Low CSF leptin in female suicide attempters with major depression

Westling, Sofie; Åhrén, Bo; Träskman‐Bendz, Lil; Westrin, Åsa

doi:10.1016/j.jad.2003.07.002

Cited by 76 publications

(51 citation statements)

References 42 publications

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“…Clinical data on the possible association of leptin levels with depression are very limited and divergent (30)(31)(32)(33). Two studies reported patients with major depression to have low leptin levels in plasma or cerebrospinal fluid (30,33).…”

Section: Discussionmentioning

confidence: 99%

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Leptin: A potential novel antidepressant

Kim

Frazer

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

386

329

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Leptin, a hormone secreted from adipose tissue, was originally discovered to regulate body weight. The localization of the leptin receptor in limbic structures suggests a potential role for leptin in emotional processes. Here, we show that rats exposed to chronic unpredictable stress and chronic social defeat exhibit low leptin levels in plasma. Systemic leptin treatment reversed the hedoniclike deficit induced by chronic unpredictable stress and improved behavioral despair dose-dependently in the forced swim test (FST), a model widely used for screening potential antidepressant efficacy. The behavioral effects of leptin in the FST were accompanied by increased neuronal activation in limbic structures, particularly in the hippocampus. Intrahippocampal infusion of leptin produced a similar antidepressant-like effect in the FST as its systemic administration. By contrast, infusion of leptin into the hypothalamus decreased body weight but had no effect on FST behavior. These findings suggest that: (i) impaired leptin production and secretion may contribute to chronic stress-induced depression-like phenotypes, (ii) the hippocampus is a brain site mediating leptin's antidepressant-like activity, and (iii) elevating leptin signaling in brain may represent a novel approach for the treatment of depressive disorders.depression ͉ hippocampus ͉ stress ͉ forced swim test ͉ social defeat

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Section: Discussionmentioning

confidence: 99%

“…Two studies reported patients with major depression to have low leptin levels in plasma or cerebrospinal fluid (30,33). However, another clinical study reported that plasma leptin levels did not differ between depressed patients and healthy controls (31).…”

Section: Discussionmentioning

confidence: 99%

Leptin: A potential novel antidepressant

Kim

Frazer

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

386

329

View full text Add to dashboard Cite

show abstract

“…A few studies reported that depression is associated with low leptin levels independent of body mass [45,50] . Furthermore, one study revealed that female suicide attempters with MDD had lower cerebrospinal fluid leptin than in the group with other disorders, even though both groups had similar body mass index (BMI) [51] . Patients with MDD, Obsessive Compulsive Disorder (OCD) and comorbid depression were examined in various studies.…”

Section: Leptin's Role In Mood Regulationmentioning

confidence: 99%

“…Westling et al [51] Low CSF leptin in MDD women Atmaca et al [52] Low in OCD + D Esel et al [57] High in women but not in men Gecici et al [54] High in patients with atypical depressive disorder but not with non-atypical Jow et al [50] Low Emul et al [53] No difference Pasco et al [47] High in females non-smokers Jimenez et al [46] High in patients with post-stroke depression Hafner et al [56] High in men with social isolation and depressed Lawson et al [45] Low Hafner et al [55] High in normal-weight women During antidepressant therapy Himmerich et al [42] High after successful treatment CSF: Cerebrospinal fluid; MDD: Major depressive disorder; OCD + D: Obsessive compulsive disorder + depression.…”

Section: Ref Findingsmentioning

confidence: 99%

Mood disorders: A potential link between ghrelin and leptin on human body?

Zarouna

Wozniak

2015

WJEM

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Leptin and ghrelin are two hormones associated with multiple physiological functions, especially energy balance. Leptin is an adipocyte-secreted hormone discovered in 1950 and ghrelin which was found in 1999, is a peptide hormone produced and secreted in the stomach. A number of previous studies showed that these hormones could be associated with different types of mood disorders. The results of previous studies, nevertheless, are confounded by diverse sample selection and different methodologies. A search for related articles in the PubMed database was attempted. The search covered studies, reports, reviews and editorials published in the last ten years. Older references served as auxiliary sources for comparison purposes. However, due to the different results of the studies, there is a need for more investigation in order to establish the exact biochemical mechanisms that are responsible for these diseases and ghrelin's and leptin's effects on mood. Core tip: Mood disorders are affecting a major amount of the world population. Considering the multiple factors that are contributing in the development of mood disorders, this review emphasizes on the role of leptin and ghrelin hormones. These two hormones have a key role in energy balance but they also have an effect on other physiological functions too, therefore we emphasize on the recent findings which raise a potential link between the hormones and the disorders of mood.

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“…With larger sample sizes, two research groups demonstrated that plasma leptin levels were decreased in patients with major depression independent of body mass status [21,22]. Also, lower levels of leptin in cerebrospinal fluid were found in suicide attempters with depression than those without depression [23,24]. Moreover, decreased levels of leptin in plasma were observed in patients with bipolar disorder [25] and obsessive-compulsive disorder with comorbid major depression [26].…”

Section: Human Studiesmentioning

confidence: 99%

The leptin hypothesis of depression: a potential link between mood disorders and obesity?

Lü

2007

Current Opinion in Pharmacology

250

198

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SummaryThe adipose-derived hormone leptin is well known for its function in the control of energy homeostasis. Recent studies suggest a novel role for this adipokine in the regulation of mood and emotion. Low levels of leptin have been found to be associated with depressive behaviors in rodents and humans. Pharmacological studies indicate that leptin has antidepressant-like efficacy. Both leptin insufficiency and leptin resistance may contribute to alterations of affective status. Identifying the key brain regions that mediate leptin's antidepressant activity and dissecting its intracellular signal transduction pathways may provide new insights into the pathogenesis of depression and facilitate the development of novel therapeutic strategies for the treatment of this illness.

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Low CSF leptin in female suicide attempters with major depression

Cited by 76 publications

References 42 publications

Leptin: A potential novel antidepressant

Leptin: A potential novel antidepressant

Mood disorders: A potential link between ghrelin and leptin on human body?

The leptin hypothesis of depression: a potential link between mood disorders and obesity?

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