude of hand postural tremor. Its efficacy is similar to propranolol.…”

“…15 essential tremor First line therapy for ET remains based on propranolol or primidone. 16 Primidone is significantly superior Dopamine agonists, such as pramipexole and ropinirole, are probably the most effective tremorolytic drugs among all dopaminergic treatments available and should be considered in newly diagnosed PD patients exhibiting tremor in absence of cognitive impairment. 8 Improvement of tremor has also been reported with other dopamine agonists, including pergolide and bromocriptine.…”