Low-cost luminescent scaffolds-based on thiol chitosans by microwave radiation for vertebral disc repair/theragnostic

Borsagli, Fernanda Guerra Lima Medeiros; Rodrigues, Jordane S.; Aguiar, Rafaella Azevedo; Paiva, Aislan Esmeraldo; Vasquez, Jhonattan Frank Baez; Ramos, Welyson T.S.; Allibrandini, Paulo; Rocha, Elém Patrícia Alves; Gonçalves, Max P.; Souza, Fidel Edson de

doi:10.1016/j.ijbiomac.2022.04.191

Cited by 9 publications

(3 citation statements)

References 29 publications

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“…Because chitosan is water-soluble and easily forms ionic and hydrogen bonds with drug structures, it can be widely used in drug delivery systems, cancer therapy, wound healing and tissue engineering [76]. To maximize the therapeutic potential and bioavailability of drugs in a controlled and continuous manner [77], various micro-and nanoparticles have been developed as their active carriers [78,79], hydrogels [80][81][82][83] scaffolds [84][85][86][87] and organic or inorganic matrices based on chitosan or chitin [88].…”

Section: Chitin/chitosanmentioning

confidence: 99%

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Chelu,

Musuc

2023

Processes

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Biomaterials are mostly any natural and synthetic materials which are compatible from a biological point of view with the human body. Biomaterials are widely used to sustain, increase, reestablish or substitute the biological function of any injured tissue and organ from the human body. Additionally, biomaterials are uninterruptedly in contact with the human body, i.e., tissue, blood and biological fluids. For this reason, an essential feature of biomaterials is their biocompatibility. Consequently, this review summarizes the classification of different types of biomaterials based on their origin, as natural and synthetic ones. Moreover, the advanced applications in pharmaceutical and medical domains are highlighted based on the specific mechanical and physical properties of biomaterials, concerning their use. The high-priority challenges in the field of biomaterials are also discussed, especially those regarding the transfer and implementation of valuable scientific results in medical practice.

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Section: Chitin/chitosanmentioning

confidence: 99%

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Chelu,

Musuc

2023

Processes

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“…A visual component can give real-time feedback on drug delivery, release, accumulation, and pharmacokinetics, enabling the patient's medical treatment to be monitored and optimized rationally throughout the entire treatment. 155,156 Recently, DNA hydrogels have shown significant promise as stimuli-responsive drug delivery platforms. The DNA hydrogel can adapt to various environments due to its programmability.…”

Section: Theragnostic Applicationsmentioning

confidence: 99%

DNA hydrogels and nanogels for diagnostics, therapeutics, and theragnostics of various cancers

Zare¹,

Taheri‐Ledari²,

Esmailzadeh³

et al. 2023

Nanoscale

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“…[ 74 ] Borsagli et al. [ 75 ] introduced a thiolated chitosan‐based 3D scaffold with luminescence by microwave radiation using 11‐mercaptoundecanoic acid and cysteine for IVD theragnostic and regeneration. The scaffold facilitated outstanding cell viability and showed the possibility of evaluating greater compression points in the IVD, providing the potential for tissue engineering applications.…”

Section: Implantation and Recoverymentioning

confidence: 99%

Repair Strategies and Bioactive Functional Materials for Intervertebral Disc

Zhou

et al. 2022

Adv Funct Materials

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Intervertebral disc (IVD) degeneration is the leading cause of low back pain, which represents a highly prevalent chronic aging-associated disorder with a large socio-economic burden and a great decline in the quality of life, contributing to the pressing need for IVD treatments. Thus, finding effective disease-modifying approaches for postponing the progression of IVD degeneration and repairing degenerated intervertebral discs is of great importance, even facing various challengeable obstacles. Bioactive functional materials exhibit excellent advances in modulating cell activity and remodeling tissue homeostasis, which acts as a promising and accessible therapeutic approach to tissue repair and organ reconstruction. Recently, these have been notably explored to investigate bioactive functional materials-based repair strategies for intervertebral disc recovery and regeneration, including cell-based tissue engineering, the development of implants for disc recovery, and therapeutic methods for remodeling the functional integrity of the IVD. This review summarizes the advanced progress of bioactive functional materials in IVD repair and regeneration, and discusses their regulatory mechanisms, limitations, challenges as well as their clinical translational prospects in the future.

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Low-cost luminescent scaffolds-based on thiol chitosans by microwave radiation for vertebral disc repair/theragnostic

Cited by 9 publications

References 29 publications

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

DNA hydrogels and nanogels for diagnostics, therapeutics, and theragnostics of various cancers

Repair Strategies and Bioactive Functional Materials for Intervertebral Disc

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