Evaluate The Role of Tranexamic Acid In Joint Replacement Surgeries

Yadav, Shreyash; Chauhan, Vijendra; Peshin, Chetan

doi:10.9790/0853-1605030308

Cited by 1 publication

(3 citation statements)

References 17 publications

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“…These are seen when tranexamic acid is administered rapidly 31 , however in our study we administered tranexamic acid slowly before induction of anaesthesia. The results of studies by Yadav et al 23 and Dahuja et al 20 stand in support of our results. In our study long term adverse effects of tranexamic acid (Deep vein thrombosis, pulmonary embolism, cerebrovascular episode) were not studied.…”

Section: Discussionsupporting

confidence: 93%

“…Our results were comparable with the study by Thipparampall et al 6 who showed that the difference between control group (C) (26.7 ± 3.04 %) and bolus group (B) (31.3 ± 4.22%) with respect to postoperative haematocrit on day 1 was statistically significant (p < 0.05). There was significant drop in the haemoglobin postoperatively in group C as compared to group T (p < 0.0001).Studies by Seijas et al, 28 Vijay et al, 11 Dhawale et al, 29 Chang et al 30 and Yadav et al 23 show results in accordance with our result (p<0.05). The difference between group C and T with respect to drop in haematocrit was statistically significant (p < 0.0001).…”

Section: Discussionsupporting

confidence: 91%

“…Thus, it prevents dissolution of the fibrin clots. 23 Benoni et al, 17 Luo et al 24 and Xie et al 25 found result parallel to our study (p= 0.01). We found that mean postoperative haemoglobin levels in group C was significantly less as compared to group T. Thipparampall et al 6 found that the difference between control group (8.8 ± 0.98 g%) and bolus group (10.1 ± 1.61 g%) with respect to postoperative haemoglobin levels at day one (1) was statistically significant.…”

Section: Discussionsupporting

confidence: 88%

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Evaluation of Role of Tranexamic Acid in Reducing Blood Loss and Transfusion Rate in Patients Undergoing Lower Limb Orthopaedic Surgeries

Jejani¹,

Chaudhari²,

Singam³

et al. 2020

jemds

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BACKGROUND Major surgeries like hip arthroplasty, knee arthroplasty etc.; are associated with excessive bleeding. Uncontrolled bleeding can lead to increased morbidity and mortality and may necessitate blood transfusions. This prospective, randomized study was designed to evaluate the efficacy and safety of injection tranexamic acid in reducing blood loss and rate of blood transfusion in lower limb orthopaedic surgeries without tourniquet under subarachnoid block. METHODS After approval from institutional ethical committee, the study was carried out on 80 patients who were divided into two groups of 40 patients each. Patients in group T received a bolus dose of 10 mg/Kg injection tranexamic acid 10 minutes before induction of anaesthesia and patients in group C received 0.9% 10 ml normal saline. Intraoperative and postoperative blood loss were recorded and added together for total blood loss. Postoperative haemoglobin and haematocrit were evaluated 24 hrs. after surgery. The number of patients who received blood transfusion and the number of units of blood transfused postoperatively were recorded. Early adverse reactions of tranexamic acid were recorded and treated. p<0.05 was considered significant. RESULTS Mean intraoperative blood loss in group C (489.75+123.63 ml) was more than group T (450 + 138.66 ml) (p> 0.05). Postoperative blood loss was significantly less in group T (163.67 ± 44.13 ml) as compared to group C (205.43 ± 63.31 ml) (p<0.05). The mean total blood loss was significantly less in group T (613.67 ± 167.40 ml) as compared to group C (695.2 ± 162.44 ml) (p< 0.05). The drop in postoperative haemoglobin and haematocrit was significantly higher in group C as compared to group T (p < 0.0001). Significantly higher number of patients in group C (15) received postoperative blood transfusion as compared to group T (7) (p< 0.05). Acute adverse effects of tranexamic acid and complication of blood transfusion were not seen. CONCLUSIONS Injection tranexamic acid in a bolus dose of 10 mg/Kg is an effective and safe strategy to reduce blood loss and to minimise the rate of blood transfusions in lower limb orthopaedic surgeries without tourniquet under spinal anaesthesia.

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Section: Discussionsupporting

confidence: 93%