Low contribution of n-3 polyunsaturated fatty acids to plasma and erythrocyte membrane lipids in diabetic young adults

Fatty Acid Composition of Plasma Lipid Classes in Chronic Alcoholic Pancreatitis

“…Because in our previous study on diabetic adults (without CP) we found significant differences in LCPUFA status [14], we excluded patients with diabetes from the present study. Hence, our present data may be evaluated in parallel with the data of Quilliot et al [13] on their patients with CP but without diabetes.…”

Diabetic retinopathy: Breaking the barrier

“…In addition to hyperglycemic conditions, the alteration in retinal fatty acid metabolism, possibly via AGE/RAGE interactions and the activation of the MAPK pathway, can lead to chronic inflammation due to a decrease in retinal n-3 polyunsaturated fatty acids (PUFAs), such as docosohexanoic acid (DHA) [121]. Moreover, the increase in n6 essential fatty acid (EFA) levels, such as with linoleic acid in diabetes, may stimulate inflammation in the diabetic retina [122, 123]. In addition to its possible role in dyslipidemia, AGE/RAGE interactions may lead to vascular endothelial cell activation, upregulation of ICAM-1 and E-selectin expression, and increased leukostasis [124].…”

Eicosapentaenoic acid as an add-on to antidepressant medication for co-morbid major depression in patients with diabetes mellitus: A randomized, double-blind placebo-controlled study

“…One candidate that could improve treatment success may be longer chain ω-3 polyunsaturated fatty acids (PUFAs) from fatty fish, including eicosapentaenoic acid (EPA; C20:5 ω-3) and docosahexaenoic acid (DHA; C22:6 ω-3) (Pouwer et al, 2005). Both depressed patients and diabetic patients are known to have relatively low levels of ω-3 PUFAs (Decsi et al, 2007;Sontrop and Campbell, 2006;Vessby, 2000). A recent meta-analysis showed that ω-3 PUFAs were efficacious as antidepressant therapy (Appleton et al, 2010) , although heterogeneity in study design was noted.…”