Assessment of dietary food and nutrient intake and bone density in children with eczema

Leung, Ting‐Fan; Wang, S S; Kwok, F Yy; Leung, Lawrence W.; Chow, Chung-Mo; Hon, Kam Lun

doi:10.12809/hkmj164684

Cited by 6 publications

(8 citation statements)

References 33 publications

(40 reference statements)

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“…Perylenequinones are produced by a variety of fungal species, particularly by plant pathogens that cause damage to plant tissues . Light-activated hypocrellins exhibited a broad range of toxicities against bacteria, fungi, and human tumor cells. ,,, As such, obvious questions pertain to how fungi that biosynthesize hypocrellins protect themselves against their own toxins or how light exposure facilitates the biosynthesis of these compounds without a noticeable decrease in fungal growth and development. Although the mechanisms of protection against autotoxicity have not been reported for these fungi, Cercospora spp.…”

Section: Resultsmentioning

confidence: 99%

Enhanced Production and Anticancer Properties of Photoactivated Perylenequinones

et al. 2020

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Hypocrellins and hypomycins are naturally occurring fungal perylenequinones with potential photodynamic activity against cancer and microbial diseases. This project pursued three lines of research. First, the production of perylenequinones was enhanced by investigating the effect of culture medium and light exposure on their biosynthesis. Solid-fermentation cultures on rice medium allowed for enhanced production of hypocrellins as compared to Cheerios or oatmeal medium. Alternatively, increased production of hypomycins, which are structurally related to the hypocrellins, was observed on oatmeal medium. In both cases, light exposure was an essential factor for the enhanced biosynthesis. In addition, this led to the discovery of two new perylenequinones, ent-shiraiachrome A (5) and hypomycin E (8), which were elucidated based on spectroscopic data. Finally, the photocytotoxic effects of both classes of compounds were evaluated against human skin melanoma, with EC 50 values at nanomolar levels for hypocrellins and micromolar levels for hypomycins. In contrast, both classes of compounds showed reduced dark toxicity (EC 50 values >100 μM), demonstrating promising phototherapeutic indices.

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Section: Resultsmentioning

confidence: 99%

Enhanced Production and Anticancer Properties of Photoactivated Perylenequinones

et al. 2020

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“…In a cross‐sectional study conducted among children less than 18 years of age in Hong Kong, there was no difference in BMD of the radius and tibia in those with eczema compared to controls 13 . In contrast, a cross‐sectional study of 3039 children and adolescents ages 8–19 years in the United States found that AD was associated with significantly lower BMD z ‐scores, after adjusting for covariates including age, sex, race/ethnicity, level of education and household income, BMI and smoking in the household 14 …”

Section: Resultsmentioning

confidence: 94%

Atopic dermatitis and bone health: a systematic review

Mukovozov

Morra

Giustini

et al. 2020

Acad Dermatol Venereol

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Atopic dermatitis (AD) is associated with systemic inflammation and systemic corticosteroid use which can lead to poor bone health. The aim of this systematic review is to investigate the relationship between AD and bone mineral density (BMD), osteoporosis and fractures. We searched Web of Science, Cochrane Database of Systematic Reviews, MEDLINE and Embase. Title, abstract and full‐text screening, and data extraction were done in duplicate. Quality appraisal was performed using the Agency for Healthcare Research and Quality Methodology Checklist (cross‐sectional studies) and Newcastle‐Ottawa Scale (cohort studies). We screened 3800 abstracts and included fifteen studies (twelve cross‐sectional, three cohort). In cross‐sectional studies, AD was associated with decreased BMD and increased fractures. In cross‐sectional studies and a cohort study, AD was associated with a higher prevalence of osteoporosis compared to controls. There was inconsistency across studies, with some finding no association. In a large cohort study, AD was associated with increased risk of fractures of the hip (HR: 1.06, 95% CI: 1.02 to 1.11), spine (HR: 1.14, 95% CI: 1.06 to 1.23) and wrist (HR: 1.06, 95% CI: 1.01 to 1.10), with further increased risk with more severe AD. Differences between studies precluded quantitative synthesis. There is some evidence supporting an association between AD and poor bone health. Research is needed to clarify this association, underlying mechanisms and develop strategies to improve bone health of individuals with AD.

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“…After removing duplicates, 963 records remained, and 943 records were further excluded after reviewing their titles and abstracts. The full texts of the remaining 20 records were carefully scrutinized for eligibility, and ten studies met the inclusion criteria and were included in the qualitative synthesis (5)(6)(7)(8)(9)(10)(11)(12)(13)(14).…”

Section: Study Selectionmentioning

confidence: 99%

“…During the past years, there is growing evidence that suggests that people who suffer from AD are more likely to have a lower bone mineral density (BMD), higher prevalence of osteopenia, osteoporosis, and related fractures when compared with those without AD (5)(6)(7)(8)(9). However, evidence of the potential association between AD and abnormalities in the bone mineral metabolism remains fragmented (10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Bone mineral density, osteopenia, osteoporosis, and fracture risk in patients with atopic dermatitis: a systematic review and meta- analysis

Wu¹,

Wu²,

Zhou³

et al. 2021

Ann Transl Med

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Background: The relationship between atopic dermatitis (AD) and abnormal bone metabolism remains unclear. We performed a systematic review and meta-analysis to determine whether patients with AD were associated with increased risks of low bone mineral density (BMD), osteopenia, osteoporosis, and related fractures.Methods: We searched PubMed, Embase, and the Cochrane Library through December 2019 to identify studies that investigated the association between AD and abnormal bone metabolism (including BMD, osteopenia, osteoporosis, and related fractures). The predefined primary outcome was related fractures; secondary outcomes included osteoporosis, osteopenia, and BMD. We calculated the summary odds ratios (ORs) and 95% confidence intervals (CIs) using a random-effects model.Results: Ten studies were included in this systematic review. In children and adolescents, four studies investigated the association between AD and BMD; three studies indicated that children and adolescents with AD were associated with an increased risk of low BMD; one study found similar BMD between AD and control groups. In adults, three studies assessed the risk of fracture and were included in the meta-analysis, comprising 562,405 AD patients among 3,171,268 participants. Adults with AD were associated with an increased risk of fracture (OR 1.13; 95% CI, 1.05-1.22; P=0.001). Three studies investigated the association between AD and osteoporosis, which suggested that patients with AD were associated with an increased risk of osteoporosis (OR 1.95; 95% CI, 1.18-3.23; P=0.009). Further, patients with AD were associated with increased risks of osteopenia (OR 1.90; 95% CI, 1.51-2.38; P<0.001) and low BMD at the femur and spine.Conclusions: Patients with AD were associated with increased risks of low BMD, osteopenia, osteoporosis, and related fractures. Both clinical studies and basic research are needed to clarify the mechanisms of association between AD and abnormal bone metabolism.

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Assessment of dietary food and nutrient intake and bone density in children with eczema

Cited by 6 publications

References 33 publications

Enhanced Production and Anticancer Properties of Photoactivated Perylenequinones

Enhanced Production and Anticancer Properties of Photoactivated Perylenequinones

Atopic dermatitis and bone health: a systematic review

Bone mineral density, osteopenia, osteoporosis, and fracture risk in patients with atopic dermatitis: a systematic review and meta- analysis

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