Low-dose oxytocin delivered intranasally with Breath Powered device affects social-cognitive behavior: a randomized four-way crossover trial with nasal cavity dimension assessment

Quintana, Daniel; Westlye, Lars T.; Rustan, Øyvind; Tesli, Natalia; Poppy, Claire; Smevik, Hanne; Tesli, Martin; Røine, Marianne; Mahmoud, Ramy; Smerud, Knut; Djupesland, Per G.; Andreassen, Ole A.

doi:10.1038/tp.2015.93

Cited by 86 publications

(103 citation statements)

References 85 publications

(105 reference statements)

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“…For example, the most effective nasal spray dose to use is still not known. In fact, we have found that a smaller dose may be more helpful than a larger dose [6] -bigger may not be better! Scientists are also still discovering exactly how oxytocin given through the nose might travel to the brain.…”

Section: What Else Do We Still Need To Learn About Oxytocin Nasal Spray?mentioning

confidence: 86%

“…The way that oxytocin is sprayed up the nose also influences its effects. The most commonly used nasal spray devices may not be the best method to deliver oxytocin, and new types of sprays that are better for delivering oxytocin to the brain are currently being tested [6]. Overall, it is clear that more work is needed to understand all the factors that influence the response to nasally delivered oxytocin.…”

Section: What Else Do We Still Need To Learn About Oxytocin Nasal Spray?mentioning

confidence: 99%

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Oxytocin: How Does This Neuropeptide Change Our Social Behavior?

Quintana¹,

Alvares²

2016

Front. Young Minds.

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Neuropeptides are small molecules that act as messengers between different brain regions. There are roughly 100 neuropeptides that are important for various functions, including hunger, memory, and learning. Oxytocin is a neuropeptide that plays a crucial role in childbirth and breastfeeding. More recently, oxytocin has been shown to be essential for our social behaviors. When given to people in the form of a nasal spray, oxytocin can change key aspects of social behavior, such as how easily we can recognize emotions in others. People with autism often have difficulties in understanding and using social information, and scientists have been testing oxytocin nasal spray as a potential treatment. But how does oxytocin nasal spray travel from the nose to the brain, and how does it change how we behave socially?Neuropeptides are small molecules that act as messengers between different brain regions. There are roughly 100 neuropeptides that control various functions, including hunger, memory, and learning. Oxytocin is a neuropeptide that plays a crucial role in childbirth and breastfeeding. Oxytocin is produced in the hypothalamus, an almond-sized structure near the base of our brain. After production, oxytocin moves from the hypothalamus to the Neuropeptide A small molecule naturally produced in the body that acts a messenger to trigger responses in our body, such as the feeling of hunger. OxytocinA neuropeptide (see above) that is known to influence how we behave around other people.

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Section: What Else Do We Still Need To Learn About Oxytocin Nasal Spray?mentioning

confidence: 86%

Section: What Else Do We Still Need To Learn About Oxytocin Nasal Spray?mentioning

confidence: 99%

Oxytocin: How Does This Neuropeptide Change Our Social Behavior?

Quintana¹,

Alvares²

2016

Front. Young Minds.

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“…Yes, as I mentioned briefly earlier, we've published a study in healthy volunteers in Phase I studies, where we had an intravenous oxytocin comparison [14,15]. Here we had a placebo and two different doses of oxytocin delivered to the volunteers using our device.…”

Section: How Does Optinose Delivery Technology Hope To Overcome the Dmentioning

confidence: 99%

“…We delivered oxytocin via the intranasal and also the intravenous route as a comparison [14,15]. Despite similar levels in the blood, significant differences in cognitive tests and corresponding brain activation were observed.…”

Section: How Does Optinose Delivery Technology Hope To Overcome the Dmentioning

confidence: 99%

Looking to the Future of Nasal Drug Delivery–an Interview With Per Gisle Djupesland

Djupesland

2018

Ther. Deliv.

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OptiNose patent families/patent applications, and serves as Chief Scientific Officer of OptiNose AS, with primary responsibility for device discovery and early development efforts. These early development efforts include identifying new product opportunities that use bi-directional technology, advancing the design of devices using the bi-directional technology to treat a variety of medical conditions and conducting Phase I and IIa trials with new 'nose-to-brain' applications for the technology.Dr Djupesland is an otolaryngologist (ENT) with a specialization in rhinology and more than 25 years of clinical experience. Among other positions prior to OptiNose, he served as a Clinical Research Fellow at the Hospital for Sick Children and Toronto General in Toronto, Canada, primarily studying the role of nitric oxide in the upper airways. Dr Djupesland has authored more than 60 peer reviewed articles in international medical journals and has lectured at numerous international scientific conferences.He earned medical and doctorate degrees in the field of nasal physiology and aerodynamics from the

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“…38,39 A single administration of intranasal 8IU oxytocinmodulated social cognition, whereas intravenous administration did not, despite comparable peripheral blood concentrations of oxytocin after intranasal and intravenous oxytocin administration. 40 This indicates that nose-to-brain transport, rather than transport across the blood-brain barrier via peripherally circulating oxytocin, influences social cognition. Moreover, neural evidence from the same data set also suggested that intranasal 8IU (but not the other oxytocin treatments) reduced amygdala activation during the presentation of social stimuli.…”

Section: Introductionmentioning

confidence: 99%