Low-Dose IL-2 Induces Regulatory T Cell–Mediated Control of Experimental Food Allergy

Bonnet, Benjamin; Vigneron, J.; Levacher, Béatrice; Vazquez, Thomas; Pitoiset, Fabien; Brimaud, Faustine; Churlaud, Guillaume; Klatzmann, David; Bellier, Bertrand

doi:10.4049/jimmunol.1501271

Cited by 44 publications

(38 citation statements)

References 49 publications

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“…IL‐2 is a T‐cell proliferative cytokine whose effects are concentration‐dependent. Low doses of IL‐2 have been associated with the preferential induction of Treg cells and have been successfully used to control experimental FA . We can therefore hypothesize that the positive association between IL‐2 concentrations and FA may stem from incorrect maturation/function of the Treg compartment to the benefit of Th cells in the presence of too high IL‐2 concentrations, thus favoring immune dysregulation leading to health disorder such as FA.…”

Section: Discussionmentioning

confidence: 99%

Immune components of early breastmilk: Association with maternal factors and with reported food allergy in childhood

Berdi

Lauzon-Guillain

Forhan

et al. 2019

Pediatric Allergy Immunology

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Background Breastmilk (BM) may participate in driving gut barrier function and immunity in the neonate. We analyzed immune and growth factor concentrations in early BM and their association with maternal/environmental characteristics and with food allergy (FA) in childhood. Methods One BM sample was collected in maternity from some mothers in the EDEN birth cohort (n = 2002 mother‐child dyads). A random selection was performed among available samples (subcohort, n = 272), for which all deliveries were full‐term, various maternal/environmental characteristics were recorded, and parents answered yearly the question “Has a medical doctor diagnosed a FA in your child?” (26 parent‐reported FA cases). Only samples collected between day 2 and day 6 post‐partum were considered for descriptive analysis (n = 263). Samples for all other FA cases available were added to the subcohort (46 additional cases; “casecohort” design). Fifty cytokines, antibodies, and growth factor concentrations were determined using multiplexed kits and analyzed using robust statistical procedures. Results BM components exhibited wide concentration ranges and global day‐to‐day variation. Different clusters of correlated factors appeared, with components from the main cluster related to maternal diet during pregnancy. Primiparity was positively associated with eleven other components, whereas other factors (eg, maternal atopy and smoking) were related to fewer components. Finally, the casecohort design highlighted a positive association between CXCL10, TNFβ, and IL‐2 concentrations and reported FA in childhood. Conclusion Beyond the unique description of early BM composition, we show that immune information transmitted to the neonate is related to various maternal factors and identified components associated with FA diagnosis in childhood.

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Section: Discussionmentioning

confidence: 99%

Immune components of early breastmilk: Association with maternal factors and with reported food allergy in childhood

Berdi

Lauzon-Guillain

Forhan

et al. 2019

Pediatric Allergy Immunology

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show abstract

“…Low-dose human recombinant IL-2 as survival factor for Tregs was injected in an ovalbumin- or peanut-allergic mouse model [54]. It prevented food allergy symptoms, anaphylactic body temperature drop, decreased serum mast cell protease-1 (MCP-1) and IL-5 in mesenteric lymph nodes and increased ovalbumin-specific IFN-γ production in mesenteric lymph nodes and Peyer's patches.…”

Section: Introductionmentioning

confidence: 99%

Outstanding animal studies in allergy I. From asthma to food allergy and anaphylaxis

Jensen‐Jarolim

Pali‐Schöll

Roth‐Walter

2017

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewAnimal models published within the past 18 months on asthma, food allergy and anaphylaxis, all conditions of rising public health concern, were reviewed.Recent findingsWhile domestic animals spontaneously develop asthma, food allergy and anaphylaxis, in animal models, divergent sensitization and challenge routes, dosages, intervals and antigens are used to induce asthmatic, food allergic or anaphylactic phenotypes. This must be considered in the interpretation of results. Instead of model antigens, gradually relevant allergens such as house dust mite in asthma, and food allergens like peanut, apple and peach in food allergy research were used. Novel engineered mouse models such as a mouse with a T-cell receptor for house dust mite allergen Der p 1, or with transgenic human hFcγR genes, facilitated the investigation of single molecules of interest. Whole-body plethysmography has become a state-of-the-art in-vivo readout in asthma research. In food allergy and anaphylaxis research, novel techniques were developed allowing real-time monitoring of in-vivo effects following allergen challenge. Networks to share tissues were established as an effort to reduce animal experiments in allergy which cannot be replaced by in-vitro measures.SummaryNatural and artificial animal models were used to explore the pathophysiology of asthma, food allergy and anaphylaxis and to improve prophylactic and therapeutic measures. Especially the novel mouse models mimicking molecular aspects of the complex immune network in asthma, food allergy and anaphylaxis will facilitate proof-of-concept studies under controlled conditions.

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“…Great efforts are being made to develop novel strategies in animal models exploring combination of mucosal routes [54], bioadhesive carrier systems [34,55], novel immunomodulatory and/or tolerogenic adjuvants [9,10,55,56], immunological drugs to expand Tregs [12] and nanoparticles [56] to prevent or revert food allergy. These finding will undoubtedly provide new parameters to analyze the induction of novel regulatory cell subsets, and cellular and molecular biomarkers for regulatory cell activation, with a direct impact in the design of safer and more effective treatments.…”

Section: Resultsmentioning

confidence: 99%

“…Understanding this complex geneenvironment interaction will allow us to develop novel generation of treatments that could modify aberrant immune activation and chronic diseases. Based on theses premises the use of Th1 proinflammatory [9,10] or immunosuppressant components [11,12] may compensate the deprived immune stimulation and promotion of counter-regulatory circuits that control the Th2-mediated immunity that governs allergic diseases. However, it is currently suspected that not only can microorganism exposure influence the development of the complex immunoregulatory circuits at mucosal sites, but diet and microbiota-derived metabolites are also implicated.…”

Section: Mucosal Vaccines Based On the Hygiene Hypothesis Premisesmentioning

confidence: 99%

Allergen-Specific Immunotherapy for Food Allergy: Latest Advances in Vaccines

Docena¹

2016

IJVV

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Low-Dose IL-2 Induces Regulatory T Cell–Mediated Control of Experimental Food Allergy

Abstract: International audienc

Cited by 44 publications

References 49 publications

Immune components of early breastmilk: Association with maternal factors and with reported food allergy in childhood

Immune components of early breastmilk: Association with maternal factors and with reported food allergy in childhood

Outstanding animal studies in allergy I. From asthma to food allergy and anaphylaxis

Allergen-Specific Immunotherapy for Food Allergy: Latest Advances in Vaccines

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