Low bone mineral density in adult patients with moderate to severe atopic dermatitis

Haeck, Inge; Hamdy, Neveen A. T.; Mik, L. Timmer-de; Lentjes, E G W M; Verhaar, Harald J. J.; Knol, Mirjam J.; Bruin‐Weller, Marjolein S. de; Bruijnzeel-Koomen, C

doi:10.1111/j.1365-2133.2009.09327.x

Cited by 42 publications

(43 citation statements)

References 30 publications

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“…Low bone mineral density was found in adult patients with moderate to severe atopic dermatitis, a chronic inflammatory skin disease [19]. Animal study showed when JunB was constitutively deleted from epidermal keratinocytes, a multi-organ disease developed affecting the skin, the hematopoietic system as well as the bone compartment [20].…”

Section: Discussionmentioning

confidence: 98%

Loss-of-function of SHARPIN causes an osteopenic phenotype in mice

Xia¹,

Liang

Ma³

et al. 2010

Endocr

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SHARPIN is a novel protein thought to interact with SHANK family and is widely expressed in multiple tissues/cells, including osteoblasts and osteoclasts. Loss-of-function of Sharpin develops the chronic proliferative dermatitis mutation (CPDM) in mice as well as a severe inflammation in other organs. The actual function of SHARPIN is poorly understood. Our aim was to determine the functional roles of SHARPIN in bone metabolism by using CPDM mice. The skeletal phenotypes were determined by peripheral quantitative computed tomography, micro-computed tomography, and quantitative real-time RT-PCR, the cellular functions of osteoblasts and osteoclasts were investigated by ex vivo cell culture. Compared to wild-type controls, CPDM mice demonstrated significantly lower total and cortical bone mineral content and bone mineral density, trabecular and cortical bone volume, and trabecular number. The mRNA expression of Runx2, osterix, type I collagen, and osteocalcin was significantly lower in the bone from CPDM mice. Osteoclasts and osteoblasts from CPDM mice were functionally defective. Our result suggests that SHARPIN plays important regulating roles in bone metabolism. These functional roles may either come from systemic chronic inflammatory or directly signaling pathway within bone cells.

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Section: Discussionmentioning

confidence: 98%

Loss-of-function of SHARPIN causes an osteopenic phenotype in mice

Xia¹,

Liang

Ma³

et al. 2010

Endocr

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“…6 Osteoporosis and osteopenia were detected in 4.8% and 32.8% of 125 adults with moderate-to-severe eczema, respectively. 31 Low BMD in these patients did not seem to respond to calcium and/or vitamin D supplementation. 32 Another small adult study found similar BMD between subjects with eczema and controls.…”

Section: Discussionmentioning

confidence: 99%

Assessment of dietary food and nutrient intake and bone density in children with eczema

et al. 2017

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“…In addition, the chronic inflammation associated with eczema may predispose toward bone loss, as described in patients with rheumatoid arthritis and inflammatory bowel disease. 20,21 A 2009 study 22 found low BMD in approximately one-third of patients with moderate to severe atopic dermatitis (AD). Therefore, studies describing the prevalence of fracture among adults with eczema are needed.…”

mentioning

confidence: 99%