2022
DOI: 10.1016/j.mtbio.2021.100186
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Abstract: Recently, biomedicine and tissue regeneration have emerged as great advances that impacted the spectrum of healthcare. This left the door open for further improvement of their applications to revitalize the impaired tissues. Hence, restoring their functions. The implementation of therapeutic protocols that merge biomimetic scaffolds, bioactive molecules, and cells plays a pivotal role in this track. Smart/stimuli-responsive hydrogels are remarkable three-dimensional (3D) bioscaffolds intended for tissue engine… Show more

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Cited by 138 publications
(108 citation statements)
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References 454 publications
(621 reference statements)
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“…Additionally, GIT conditions set a baseline to guide the required physicochemical properties for designing novel encapsulates. While in some cases, the harsh conditions of the GIT and its innate reactive stimuli appeared as a major obstacle to reaching the site of action of several encapsulates (Figure 1), novel engineering approaches have considered responses to such stimuli for the development of polymeric networks programmed to undergo volume changes, structural transitions, partial degradation, and structural network rearrangements [24]. Thus, the proper understating of the ionic strength, redox potential, pH, and enzymatic stimuli [25,26] present in the GIT is essential to rationally design multi-structured matrices capable of active response to the conditions of each GIT component while protecting the probiotic cargoes [27].…”
Section: Gastrointestinal Tract (Git) Stimuli As Tool For Designmentioning
confidence: 99%
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“…Additionally, GIT conditions set a baseline to guide the required physicochemical properties for designing novel encapsulates. While in some cases, the harsh conditions of the GIT and its innate reactive stimuli appeared as a major obstacle to reaching the site of action of several encapsulates (Figure 1), novel engineering approaches have considered responses to such stimuli for the development of polymeric networks programmed to undergo volume changes, structural transitions, partial degradation, and structural network rearrangements [24]. Thus, the proper understating of the ionic strength, redox potential, pH, and enzymatic stimuli [25,26] present in the GIT is essential to rationally design multi-structured matrices capable of active response to the conditions of each GIT component while protecting the probiotic cargoes [27].…”
Section: Gastrointestinal Tract (Git) Stimuli As Tool For Designmentioning
confidence: 99%
“…Among the commonly found chemical stimuli present in the GIT, ionic strength and reduction-oxidation (redox) potency provide crucial cues for in situ extracellular matrix changes as a function of the systemic response of mammalian body functions [24]. Thus, the existence of monovalent and bivalent ions as well as reactive oxygen species (ROS) and nitrogen-oxygen species (NOS) are produced under different ionic strength and redox conditions, and therefore represent an addressable route to ionize polymeric structures [36].…”
Section: Ionic Strength and Redox Potentialmentioning
confidence: 99%
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