Low doses of curcumin protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK

Lee, Hae-In; McGregor, Robin A.; Choi, Myung‐Sook; Seo, Kown-Il; Jung, Un Ju; Yeo, Jiyoung; Kim, Myung-Joo

doi:10.1016/j.lfs.2013.09.014

Cited by 70 publications

(45 citation statements)

References 39 publications

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“…These antioxidant agents include natural antioxidants [e.g., vitamin C, E, coenzyme Q10, alpha-lipoic acid, fish oil containing n-3 fatty acids, betaine, and S-adenosyl-methionine (SAMe)], L-arginine, small-molecule metabolites (e.g., GSH-ethyl ester and NAC), and plants polyphenols (silimarin in milk thistle, curcumin, esculetin, sulforaphane, resveratrol, quercetin, epigallocatechin-3-gallate, caffeic acid phenethyl ester, and many others) (Andringa et al, 2010;Bailey et al, 2006;Cao et al, 2013;Cederbaum, 2010;Choi et al, 2013;Chung et al, 2012;Esfandiari et al, 2007;Ji & Kaplowitz, 2003;Kharbanda et al, 2012;Kim, Nagy, et al, 2014;Kim, Quon, & Kim, 2014;Lee, Mcgregor, et al, 2013;Lee, Yun, Seo, Kim, & Lee, 2014;Lieber, 2002;Marcolin et al, 2012;Nanji et al, 2003;Powell et al, 2010;Rodrigues et al, 2013;Scorletti et al, 2014;Shin et al, 2014;Song, et al, 2008;Surapaneni et al, 2014). These antioxidants, contained in many fruits and vegetables, show beneficial effects on AFLD, NAFLD, and DILI, although some of these antioxidants also exhibit significant protection in other tissues such as heart, muscle, and brain (Pallauf, Giller, Huebbe, & Rimbach, 2013;Rodriguez et al, 2015).…”

Section: Translational Research Opportunitiesmentioning

confidence: 99%

Translational Implications of the Alcohol-Metabolizing Enzymes, Including Cytochrome P450-2E1, in Alcoholic and Nonalcoholic Liver Disease

Song

Akbar

et al. 2015

Advances in Pharmacology

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Section: Translational Research Opportunitiesmentioning

confidence: 99%

Translational Implications of the Alcohol-Metabolizing Enzymes, Including Cytochrome P450-2E1, in Alcoholic and Nonalcoholic Liver Disease

Song

Akbar

et al. 2015

Advances in Pharmacology

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“…Alcoholic liver disease (ALD) develops in approximately 20% of alcoholics [1]. It is primarily caused by the byproducts of alcohol metabolism that promote the development of steatosis, which can lead to steatohepatitis, fibrosis, cirrhosis, and/or hepatocellular carcinoma [3]. ALD is a major health problem in the United States, accounting for 15% of the total healthcare costs, and it is associated with a mortality rate of 20% [4].…”

Section: Introductionmentioning

confidence: 99%

“…It has been demonstrated that oxidative stress is involved in the pathogenesis of ALD, as ROS generation has been observed in alcohol-exposed cultured cells and in alcohol-exposed mouse embryos [11]. It has also been shown that curcumin reduces inflammation by inhibiting NF- κ B in alcohol-exposed rats [3]. …”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effects of Antrodia cinnamomea: The Modulation of Oxidative Stress Signaling in a Mouse Model of Alcohol‐Induced Acute Liver Injury

Liu

Wang

et al. 2017

Oxidative Medicine and Cellular Longevity

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In the present study, the components of A. cinnamomea (AC) mycelia were systematically analyzed. Subsequently, its hepatoprotective effects and the underlying mechanisms were explored using a mouse model of acute alcohol-induced liver injury. AC contained 25 types of fatty acid, 16 types of amino acid, 3 types of nucleotide, and 8 types of mineral. The hepatoprotective effects were observed after 2 weeks of AC treatment at doses of 75 mg/kg, 225 mg/kg, and 675 mg/kg in the mouse model. These effects were indicated by the changes in the levels of aspartate aminotransferase, alanine aminotransferase, several oxidation-related factors, and inflammatory cytokines in serum and/or liver samples. AC reduced the incidence rate of necrosis, inflammatory infiltration, fatty droplets formation, and cell apoptosis in liver detecting via histological and TUNEL assay. In addition, AC reduced the expression of cleaved caspase-3, -8, and -9 and the levels of phosphor-protein kinase B (Akt) and phosphor-nuclear factor-κB (NF-κB) in the liver samples. Collectively, AC-mediated hepatoprotective effects in a mouse model of acute alcohol-induced liver injury are the result of reduction in oxidative stress. This may be associated with Akt/NF-κB signaling. These results provide valuable evidence to support the use of A. cinnamomea as a functional food and/or medicine.

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“…ROS may combine with macromolecules, including DNA and proteins, causing lipid peroxidation and muscle fatigue (33). MDA regulates ATP synthase via the mitochondrial respiratory chain, which is an indirect indicator of membrane damage (34). Enzymatic and non-enzymatic antioxidants exhibit two classic patterns of endogenous protective mechanisms to prevent oxidative stress (35).…”

Section: Tm (G/kg) Tm (G/kg) ----------------------------------------mentioning

confidence: 99%

The anti‑fatigue activities of Tuber melanosporum in a mouse model

Jiang

Chu

et al. 2018

Exp Ther Med

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Abstract. Tuber melanosporum (TM) is an edible fungus that exhibits antioxidant and anti-tumor activity via its unique bioactive metabolites. The present study analyzed the anti-fatigue effects of TM using a BALB/c mouse model. The anti-fatigue properties of TM were evaluated by assessing the endurance of mice by performing forced swimming, rotary rod and running tests. Following 2 weeks TM treatment, hepatic and muscular ATP, and glycogen levels were increased in mice subjected to 30 min swimming, compared with controls. Similarly, levels of serum lactic acid and lactic dehydrogenase were decreased in the same group, compared with the control. Additionally, TM treatment reduced reactive oxygen species and malondialdehyde levels, and increased superoxide dismutase and glutathione peroxidase levels in the muscle, liver and/or serum. The effect of TM on hormone levels was also investigated in the present study, as different efficacies of TM were observed in male and female mice. TM treatment increased serum levels of progesterone, estradiol and testosterone in female and male mice, whereas a decrease in serum luteinizing hormone levels was only observed in females. A decrease in serum follicle-stimulating hormone levels was identified in females, whereas an increase was observed in males. The current study demonstrated that the anti-fatigue effects of TM occur via the regulation of oxidative stress, energy metabolism and hormone levels.

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Low doses of curcumin protect alcohol-induced liver damage by modulation of the alcohol metabolic pathway, CYP2E1 and AMPK

Cited by 70 publications

References 39 publications

Translational Implications of the Alcohol-Metabolizing Enzymes, Including Cytochrome P450-2E1, in Alcoholic and Nonalcoholic Liver Disease

Translational Implications of the Alcohol-Metabolizing Enzymes, Including Cytochrome P450-2E1, in Alcoholic and Nonalcoholic Liver Disease

Hepatoprotective Effects of Antrodia cinnamomea: The Modulation of Oxidative Stress Signaling in a Mouse Model of Alcohol‐Induced Acute Liver Injury

The anti‑fatigue activities of Tuber melanosporum in a mouse model

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