Low carbohydrate, high protein diet promotes atherosclerosis in apolipoprotein E/low-density lipoprotein receptor double knockout mice (apoE/LDLR−/−)

Characterisation of atherogenic effects of low carbohydrate, high protein diet (LCHP) in apoE/LDLR−/− mice

“…In our previous work, using another model of genetically modified hyperlidemic mice such as apoE/LDLR -/-mice (7) we confirmed that the LCHP diet significantly increased the extent of advanced atherosclerosis in the aortic root and may promote plaque vulnerability. We also demonstrated that LCHP-fed apoE/LDLR -/-mice developed more extensive atherosclerosis than WD-fed mice, despite similar dietary fat and cholesterol contents but in our previous work we did not provide insight into mechanisms of pro-atherogenic effects of LCHP diet.…”

Gammadelta (γδ) T lymphocytes do not impact the development of early atherosclerosis

“…2B). To investigate the role of γδ T cells in atherosclerosis, age- and gender-matched ApoE −/− and TCRδ −/− ApoE −/− mice were fed a Western diet for 10 weeks [12,13]. Aortas of these mice were perfused to rid the tissue of blood cells, isolated, and used for either flow cytometric analysis or atherosclerotic lesion quantification.…”

Popular diets and over-the-counter dietary aids and their effectiveness in managing obesity

“…[43][44][45] A recent meta-analysis of long-term randomised control trials, repor ted that such diets have neither specific bene fi cial nor detri mental effects on outcome markers of obesity, cardi ovas cu lar disease or glycaemic control. 46 Others disagree -at least in mice 47,48 and in results of cohort studies. Two cohort studies from the United States have repor ted that a low carbohydrate diet, high in animal protein was asso ci ated with higher all-cause mortal ity in both men and women, but not if the protein was mainly from plant sources.…”