Low dose oral administration of monosodium glutamate in male albino rats may be nephroprotective

Egbuonu, Anthony Cemaluk C.; Obidoa, Onyechi; Ezeokonkwo, C. A.; Ezeanyika, LU; Ejikeme, Paul M.

doi:10.4314/br.v7i1.45475

Cited by 53 publications

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“…However, Egbuonu et al (2009) reported an elevation of the serum ALT activity in rats. Determination of serum AST levels in this study showed an immediate elevation of serum AST in the Group D rabbits.…”

Section: Discussionmentioning

confidence: 99%

“…Determination of serum AST levels in this study showed an immediate elevation of serum AST in the Group D rabbits. An elevation in serum liver enzymatic activity may indicate hepatotoxic effects of MSG (Egbuonu et al 2009), whereas a decrease indicates hepato-protection (Ochiogu et al 2014). The observed immediate elevation of serum AST activity may indicate a hepatotoxic effect of MSG at the 1 mg/kg body weight dose in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Apart from the earlier reported "Chinese restaurant syndrome" (Kwok 1968) and other reports of the adverse effects of MSG (such as neurotoxic, neuro-excitatory, psychotic, hepatotoxic, diarrhoeic and reproductive-endocrine dysfunction) on different organs and systems in humans and other animals (Schaumberg et al 1969;Egbuonu et al 2009), there is growing concern about the safety of ingesting MSG (Olney and Prince 1978).…”

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confidence: 99%

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The effects of monosodium l-glutamate administration on the reproduction and serum biochemistry of adult male rabbits

Okoye¹,

Ochiogu²,

Onah³

2016

Vet. Med. - Czech

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ABSTRACT:In this study the effects of monosodium l-glutamate (MSG) administration on the reproductive parameters and serum biochemistry of male rabbits were investigated. Sixteen mature male New Zealand mixed-breed of rabbits (Oryctolagus species) weighing 1.1-1.65 kg were used for this study. They were randomised into four groups of four rabbits each. Group A which served as the untreated control, received only distilled water while Groups B, C and D which were the treated groups, received 0.25 g/kg, 0.5 g/kg and 1 g/kg body weight of MSG from a 40% MSG stock solution. The MSG was administered to the rabbits by oral gavage every forty-eight hours for a period of eight weeks. Serum levels of luteinising hormone (LH), testosterone, total cholesterol and total protein, and activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were evaluated on Days 14, 28 and 56 of MSG administration. Results showed that when compared to the untreated group (Group A), on Day 56 of MSG administration the mean serum levels of both LH and testosterone were significantly (P < 0.05) lower in Group D that received 1 g/kg body weight MSG, while the serum cholesterol levels of Group C rabbits that received 0.5 g/kg body weight MSG was significantly (P < 0.05) lower on Day 28 of MSG administration. The mean serum ALT activity of Groups B and C rabbits were significantly (P < 0.05) lower on Day 56 of MSG administration, while the mean serum AST activity of the Group D rabbits was significantly (P < 0.05) higher on Day 14 of MSG administration. There were no significant (P > 0.05) variations in the mean serum total protein between the groups. Testicular histomorphology revealed that MSG administration did not affect the testes of the rabbits as there was no obvious testicular histopathology. It was concluded that administration of MSG to male rabbits significantly lowered serum LH, testosterone and cholesterol levels and serum ALT activity without affecting testicular histomorphology.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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The effects of monosodium l-glutamate administration on the reproduction and serum biochemistry of adult male rabbits

Okoye¹,

Ochiogu²,

Onah³

2016

Vet. Med. - Czech

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“…This invariably indicated overriding adverse influence of downstream or midstream samples exposure on the rats' liver since ALT is a specific marker for liver damage [31] . In previous studies, increased serum ALT activity indicated liver injury [20,16] . Thus, the lower serum ALT activity in the upstream-exposed rats could be suggestive that upstream sample of WRO did not elicit hepatotoxic effect in the rats.…”

Section: Discussionmentioning

confidence: 99%

“…This was based on the optimized standard method as described [18] . Serum aspartate aminotransferase (AST) activity and alanine aminotransferase (ALT) activity were determined by the method of Reitman and Frankel [19] as earlier described earlier [20,21] . This was based on the principle that oxaloacetate or pyruvate respectively reacts with chromogen (2,4-dinitrophenyhydrazine) in an alkaline medium to form coloured hydrazone that is proportional in concentration (as measured from the colour intensity) to the aspartate aminotransferase or alanine aminoteransferase activity.…”

Section: Determination Of Some Seric Bio-functional Indicators Of LIVmentioning

confidence: 99%

Quality Assessment of Waterside River, Ogbor Hill Aba 4: Effect of Three-Point Samples on Hepatic Histo-Morphology and Some Seric Bio-Functional Indicators of Wistar Rats

Egbuonu¹,

Atasie²,

Onyeabo³

et al. 2018

International Journal of Research in Environmental Science

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Preliminary study on the protective effect of vitamin C on monosodium glutamate-induced hepatotoxicity in rats

et al. 2014

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Monosodium glutamate (MSG) is a food additive with a wide range of biological effects but its high dose and prolonged use can cause a toxic effect on the liver. Therefore, the present study was aimed at investigating the role of vitamin C in MSG-induced hepatotoxicity in rats. MSG was administered to rats (by gavage) at a dose of 6 mg/g body weight for 10 days to induce hepatotoxicity, and vitamin C at a dose of 500 mg/kg body weight was coadministered to evaluate its ameliorating effect by measuring alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities in serum; superoxide dismutase (SOD) and catalase activities in liver fraction; lipid peroxidation; and liver weight. It was found that MSG significantly (P<0.05) induced lipid peroxidation (LPO), increased liver weight, and increased activity of SOD and catalase in the liver of animals. The activity of ALT and AST was also increased in the serum on MSG administration. Vitamin C (500 mg/kg) coadministered with MSG significantly reduced LPO and liver weight and decreased the hepatic activity of catalase, but the activity of SOD was not reduced significantly. Also, a significant reduction in ALT and AST activity was observed. MSG induced oxidative stress and hepatic toxicity in the experimental animals at a dose of 6 mg/g body weight. Vitamin C significantly reduced the oxidative stress and hepatic toxicity induced by MSG, thereby providing a protective effect against the MSGinduced hepatotoxicity. The protective effect is associated with decreased LPO and liver weight and decreased activities of catalase, ALT, and AST.

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Low dose oral administration of monosodium glutamate in male albino rats may be nephroprotective

Cited by 53 publications

References 0 publications

The effects of monosodium l-glutamate administration on the reproduction and serum biochemistry of adult male rabbits

The effects of monosodium l-glutamate administration on the reproduction and serum biochemistry of adult male rabbits

Quality Assessment of Waterside River, Ogbor Hill Aba 4: Effect of Three-Point Samples on Hepatic Histo-Morphology and Some Seric Bio-Functional Indicators of Wistar Rats

Preliminary study on the protective effect of vitamin C on monosodium glutamate-induced hepatotoxicity in rats

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