Low Bone Mass in Premenopausal Women With Depression

Depressive Symptoms, Bone Loss, and Fractures in Postmenopausal Women

“…1,2 Both conditions have multifaceted etiologies, but have physiologic processes in common that could provide biologic plausibility for an association. Corticosteroids, cytokines, and serotonin have been postulated to play a role in both depression [3][4][5][6] and bone homeostasis. [7][8][9][10][11] Alternatively, the link could be caused by factors associated with depression that affect bone health such as inactivity, nutrition, weight, calcium intake, or smoking.…”

Vitamin D Levels and Vitamin D Receptor Gene Polymorphism in Major Depression

“…Some studies have demonstrated that 25 (OH) D which is thought to be a more reliable marker in the determination of vitamin D levels, is at a lower concen-tration in depressive patients relative to healthy controls (Eskandari et al 2007, Hoogendijk et al 2008, Jorde et al 2006, Schneider et al 2000. However some other studies do not support these finding (Herrán et al 2000, Pan et al 2009).…”

Vitamin D status and its association with depression in US women; results from the National Health and Nutrition Examination Survey (NHANES) 2005–6

“…Some studies already suggest a relationship between poor mood elevation and low vitamin D status (2)(3)(4) and there is supporting evidence from the sunlight-related depressive disorder seasonal depressive disorder, which is negatively associated with serum 25-hydroxycholecalciferol (5) . Depression is predicted to become one of the leading causes of disability in the world (6) and thus poses a great public-heath burden and investigating the potential use of cost-effective measures such as increased sunlight exposure to alleviate this condition may reap benefit not only to the individual but also to the healthcare economy as well.…”