Low cost lab-on-a-chip prototyping with a consumer grade 3D printer

Comina, Germán; Suska, Anke; Filippini, Daniel

doi:10.1039/c4lc00394b

Cited by 123 publications

(130 citation statements)

References 35 publications

Supporting

Mentioning

128

Contrasting

Order By: Relevance

“…The possible applications are numerous, such as titanium scaffolds for orthopaedic implants [1], complex biomedical devices [2], optic components [3], lab-on-a-chip devices [4], and aerial vehicle wing structures [5], to name but a few recent developments. Besides the fast-growing markets for additive manufactured biomaterials and engineered structures, 3D printing also opens a cheap and simple route to produce individual, customised components for scientific use [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Dielectric Properties of 3D Printed Polylactic Acid

Dichtl

Sippel

Krohns

2017

Advances in Materials Science and Engineering

View full text Add to dashboard Cite

3D printers constitute a fast-growing worldwide market. These printers are often employed in research and development fields related to engineering or architecture, especially for structural components or rapid prototyping. Recently, there is enormous progress in available materials for enhanced printing systems that allow additive manufacturing of complex functional products, like batteries or electronics. The polymer polylactic acid (PLA) plays an important role in fused filament fabrication, a technique used for commercially available low-budget 3D printers. This printing technology is an economical tool for the development of functional components or cases for electronics, for example, for lab purposes. Here we investigate if the material properties of “as-printed” PLA, which was fabricated by a commercially available 3D printer, are suitable to be used in electrical measurement setups or even as a functional material itself in electronic devices. For this reason, we conduct differential scanning calorimetry measurements and a thorough temperature and frequency-dependent analysis of its dielectric properties. These results are compared to partially crystalline and completely amorphous PLA, indicating that the dielectric properties of “as-printed” PLA are similar to the latter. Finally, we demonstrate that the conductivity of PLA can be enhanced by mixing it with the ionic liquid “trihexyl tetradecyl phosphonium decanoate.” This provides a route to tailor PLA for complex functional products produced by an economical fused filament fabrication.

show abstract

Section: Introductionmentioning

confidence: 99%

Dielectric Properties of 3D Printed Polylactic Acid

Dichtl

Sippel

Krohns

2017

Advances in Materials Science and Engineering

View full text Add to dashboard Cite

show abstract

“…20,21 In addition, with a proper device design, accessories can be assembled to the 3D printed devices after they are built/printed so that additional functions can be added to the 3D printed devices. 7,18,[22][23][24] Furthermore, direct multi-material 3D printing using different polymers, e.g., soft and rigid polymers, from a 3D CAD model has also been demonstrated. 25 Clearly, the unique method of printing 3D structures could have huge potential and competitive advantages over the traditional fabrication or manufacturing processes.…”

Section: Introductionmentioning

confidence: 99%

Embedding objects during 3D printing to add new functionalities

Yuen

2016

Biomicrofluidics

View full text Add to dashboard Cite

A novel method for integrating and embedding objects to add new functionalities during 3D printing based on fused deposition modeling (FDM) (also known as fused filament fabrication or molten polymer deposition) is presented. Unlike typical 3D printing, FDM-based 3D printing could allow objects to be integrated and embedded during 3D printing and the FDM-based 3D printed devices do not typically require any post-processing and finishing. Thus, various fluidic devices with integrated glass cover slips or polystyrene films with and without an embedded porous membrane, and optical devices with embedded Corning V R Fibrance TM Light-Diffusing Fiber were 3D printed to demonstrate the versatility of the FDMbased 3D printing and embedding method. Fluid perfusion flow experiments with a blue colored food dye solution were used to visually confirm fluid flow and/or fluid perfusion through the embedded porous membrane in the 3D printed fluidic devices. Similar to typical 3D printed devices, FDM-based 3D printed devices are translucent at best unless post-polishing is performed and optical transparency is highly desirable in any fluidic devices; integrated glass cover slips or polystyrene films would provide a perfect optical transparent window for observation and visualization. In addition, they also provide a compatible flat smooth surface for biological or biomolecular applications. The 3D printed fluidic devices with an embedded porous membrane are applicable to biological or chemical applications such as continuous perfusion cell culture or biocatalytic synthesis but without the need for any post-device assembly and finishing. The 3D printed devices with embedded Corning V R Fibrance TM Light-Diffusing Fiber would have applications in display, illumination, or optical applications. Furthermore, the FDMbased 3D printing and embedding method could also be utilized to print casting molds with an integrated glass bottom for polydimethylsiloxane (PDMS) device replication. These 3D printed glass bottom casting molds would result in PDMS replicas with a flat smooth bottom surface for better bonding and adhesion. Published by AIP Publishing. [http://dx

show abstract

“…Here, we discuss the latest results on LOC devices fabricated with consumer-grade SL 3D printers, and, in particular, the concept of unibody LOC (ULOC [10]) and its possibility to integrate essential components and LOC principles. The ULOC concept is inspired by Apple ® 's (Cupertino, CA, USA) unibody design, which is used to fabricate the body of such computers.…”

Section: Introductionmentioning

confidence: 99%

“…Emerging additive 3D structuring, like in thermoplastic extrusion systems [5][6][7] and micro-stereo lithography (SL) platforms [3,[7][8][9][10], have the potential to greatly simplify fabrication and minimize infrastructure costs.…”

Section: Introductionmentioning

confidence: 99%

3D Printed Unibody Lab-on-a-Chip: Features Survey and Check-Valves Integration

2015

Self Cite

View full text Add to dashboard Cite

Abstract:The unibody lab-on-a-chip (ULOC) concept entails a fast and affordable micro-prototyping system built around a single monolithic 3D printed element (unibody). A consumer-grade stereo lithography (SL) 3D printer can configure ULOCs with different forms of sample delivery, transport, handling and readout, while minimizing material costs and fabrication time. ULOC centralizes all complex fabrication procedures and replaces the need for clean room resources, delivering prototypes for less than 1 US$, which can be printed in 10 min and ready for testing in less than 30 min. Recent examples of ULOC integration of transport, chemical sensing for optical readout and flow mixing capabilities are discussed, as well as the integration of the first check-valves for ULOC devices. ULOC valves are strictly unidirectional up to 100 psi, show an exponential forward flow behavior up to 70 psi and can be entirely fabricated with the ULOC approach.

show abstract

Low cost lab-on-a-chip prototyping with a consumer grade 3D printer

Cited by 123 publications

References 35 publications

Dielectric Properties of 3D Printed Polylactic Acid

Dielectric Properties of 3D Printed Polylactic Acid

Embedding objects during 3D printing to add new functionalities

3D Printed Unibody Lab-on-a-Chip: Features Survey and Check-Valves Integration

Contact Info

Product

Resources

About