Fatty Acid Composition of Plasma Lipid Classes in Chronic Alcoholic Pancreatitis

Marosvölgyi, Tamás; Horváth, Gábor; Dittrich, Aniko; Cseh, Judit; Lelovics, Zsuzsanna; Szabó, Éva; Décsi, Támas; Figler, Mária

doi:10.1159/000289466

Cited by 8 publications

(6 citation statements)

References 15 publications

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“…In addition, blood samples were obtained while patients were nonfasting, and nutritional intake was not recorded, which may have contributed to variances in our data, particularly in linoleic acid. 7,8,49 However, our data align with previously published studies suggesting there is a dysregulation of linoleic acid metabolism, indicated by increased metabolites in CP, 53 or a reduction in linoleic acid absorption, and an increased de novo lipogenesis in CP and changes of FA composition, including linoleic acid, in diabetes and CP. 6,8 Unexpectedly, we did not observe any differences in FA composition in CP with and without EPD, often seen in patients with cystic fibrosis-associated pancreatitis.…”

Section: Discussionsupporting

confidence: 91%

“…Substance abuse is another important etiologic risk factor for developing CP. Several studies have shown polyunsaturated FAs (PUFAs) like linoleic acid are decreased and MUFAs like oleic acid are increased in patients with CP who had a history of excessive alcohol consumption compared with healthy controls 7,49,50 ; however, many of these studies do not address how smoking affects FAs in patients who already have CP. In our study, we confirm that linoleic acid decreased, and oleic acid increased with alcohol use in patients with CP.…”

Section: Discussionmentioning

confidence: 99%

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Differences in Plasma Fatty Acid Composition Related to Chronic Pancreatitis

Gumpper-Fedus,

Crowe,

Hart

et al. 2024

Pancreas

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Objectives Chronic pancreatitis (CP) is an inflammatory disease affecting the absorption of fat-soluble nutrients. Signaling in pancreatic cells that lead to inflammation may be influenced by fatty acids (FAs) through diet and de novo lipogenesis. Here, we investigated the relationship between plasma FA composition in CP with heterogeneity of etiology and complications of CP. Materials and Methods Blood and clinical parameters were collected from subjects with CP (n = 47) and controls (n = 22). Plasma was analyzed for FA composition using gas chromatography and compared between controls and CP and within CP. Results Palmitic acid increased, and linoleic acid decreased in CP compared with controls. Correlations between age or body mass index and FAs are altered in CP compared with controls. Diabetes, pancreatic calcifications, and substance usage, but not exocrine pancreatic dysfunction, were associated with differences in oleic acid and linoleic acid relative abundance in CP. De novo lipogenesis index was increased in the plasma of subjects with CP compared with controls and in calcific CP compared with noncalcific CP. Conclusions Fatty acids that are markers of de novo lipogenesis and linoleic acid are dysregulated in CP depending on the etiology or complication. These results enhance our understanding of CP and highlight potential pathways targeting FAs for treating CP.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Differences in Plasma Fatty Acid Composition Related to Chronic Pancreatitis

Gumpper-Fedus,

Crowe,

Hart

et al. 2024

Pancreas

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“…It has been communicated that patients with alcoholic pancreatitis showed an increase of monounsaturated fatty acids and a decrease of AA in plasma phosholipids compared to controls, while no differences were observed in values of EPA and DHA or in the ratio of ( n − 3) to ( n − 6) long chain-PUFA [44]. …”

Section: Importance Of Dietary Fatty Acids On Phospholipid Distributimentioning

confidence: 99%

Nutritional Deficiencies and Phospholipid Metabolism

Giménez

Oliveros

Gómez

2011

IJMS

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Phospholipids are important components of the cell membranes of all living species. They contribute to the physicochemical properties of the membrane and thus influence the conformation and function of membrane-bound proteins, such as receptors, ion channels, and transporters and also influence cell function by serving as precursors for prostaglandins and other signaling molecules and modulating gene expression through the transcription activation. The components of the diet are determinant for cell functionality. In this review, the effects of macro and micronutrients deficiency on the quality, quantity and metabolism of different phospholipids and their distribution in cells of different organs is presented. Alterations in the amount of both saturated and polyunsaturated fatty acids, vitamins A, E and folate, and other micronutrients, such as zinc and magnesium, are discussed. In all cases we observe alterations in the pattern of phospholipids, the more affected ones being phosphatidylcholine, phosphatidylethanolamine and sphingomyelin. The deficiency of certain nutrients, such as essential fatty acids, fat-soluble vitamins and some metals may contribute to a variety of diseases that can be irreversible even after replacement with normal amount of the nutrients. Usually, the sequelae are more important when the deficiency is present at an early age.

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“…2,22,40 Several studies have shown FAs like linoleic acid as well as other fatty acids in its metabolic pathway are dysregulated in patients with CP who had a history of excessive alcohol consumption compared to healthy controls. 7,41,42 In our study, the relative abundance of linoleic acid was decreased and oleic acid was increased due to alcohol use, and only linoleic acid was affected by a history of smoking in CP. Linoleic acid metabolism can result in an increase of prostaglandins that promote inflammation.…”

Section: Discussionmentioning

confidence: 46%

“…Additionally, blood samples were obtained while patients were non-fasting, and nutritional intake was not recorded, which may have contributed to variances in our data compared to others did. 7,8,41 We were also unable to assess FA changes due to other potential metabolic disorders such as hyperlipidemia.…”

Section: Discussionmentioning

confidence: 99%

Changes in Plasma Fatty Acid Abundance Related to Chronic Pancreatitis: A Pilot Study

Gumpper

Crowe

Hart

et al. 2023

Preprint

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Objectives: Chronic pancreatitis (CP) is an inflammatory disease that affects the absorption of nutrients like fats. Molecular signaling in pancreatic cells can be influenced by fatty acids (FAs) and changes in FA abundance could impact CP-associated complications. Here, we investigated FA abundance in CP compared to controls and explored how CP-associated complications and risk factors affect FA abundance. Methods: Blood and clinical parameters were collected from subjects with (n=47) and without CP (n=22). Plasma was analyzed for relative FA abundance using gas chromatography and compared between controls and CP. Changes in FA abundance due to clinical parameters were also assessed in both groups. Results: Decreased relative abundance of polyunsaturated fatty acids (PUFAs) and increased monounsaturated fatty acids (MUFAs) were observed in subjects with CP in a sex-dependent manner. The relative abundance of linoleic acid increased, and oleic acid decreased in CP subjects with exocrine pancreatic dysfunction and a history of substance abuse. Conclusions: Plasma FAs like linoleic acid are dysregulated in CP in a sex-dependent manner. Additionally, risk factors and metabolic dysfunction further dysregulate FA abundance in CP. These results enhance our understanding of CP and highlight potential novel targets and metabolism-related pathways for treating CP.

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Fatty Acid Composition of Plasma Lipid Classes in Chronic Alcoholic Pancreatitis

Cited by 8 publications

References 15 publications

Differences in Plasma Fatty Acid Composition Related to Chronic Pancreatitis

Differences in Plasma Fatty Acid Composition Related to Chronic Pancreatitis

Nutritional Deficiencies and Phospholipid Metabolism

Changes in Plasma Fatty Acid Abundance Related to Chronic Pancreatitis: A Pilot Study

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