Low-dose blue light irradiation enhances the antimicrobial activities of curcumin against Propionibacterium acnes

Yang, Ming-Yeh; Chang, Kai‐Chih; Chen, Liang-Yü; Hu, Anren

doi:10.1016/j.jphotobiol.2018.09.021

Cited by 39 publications

(22 citation statements)

References 48 publications

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“…Membrane proteins have been suggested to be the likely preferred targets within antibacterial PDT . Previous studies about the antibacterial activity of curcumin on several bacteria other than A. baumannii also suggested that the bactericidal effect of curcumin is associated with the damage of the integrity and functions of the bacterial membrane . Our study on the protein level is consistent with these results (Figure and Table S1, supporting information).…”

Section: Discussionsupporting

confidence: 91%

“…Based on the information from a detailed investigation of curcumin given in a previous paper, we tested the action of curcumin at concentrations of 25, 50, 100 and 200 μM, assisted with blue light irradiation at 3.0 mW/cm 2 (equivalent to a radiant exposure of 5.4 J/cm 2 ) on imipenem‐resistant A. baumannii .…”

Section: Resultsmentioning

confidence: 99%

“…All solutions were prepared using analytical grade reagents and Milli‐Q water from a Milli‐Q system (Millipore, Bedford, MA, USA). The photoreactive system was set up according to a previous study …”

Section: Methodsmentioning

confidence: 99%

“…Tonnesen et al observed genotoxicity of curcumin on irradiation with visible light for Salmonella typhimurium and Escherichia coli. In our previous study, we showed that when curcumin was combined with visible blue light, it could eradicate the skin‐disease‐causing microbe Propionibacterium acnes by a series of cytotoxic actions . There is also a report showing the application of curcumin in antibacterial PDT against the dental‐caries‐related microbe Streptococcus mutans .…”

Section: Introductionmentioning

confidence: 99%

“…16 In our previous study, we showed that when curcumin was combined with visible blue light, it could eradicate the skin-disease-causing microbe Propionibacterium acnes by a series of cytotoxic actions. 17 There is also a report showing the application of curcumin in antibacterial PDT against the dental-caries-related microbe Streptococcus mutans. 18 Despite these useful discoveries, the detailed mechanisms and which proteins are influenced to achieve the bactericidal effect of curcumin are still unclear.…”

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confidence: 99%

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Identification of carbonylated proteins in a bactericidal process induced by curcumin with blue light irradiation on imipenem‐resistant Acinetobacter baumannii

Chang

Cheng

Lai

et al. 2019

Rapid Comm Mass Spectrometry

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Rationale Antimicrobial photodynamic treatment is potentially an alternative to antibiotics and is also effective against viruses, fungi and some cancers. Our previous studies have shown that blue light combined with curcumin, a chemical from the turmeric plant, exerted effective antimicrobial activity via photodynamic treatment. The study reported in this paper investigates which target proteins are affected after the treatment. Methods We treated imipenem‐resistant Acinetobacter baumannii with blue light and curcumin and used protein carbonylation as a marker for oxidative damage. After treatment, the bacterial proteins were extracted and the protein carbonyls marked using dinitrophenylhydrazide. After enzyme digestion, we used liquid chromatography/nano‐electrospray ionization (LC/nano‐ESI) ion trap mass spectrometry to identify bacterial peptides from a customized database. The functional enrichment analyses of the identified proteins were performed using gene ontology annotation and the STRING protein–protein interaction network. Results The application of curcumin with blue light showed good antibacterial activity against imipenem‐resistant A. baumannii. Using a shotgun proteomics approach, the carbonylated proteins in A. baumannii caused by the photolytic curcumin were identified. The results showed that the proteins related to membrane structures, translation and response to oxidative stress were preferentially modified. Conclusions The photolytic curcumin treatment could be a potential alternative to antibiotics for bacterial infection. In this study, the shotgun proteomics strategy allows us to explore the possible bactericidal mechanisms under this oxidative stress. The result provides a reference for future studies on the enhancement of the action of photolytic curcumin.

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Section: Discussionsupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Identification of carbonylated proteins in a bactericidal process induced by curcumin with blue light irradiation on imipenem‐resistant Acinetobacter baumannii

Chang

Cheng

Lai

et al. 2019

Rapid Comm Mass Spectrometry

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Biological properties of metal complexes of curcumin

et al. 2019

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Curcumin, a naturally occurring phenolic compound isolated from Curcuma longa, has different pharmacological effects, including antiinflammatory, antimicrobial, antioxidant, and anticancer properties. However, curcumin has been found to have a limited bioavailability because of its hydrophobic nature, low-intestinal absorption, and rapid metabolism. Therefore, there is a need for enhancing the bioavailability and its solubility in water in order to increase the pharmacological effects of this bioactive compound. One strategy is curcumin complexation with transition metals to circumvent the abovementioned problems. Curcumin can undergo chelation with various metal ions to form metallo-complexes of curcumin, which may show greater effects as compared with curcumin alone. Promising results with metal curcumin complexes have been observed with regard to antioxidant, anticancer, and antimicrobial activity, as well as in treatment of Alzheimer's disease. The present review provides a concise summary of the characterization and biological properties of curcumin-metal complexes. © 2019 BioFactors, 45(3):304-317, 2019

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Topical Botanicals in Acne and Rosacea

Hooten¹,

Schwartzberg

2021

Integrative Dermatology

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Low-dose blue light irradiation enhances the antimicrobial activities of curcumin against Propionibacterium acnes

Cited by 39 publications

References 48 publications

Identification of carbonylated proteins in a bactericidal process induced by curcumin with blue light irradiation on imipenem‐resistant Acinetobacter baumannii

Identification of carbonylated proteins in a bactericidal process induced by curcumin with blue light irradiation on imipenem‐resistant Acinetobacter baumannii

Biological properties of metal complexes of curcumin

Topical Botanicals in Acne and Rosacea

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