Low Dose Perioperative Intravenous Tranexamic Acid in Patients Undergoing Total Knee Arthroplasty: A Double-Blind Randomized Placebo Controlled Clinical Trial

Motififard, Mehdi; Tahririan, Mohammad Ali; Saneie, Mehdi; Badiei, Sajad; Nemati, Amin

doi:10.1155/2015/948304

Cited by 9 publications

(6 citation statements)

References 33 publications

(25 reference statements)

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“…Overall, 9,067 patients received TXA while 6,592 were included in the control groups. With regard to the type of surgery, 82 studies [ 21 – 24 , 26 – 28 , 30 , 31 , 34 – 38 , 40 , 45 , 47 , 49 – 51 , 55 – 58 , 60 , 61 , 63 , 65 , 66 , 70 , 72 , 73 , 75 , 76 , 78 – 82 , 84 , 85 , 87 , 88 , 90 , 92 , 93 , 96 , 98 , 99 , 104 – 111 , 113 , 114 , 117 – 119 , 121 , 123 , 124 , 126 – 128 , 130 , 134 – 137 , 140 – 142 , 146 , 147 , 151 , 153 , 154 , 156 ] (5,267 cases and 3,498 controls) were focused on TKA, 41 studies [ 11 , 12 , 25 , 32 , 33 , 42 – 44 , 48 , 52 – 54 , 62 , 64 , 67 – …”

Section: Resultsmentioning

confidence: 99%

Complications of Tranexamic Acid in Orthopedic Lower Limb Surgery: A Meta-Analysis of Randomized Controlled Trials

Reale

Andriolo

Gürsoy

et al. 2021

BioMed Research International

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Objective. Tranexamic acid (TXA) is increasingly used in orthopedic surgery to reduce blood loss; however, there are concerns about the risk of venous thromboembolic (VTE) complications. The aim of this study was to evaluate TXA safety in patients undergoing lower limb orthopedic surgical procedures. Design. A meta-analysis was performed on the PubMed, Web of Science, and Cochrane Library databases in January 2020 using the following string (Tranexamic acid) AND ((knee) OR (hip) OR (ankle) OR (lower limb)) to identify RCTs about TXA use in patients undergoing every kind of lower limb surgical orthopedic procedures, with IV, IA, or oral administration, and compared with a control arm to quantify the VTE complication rates. Results. A total of 140 articles documenting 9,067 patients receiving TXA were identified. Specifically, 82 studies focused on TKA, 41 on THA, and 17 on other surgeries, including anterior cruciate ligament reconstruction, intertrochanteric fractures, and meniscectomies. The intravenous TXA administration protocol was studied in 111 articles, the intra-articular in 45, and the oral one in 7 articles. No differences in terms of thromboembolic complications were detected between the TXA and control groups neither in the overall population (2.4% and 2.8%, respectively) nor in any subgroup based on the surgical procedure and TXA administration route. Conclusions. There is an increasing interest in TXA use, which has been recently broadened from the most common joint replacement procedures to the other types of surgeries. Overall, TXA did not increase the risk of VTE complications, regardless of the administration route, thus supporting the safety of using TXA for lower limb orthopedic surgical procedures.

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Section: Resultsmentioning

confidence: 99%

Complications of Tranexamic Acid in Orthopedic Lower Limb Surgery: A Meta-Analysis of Randomized Controlled Trials

Reale

Andriolo

Gürsoy

et al. 2021

BioMed Research International

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“…Ralley FE et al (7) used a single intra-operative dose of 20 mg/kg while Motififiard M et al (8) used two dose regimen of 500 mg Tranexamic Acid. Hiippala ST et al (9) Evaluate the role of Tranexamic Acid in Joint Replacement Surgeries DOI: 10.9790/0853-1605030308 www.iosrjournals.org 6 | Page used a three dose regimen with 10 mg/kg intra-operative and two post-operative doses, Sabatini L et al (10) used 10 mg/kg bolus with infusion and repeat dose after 3 hours, Maniar RN et al (11) compared three different regimen (intra-operative dose before tourniquet deflation, additional pre-operative dose and additional postoperative dose) and found that minimum two dose regimen is needed for significant reduction in blood loss.…”

Section: Discussion Dose and Timing Of Drug Administrationmentioning

confidence: 99%

Evaluate The Role of Tranexamic Acid In Joint Replacement Surgeries

Yadav¹,

Chauhan²,

Peshin³

2017

IOSR JDMS

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“…The medical records of patients undergoing unilateral TKA at out institution between January 2010 and December 2011 were retrospectively reviewed. Inclusion criteria were: (1) diagnosis of knee osteoarthritis according to the most recent diagnostic criteria of the American Rheumatic Society; (2) unilateral TKA surgery; (3) MP implant or PS prosthesis; and (3) ! 1 year of follow-up.…”

Section: Methodsmentioning

confidence: 99%

Total Knee Arthroplasty Using a Medial Pivot or Posterior Cruciate-Stabilizing Prosthesis in Chinese Patients

Yuan

Zhang

et al. 2019

J Knee Surg

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There is an unmet need for a prosthesis designed according to the anatomical parameters of the Chinese population. This study aims to compare the use of a medial pivot (MP) implant or posterior cruciate ligament (PCL) substitution (posterior-stabilized [PS]) prosthesis for unilateral total knee arthroplasty (TKA) in a Chinese population. The medical records of patients undergoing unilateral TKA with an MP implant (Group A) or a PS prosthesis (Group B) at our institution between January 2010 and December 2011 were retrospectively reviewed. Patients were followed up for 5 years. Preoperatively and at the December 2016 postoperative follow-up, the Hospital for Special Surgery scoring system (HSS knee score) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score were measured to evaluate TKA outcomes. This study included 49 patients in Group A and 51 in Group B. As of December 2016, there were no significant differences in the preoperative/postoperative changes in any category of the HSS knee score or WOMAC score between the groups. There were no postoperative complications in either group during the 5-year follow-up. There were no periprosthetic infections or need for revision surgery. One patient in Group A experienced aching and a small amount of effusion in the articular cavity that was attributed to overexertion. In conclusion, there were no significant differences in midterm outcomes in Chinese patients receiving an MP implant or a PS prosthesis for unilateral TKA. These data suggest that the MP and PCL substitution design are safe and effective for unilateral TKA in China.

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Low Dose Perioperative Intravenous Tranexamic Acid in Patients Undergoing Total Knee Arthroplasty: A Double-Blind Randomized Placebo Controlled Clinical Trial

Cited by 9 publications

References 33 publications

Complications of Tranexamic Acid in Orthopedic Lower Limb Surgery: A Meta-Analysis of Randomized Controlled Trials

Complications of Tranexamic Acid in Orthopedic Lower Limb Surgery: A Meta-Analysis of Randomized Controlled Trials

Evaluate The Role of Tranexamic Acid In Joint Replacement Surgeries

Total Knee Arthroplasty Using a Medial Pivot or Posterior Cruciate-Stabilizing Prosthesis in Chinese Patients

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