“…81 Local urokinase infusion, on the other hand, has been reported to enhance clot lysis significantly and to aid dramatically in resolving shock secondary to invasive emboli. 82 Some contend that local therapy is more effective than systemic administration owing to the action of alpha-2-macroglobulin inhibitors of urokinase, which reach the system circulation. 82 Whatever its mechanism of action, there is certainly enough evidence to recommend continuation of clinical trials for regional thrombolytic infusion.…”