Low-Density Lipoprotein Cholesterol Determines Oxidative Stress and Endothelial Dysfunction in Saphenous Veins From Patients With Coronary Artery Disease

Al-Benna, Sammy; Hamilton, Carlene A.; McClure, John; Rogers, Paul N.; Berg, G; Ford, Ian; Delles, Christian; Dominiczak, Anna F.

doi:10.1161/01.atv.0000193626.22269.45

Cited by 50 publications

(57 citation statements)

References 34 publications

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“…The studies so far performed using these methods show that NO plays a central role in the regulation of venous endothelial function, similarly to what it does for arterial endothelial function (33,34). Interestingly, what emerges from these studies is that conditions associated with arterial endothelial dysfunction, like hypertension, smoking, diabetes, coronary artery disease, heart failure and renal failure, are also characterised by a dysfunction of venous endothelium (30,31,(35)(36)(37)(38)(39)(40)(41)(42) …”

Section: Endothelial Dysfunction and Thrombosismentioning

confidence: 92%

Endothelium, venous thromboembolism and ischaemic cardiovascular events

Gresele

Momi

Migliacci³

2010

Thromb Haemost

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SummaryThe association between venous thromboembolism and arterial thrombosis has emerged as consistent clinical observation in the last few years. While several experimental, epidemiological and pharmacologic studies support this association, the initial pathophysiological mechanism linking these two clinical conditions remains to be established. This review discusses the pathophysiological bases and a number of ex- perimental and clinical observations suggesting that the common link between venous thromboembolism and arterial thrombosis is represented by a dysfunctional endothelium.

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Section: Endothelial Dysfunction and Thrombosismentioning

confidence: 92%

Endothelium, venous thromboembolism and ischaemic cardiovascular events

Gresele

Momi

Migliacci³

2010

Thromb Haemost

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“…Superoxide and hydrogen peroxide stimulate mitogen activated protein kinases, specifically, serine threonine kinase/protein kinase B (Akt/PKB), leading to hypertrophy and increased survival of vascular smooth muscle cells [22] and trigger matrix metalloproteinases (MMP), the effects of which are discussed below [23]. Vascular superoxide production has been shown to correlate with aortic compliance [24], augmentation index [13] and endothelial reactivity [25,26]. Vascular NADPH oxidase activity has also been shown to negatively impact vasomotor response to endothelium-dependent agonists [26].…”

Section: Potential Mechanisms Of Inflammation-induced Arterial Stiffementioning

confidence: 99%

“Inflammation and arterial stiffness in humans”

et al. 2014

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“…One of the first steps in atheroclerosis is the penetration of the arterial wall by chemically altered LDL particles (small, dense and/or oxidized). Once they have reached the arterial wall, these lipoproteins stimulate the recruitment of several leukocytes such as macrophages and Th2 lymphocytes [54, 55]. The binding and influx of such inflammatory cells is also dependent upon monocyte recruitment mediators such as P-selectin, E-selectin, vascular cell adhesion molecule-1 and intracellular cell adhesion molecule-1, of which the expression is made possible by circulating cytokines such as tumor necrosis factor-α (TNF-α), CRP and interleukin (IL)-1β [56, 57].…”

Section: What Are the Clinical Manifestations Of The Metabolic Syndrome?mentioning

confidence: 99%

The Quest for the Optimal Assessment of Global Cardiovascular Risk: Are Traditional Risk Factors and Metabolic Syndrome Partners in Crime?

Arsenault¹,

Després

2008

Cardiology

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Global risk calculators such as the Framingham risk score generally take into account traditional risk factors such as age, sex, blood pressure, smoking status, total cholesterol and high-density lipoprotein cholesterol levels, and the presence of diabetes which are recommended to be used in clinical practice to estimate patients’ cardiovascular disease (CVD) risk. Over the last decades, the prevalence of obesity has dramatically increased all over the world. The deleterious form of obesity, visceral obesity, is the most prevalent form of the so-called metabolic syndrome, a constellation of risk factors associated with perturbations of the lipoprotein-lipid profile and of the plasma glucose-insulin homeostasis also likely to be associated with increased blood pressure and a proinflammatory and prothrombotic state. To this date, metabolic syndrome is still in need of a place in global CVD risk prediction. As the metabolic syndrome is not likely to replace currently used global risk scoring algorithms, both traditional risk factors and emerging metabolic markers associated with the metabolic syndrome should be incorporated in future risk scoring systems to be developed in order to adapt CVD risk prediction tools to the epidemic of obesity which has direct consequences on the daily life of health professionals.

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Low-Density Lipoprotein Cholesterol Determines Oxidative Stress and Endothelial Dysfunction in Saphenous Veins From Patients With Coronary Artery Disease

Cited by 50 publications

References 34 publications

Endothelium, venous thromboembolism and ischaemic cardiovascular events

Endothelium, venous thromboembolism and ischaemic cardiovascular events

“Inflammation and arterial stiffness in humans”

The Quest for the Optimal Assessment of Global Cardiovascular Risk: Are Traditional Risk Factors and Metabolic Syndrome Partners in Crime?

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