Low-Dosage¹³¹I Therapy of Thyrotoxicosis (Diffuse Goiters)

Radioiodine (131I) Therapy of Graves' Disease: Use of the New High Resolutional Ultrasonic Scanner for the Determination of the Accurate Weight of the Thyroid Gland.

“…The cumulative incidence of late hypothyroidism in our patients cannot be estimated at this stage, but will probably rise to the same level as those in the previous reports since the annual incidence of hypothyroidism did not different among alternative protocols (Hagen et al, 1967;Smith & Wilson 1967;Glennon et al, 1972;Cevallos et al, 1974). However, in the case of patients with allergic reactions to antithyroid drugs, as in our report, a definite effect within a short period is necessary even at the cost of a high incidence of late hypothyroidism.…”

“…The results in the previous studies have varied from 31 to 79% (Werner et al, 1948 ;Cassidy waltes 1956;Franco & Quina 1956;BlomSmith & Wilson 1967;Rapoport et al, 1973;Cevallos et al, 1974;Reudebush et al, 1977;Sridama et al, 1984). In the analysis of various factors which may be related to the effect of radioiodine therapy in this study, a significant difference was observed in the gland size in hyperthyroid and euthyroid groups, and the incidence of euthyroidism was as high as 80% in patients with smaller glands but was extremely low in those with larger glands, indicating that a larger thyroid gland requires a larger radioiodine dose per gram of tissue than a smaller gland.…”

A mathematical model of optimized radioiodine-131 therapy of Graves' hyperthyroidism

“…In an effort to reduce this incidence of late hypothyroidism, Hagen and colleagues reduced the administered quantity of RaI to 3 MBq (80 μCi) per gram of estimated gland weight [2] resulting in a substantial fall in the incidence of hypothyroidism. However, most of their patients had to be maintained on oral potassium iodide for several months after therapy, in order to ameliorate the thyrotoxicosis that persisted while the radioiodine had its effect[3,4]. Failure of this low dose therapy was such that about 25% of patients required a second treatment and 5% required a third.…”

Efeito do propiltiouracil sobre a eficácia da dose terapêutica de iodo radioativo (I-131) no hipertiroidismo por doença de graves

“…O iodo radioativo como tratamento definitivo para doença de Graves ainda não tem se submetido a critérios uniformes em diferentes países (3,4,14). Em relação à dose calculada, as discussões envolvem uso de doses fixas (21)(22)(23)(24)26) ou cálculos da dose levando-se em consideração fatores de gravidade do hipertiroidismo. Em nossa análise, a dose manteve-se como fator preponderante para a cura, além de ter sido o fator mais significativo na análise multivariada (p= 0,008).…”