Low-cost, high-speed identification of counterfeit antimalarial drugs on paper

Koesdjojo, Myra T.; Wu, Yuanyuan; Boonloed, Anukul; Dunfield, Elizabeth M.; Remcho, Vincent T.

doi:10.1016/j.talanta.2014.05.050

Cited by 51 publications

(30 citation statements)

References 16 publications

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“…In this configuration, three zones were selected as control zones (labelled as zones 1-3) and five zones were selected to obtain the colorimetric response for the nitrite assay (labelled as zones [4][5][6][7][8]. In this configuration, three zones were selected as control zones (labelled as zones 1-3) and five zones were selected to obtain the colorimetric response for the nitrite assay (labelled as zones [4][5][6][7][8].…”

Section: Nitrite Assaysmentioning

confidence: 99%

“…PADs have been used for different applications in association with electrochemical 20, 21 , mass spectrometry 22,23 and colorimetric detection 8,24 . The latter is one of the most popular detectors on PADs due to its global affordability and capability of capturing digital images with benchtop and handheld electronic devices 6,25,26 . Furthermore, the portability of electronic devices like cell phone camera, webcam, digital cameras, or handheld scanners allows their use for on-site applications.…”

Section: Introductionmentioning

confidence: 99%

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Colorimetric determination of nitrite in clinical, food and environmental samples using microfluidic devices stamped in paper platforms

2015

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This study reports the use of microfluidic paper-based analytical devices (µPADs) associat e d with colorimetric detection for the determination of nitrite in clinical, food and environment a l samples. µPADs were fabricat ed by simple and fast stamping process in a geomet ry containin g eight circular detection zones and one central zone to sample inlet interconnected by microfluid i c channels . The colorimet ric determination of nitrite was performed through the modified Gries s reaction. Detection zones were spotted with a 0.75 µL aliquot of a solution containing 50 mmol L -1 sulfanilamide, 1.2 mol L -1 hydrochloric acid and 4 mmol L -1 N-(1-napthyl)ethy lenediamin e . The monitoring of the background colorimetric response revealed good stability over 12h for devices stored in the absence of light. After the addition of standard or real samples, the result in g images were captured with a scanner, converted to a color scale and analyzed in the magen t a channel. The analytical sensitivity and the limit of detection achieved after a preconcentrat io n stage were 0.56 (AU/µM ) and 5.6 µM , respectively. The preconcentrat ion provided an enrichment factor of ca. 3.2 times. The concentration levels of nitrite were successful ly determined in saliva, preservative water, ham, sausage and river water samples. The concentrat ion levels attained for each sample using µPADs were compared to the values found by spectrophotomet ry and there was no significative difference from one another at a confiden c e level of 95%.

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Section: Nitrite Assaysmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Colorimetric determination of nitrite in clinical, food and environmental samples using microfluidic devices stamped in paper platforms

2015

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“…[4][5][6][7][8][9][10][11][12][13] However, last few decades witnessed an upsurge in electrochemical methods for the detection and determination of these compounds. Therapeutic drug monitoring (TDM) is a clinical strategy that measures drug concentration in a patient's bloodstream to monitor its compliance, efficacy and toxicity, thus optimizing and managing individual medication regimen.…”

Section: Introductionmentioning

confidence: 99%

Research progress in electroanalytical techniques for determination of antimalarial drugs in pharmaceutical and biological samples

et al. 2016

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“…Various formats of membrane-based test strips, dry chemistry slides and paper microfluidic devices, all designed to utilize smaller amounts of samples and reagents while producing faster results (often with enhanced sensitivity) have been examined for medical diagnostics and other applications [6][7][8]. To further these efforts, parallel projects have been pursued to develop detection approaches that can match the simplicity and low cost of these paper strip approaches.…”

Section: Introductionmentioning

confidence: 99%

Clinical chemistry measurements with commercially available test slides on a smartphone platform: Colorimetric determination of glucose and urea

Boonloed

Sleszynski

et al. 2015

Clinica Chimica Acta

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Low-cost, high-speed identification of counterfeit antimalarial drugs on paper

Cited by 51 publications

References 16 publications

Colorimetric determination of nitrite in clinical, food and environmental samples using microfluidic devices stamped in paper platforms

Colorimetric determination of nitrite in clinical, food and environmental samples using microfluidic devices stamped in paper platforms

Research progress in electroanalytical techniques for determination of antimalarial drugs in pharmaceutical and biological samples

Clinical chemistry measurements with commercially available test slides on a smartphone platform: Colorimetric determination of glucose and urea

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