Low-Cost Microfluidic Sensors with Smart Hydrogel Patterned Arrays Using Electronic Resistive Channel Sensing for Readout

Leu, Hsuan-Yu; Farhoudi, Navid; Reiche, Christopher F.; Körner, Julia; Mohanty, Swomitra K.; Solzbacher, Florian; Magda, Jules J.

doi:10.3390/gels4040084

Cited by 18 publications

(13 citation statements)

References 12 publications

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“…In recent studies, scientists have described methods for the fabrication of economical, yet promptly responsive, hydrogels by creating microscopic, smart hydrogel pillar-like edifices with enhanced surface area to volume ratios built within microfluidic channels. When these pillars encounter the target, molecules present in the solutions, they shrink and swell, leading to an alteration in resistance, which can be analyzed by the use of a potentiostat [141]. However, the inconsistent swelling properties of smart hydrogels remains as a challenge for their use in biosensing applications.…”

Section: Smart Hydrogels: Newer Advancesmentioning

confidence: 99%

Smart Hydrogels in Tissue Engineering and Regenerative Medicine

et al. 2019

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The field of regenerative medicine has tremendous potential for improved treatment outcomes and has been stimulated by advances made in bioengineering over the last few decades. The strategies of engineering tissues and assembling functional constructs that are capable of restoring, retaining, and revitalizing lost tissues and organs have impacted the whole spectrum of medicine and health care. Techniques to combine biomimetic materials, cells, and bioactive molecules play a decisive role in promoting the regeneration of damaged tissues or as therapeutic systems. Hydrogels have been used as one of the most common tissue engineering scaffolds over the past two decades due to their ability to maintain a distinct 3D structure, to provide mechanical support for the cells in the engineered tissues, and to simulate the native extracellular matrix. The high water content of hydrogels can provide an ideal environment for cell survival, and structure which mimics the native tissues. Hydrogel systems have been serving as a supportive matrix for cell immobilization and growth factor delivery. This review outlines a brief description of the properties, structure, synthesis and fabrication methods, applications, and future perspectives of smart hydrogels in tissue engineering.

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Section: Smart Hydrogels: Newer Advancesmentioning

confidence: 99%

Smart Hydrogels in Tissue Engineering and Regenerative Medicine

et al. 2019

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“…Hydrogels, intended for bioprinting, are important to downstream applications such as injectable drug delivery. Microfluidics are also rapidly emerging to develop innovative strategies in questions on stimuli-responsive, self-healing, composites, as well as other applications [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ]. The area of biomaterials also include active studies to optimize and customize existing thermoplastic polymers like polycaprolactone [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

A 3D Bioprinted Material That Recapitulates the Perivascular Bone Marrow Structure for Sustained Hematopoietic and Cancer Models

et al. 2021

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Translational medicine requires facile experimental systems to replicate the dynamic biological systems of diseases. Drug approval continues to lag, partly due to incongruencies in the research pipeline that traditionally involve 2D models, which could be improved with 3D models. The bone marrow (BM) poses challenges to harvest as an intact organ, making it difficult to study disease processes such as breast cancer (BC) survival in BM, and to effective evaluation of drug response in BM. Furthermore, it is a challenge to develop 3D BM structures due to its weak physical properties, and complex hierarchical structure and cellular landscape. To address this, we leveraged 3D bioprinting to create a BM structure with varied methylcellulose (M): alginate (A) ratios. We selected hydrogels containing 4% (w/v) M and 2% (w/v) A, which recapitulates rheological and ultrastructural features of the BM while maintaining stability in culture. This hydrogel sustained the culture of two key primary BM microenvironmental cells found at the perivascular region, mesenchymal stem cells and endothelial cells. More importantly, the scaffold showed evidence of cell autonomous dedifferentiation of BC cells to cancer stem cell properties. This scaffold could be the platform to create BM models for various diseases and also for drug screening.

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“…Once the pillars face their target, molecules existing in the liquids, exhibit swelling-deswelling responsive reactions. Consequently, change in resistance can be investigated using a potentiostat [ 339 ]. These smart hydrogels have afforded inexpensive, yet prompt responsive models for biosensing applications.…”

Section: Smart/stimuli-responsive Hydrogels Employed For Different Biomedical Applicationsmentioning

confidence: 99%

Smart/stimuli-responsive hydrogels: Cutting-edge platforms for tissue engineering and other biomedical applications

El-Husseiny

Mady

Hamabe

et al. 2022

Materials Today Bio

193

139

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Recently, biomedicine and tissue regeneration have emerged as great advances that impacted the spectrum of healthcare. This left the door open for further improvement of their applications to revitalize the impaired tissues. Hence, restoring their functions. The implementation of therapeutic protocols that merge biomimetic scaffolds, bioactive molecules, and cells plays a pivotal role in this track. Smart/stimuli-responsive hydrogels are remarkable three-dimensional (3D) bioscaffolds intended for tissue engineering and other biomedical purposes. They can simulate the physicochemical, mechanical, and biological characters of the innate tissues. Also, they provide the aqueous conditions for cell growth, support 3D conformation, provide mechanical stability for the cells, and serve as potent delivery matrices for bioactive molecules. Many natural and artificial polymers were broadly utilized to design these intelligent platforms with novel advanced characteristics and tailored functionalities that fit such applications. In the present review, we highlighted the different types of smart/stimuli-responsive hydrogels with emphasis on their synthesis scheme. Besides, the mechanisms of their responsiveness to different stimuli were elaborated. Their potential for tissue engineering applications was discussed. Furthermore, their exploitation in other biomedical applications as targeted drug delivery, smart biosensors, actuators, 3D and 4D printing, and 3D cell culture were outlined. In addition, we threw light on smart self-healing hydrogels and their applications in biomedicine. Eventually, we presented their future perceptions in biomedical and tissue regeneration applications. Conclusively, current progress in the design of smart/stimuli-responsive hydrogels enhances their prospective to function as intelligent, and sophisticated systems in different biomedical applications.

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Low-Cost Microfluidic Sensors with Smart Hydrogel Patterned Arrays Using Electronic Resistive Channel Sensing for Readout

Cited by 18 publications

References 12 publications

Smart Hydrogels in Tissue Engineering and Regenerative Medicine

Smart Hydrogels in Tissue Engineering and Regenerative Medicine

A 3D Bioprinted Material That Recapitulates the Perivascular Bone Marrow Structure for Sustained Hematopoietic and Cancer Models

Smart/stimuli-responsive hydrogels: Cutting-edge platforms for tissue engineering and other biomedical applications

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