Low-dimensional materials facilitate the conjugation between fluorogenic boronic acids and saccharides

Guo, Shi; Chen, Jie; Cai, Bi Ying; Chen, Wen Wen; Li, Yu Fei; Sun, Xiaolong; Chen, Guo Rong; He, Xiao; James, Tony D.

doi:10.1039/c6qm00158k

Cited by 7 publications

(3 citation statements)

References 35 publications

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“… 24 For CNTs, a typical D band at ∼1350 cm –1 and a distinct G peak at 1590 cm –1 were observed with a D/G ratio of 0.04. 25 After assembly with TI26 , an increased D/G ratio of 0.19 was observed, suggesting a change in the defect level of CTNs upon peptide coating. From the Raman spectrum, GO exhibited characteristic D and G peaks at ∼1350 and ∼1585 cm –1 , respectively, with a D/G ratio of 0.96.…”

Section: Results and Discussionmentioning

confidence: 97%

“…For example, while minimal signals were detected for TI26 alone, the presence of AuNPs significantly enhanced the Raman peak assigned to the CO stretching (1660 cm –1 ), in-phase C–H/N–H stretching/bending (1537 cm –1 ), and out-of-phase C–H/N–H stretching/bending (1260 cm –1 ) of the peptide . For CNTs, a typical D band at ∼1350 cm –1 and a distinct G peak at 1590 cm –1 were observed with a D/G ratio of 0.04 . After assembly with TI26 , an increased D/G ratio of 0.19 was observed, suggesting a change in the defect level of CTNs upon peptide coating.…”

Section: Results and Discussionmentioning

confidence: 99%

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Fluorogenic Peptide Sensor Array Derived from Angiotensin-Converting Enzyme 2 Classifies Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern

Dou,

Tong,

Xing

et al. 2024

J. Am. Chem. Soc.

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The devastating COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made society acutely aware of the urgency in developing effective techniques to timely monitor the outbreak of previously unknown viral species as well as their mutants, which could be even more lethal and/or contagious. Here, we report a fluorogenic sensor array consisting of peptides truncated from the binding domain of human angiotensin-converting enzyme 2 (hACE2) for SARS-CoV-2. A set of five fluorescently tagged peptides were used to construct the senor array in the presence of different lowdimensional quenching materials. When orthogonally incubated with the wild-type SARS-CoV-2 and its variants of concern (VOCs), the fluorescence of each peptide probe was specifically recovered, and the different recovery rates provide a "fingerprint" characteristic of each viral strain. This, in turn, allows them to be differentiated from each other using principal component analysis. Interestingly, the classification result from our sensor array agrees well with the evolutionary relationship similarity of the VOCs. This study offers insight into the development of effective sensing tools for highly contagious viruses and their mutants based on rationally truncating peptide ligands from human receptors.

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Section: Results and Discussionmentioning

confidence: 97%

Section: Results and Discussionmentioning

confidence: 99%

Fluorogenic Peptide Sensor Array Derived from Angiotensin-Converting Enzyme 2 Classifies Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern

Dou,

Tong,

Xing

et al. 2024

J. Am. Chem. Soc.

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“…This research provides insights into the use of 2D materials for enabling imaging and spatiotemporal tracking of cell fate by peptide probes. Our ongoing research will focus on the use of other 2D materials [25][26][27][28][29][30] for peptide-based cytoskeleton imaging. ) and VAR/GO (4 mM/81 mg mL À1 ) for HeLa cells stably expressing EGFP-a tubulin.…”

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confidence: 99%

Graphene oxide-enhanced cytoskeleton imaging and mitosis tracking

Jiao

et al. 2017

Chem. Commun.

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Design, Synthesis, and Surface Modification of Materials Based on Transition‐Metal Dichalcogenides for Biomedical Applications

et al. 2017

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With the rapid development of nanotechnology, the emerging transition‐metal dichalcogenides (TMDCs) have become one of the most promising inorganic nanomaterials for medical applications due to their distinctive structures and properties. TMDCs with different sizes and morphologies exhibit unique structural advantages, as well as versatile properties. However, concerning their practicability for biomedical applications, routes toward their synthesis and chemical/physical functionalization for biosystem applications must be identified. Herein, recent advances in the design, synthesis, and surface modification of TMDC‐based nanomaterials specific for biomedical applications are reviewed. First, the basic consideration regarding how to fabricate biocompatible TMDCs efficiently for biomedical use is discussed. Solution‐based synthesis methods for 2D TMDCs, as well as TMDC‐based nanocomposites are then summarized. In addition, general strategies applied for surface functionalization of TMDCs are also discussed. Finally, current challenges and future perspectives for these promising materials in biosystem applications are outlined.

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Low-dimensional materials facilitate the conjugation between fluorogenic boronic acids and saccharides

Abstract: We show that low-dimensional materials enhance the conjugation between fluorogenic phenylboronic acids and saccharides.

Cited by 7 publications

References 35 publications

Fluorogenic Peptide Sensor Array Derived from Angiotensin-Converting Enzyme 2 Classifies Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern

Fluorogenic Peptide Sensor Array Derived from Angiotensin-Converting Enzyme 2 Classifies Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern

Graphene oxide-enhanced cytoskeleton imaging and mitosis tracking

Design, Synthesis, and Surface Modification of Materials Based on Transition‐Metal Dichalcogenides for Biomedical Applications

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