Low Body Mass Index for Early Screening of Adolescent Idiopathic Scoliosis: A Comparison Based on Standardized Body Mass Index Classifications

Kim, Suhee; Uhm, Ju-Yeon; Chae, Duckhee; Park, Yunhee

doi:10.1016/j.anr.2019.12.003

Cited by 14 publications

(17 citation statements)

References 44 publications

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“…Various possible risk factors related to the onset of scoliosis have been studied in the literature, such as growth alterations, postural disorders, heavy backpacks, environmental factors, high-risk sports and visual and dental disorders [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Risk Factors, Lifestyle and Prevention among Adolescents with Idiopathic Juvenile Scoliosis: A Cross Sectional Study in Eleven First-Grade Secondary Schools of Palermo Province, Italy

Scaturro

Costantino

Terrana

et al. 2021

IJERPH

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Adolescent idiopathic scoliosis (AIS) has an incidence of 2–3% in the general population and a multifactorial etiology. The present study aims to analyze modifiable risk factors and their interactions in the development of AIS in order to increase knowledge about the disease and to prevent the evolution of AIS in young students with tailored public health strategies. A cross-sectional study was conducted over two consecutive school years among students attending 11 first-grade secondary schools in the province of Palermo, Italy. A self-administered questionnaire that investigated socio-demographical, physical and anamnestic characteristics and habits, focusing on possible risk factors associated with idiopathic scoliosis, was administered. In addition, a clinical evaluation was performed with Adams’ test and Bunnel’s inclinometer. Suspected AIS cases were associated with the practice of high-risk sports (p < 0.05), weekly physical activity lasting ≥3 h (p < 0.05), lower back pain (p < 0.001), posture disorders (p < 0.01) and having had no contact with a physician (p < 0.01). Practice of high-risk sports (adj OR = 1.83; CI 95% 1.11–4.76) and suffering of posture disorders (adj OR = 1.67; CI 95% 1.12–3.60) showed a significant association with a confirmed diagnosis of AIS (Cobb angle ≥ 10° at X-ray). The risk factors associated with AIS are still unclear. Therefore, it is crucial to identify early modifiable and multiple risk factors to prevent the evolution of scoliosis in school-age children.

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Section: Introductionmentioning

confidence: 99%

Risk Factors, Lifestyle and Prevention among Adolescents with Idiopathic Juvenile Scoliosis: A Cross Sectional Study in Eleven First-Grade Secondary Schools of Palermo Province, Italy

Scaturro

Costantino

Terrana

et al. 2021

IJERPH

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“…Lower BMI prevails among AIS patients and has been reported previously [43]. Researches have reported the following possible reasons for lower BMI including leptin dysfunction, psychological factors [44 , 45]. However, the relationship between BMI and AIS is complex and the relevance of this relationship in terms of the pathogenesis of AIS remains unknown.…”

Section: Discussionmentioning

confidence: 87%

Plasma proteomics analysis of adolescent idiopathic scoliosis patients revealed by Quadrupole‐Orbitrap mass spectrometry

Wang

Liu

et al. 2021

Proteomics Clinical Apps

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We aim to investigate the changes of plasma proteome among mild, severe adolescent idiopathic scoliosis (AIS) patients and healthy controls. Methods: In this retrospective study, there were 84 individuals including 56 confirmed AIS patients (27 follow-up AIS patients and 29 surgical AIS patients) and another 28 healthy teenagers. Plasma samples were obtained and Quadrupole-Orbitrap Mass Spectrometer was performed to identify proteins in AIS patients and control group. T-test and ANOVA were performed to screen for differential proteins. GO and KEGG pathway, Pearson's correlation analysis and PLS model were applied to identify enriched proteins, investigate correlation between proteins and Cobb angles. ELISA was performed to further verify the quantitative proteomics results. Results: A total of 349 proteins were identified, among which 55 protein levels changed significantly in AIS group, compared with control group. Post hoc test indicated 36 proteins were significantly different between surgical and control group, 35 proteins between follow-up and control group. Fibronectin, fibrinogen and calmodulin were statistically different among three groups through mass spectrometry and were positively correlated with the Cobb angle. Conclusions:We performed the proteomic study and revealed that fibronectin, fibrinogen and calmodulin might not only be considered as biomarkers for AIS but could be correlated with curve severity.

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“…Low BMI is not only related to treatment and intervention, but also to scoliosis prevalence. KIM reported that the prevalence of thin students with scoliosis could increase by up to four times depending on the BMI criteria [29]. Jeon reported that low weight and the risk of developing scoliosis are very closely associated [30].…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of Scoliosis Screening Positive and its Influencing Factors: A School based Cross-sectional Study in Zhejiang Province, China

Zou

Lin

Meng

et al. 2021

Preprint

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Background: Early detection of scoliosis is of great significance to patients with scoliosis and the whole society. This paper aims to learn the prevalence of scoliosis screening positive among students in primary and secondary schools, and to explore the influencing factors. Methods: In 2019, a stratified cluster sampling technique was employed in this school based cross-sectional study. Sampling covers all prefecture level cities in Zhejiang Province. Based on the whole class, at least 80 students in each grade of primary school, junior high school and senior high school were selected. Physical examination and scoliosis screening were performed in the school-based investigation. Distribution of demographic characteristics and nutritional status of children and adolescents with scoliosis screening positive were explored. Results: A total of 45547 students were screened. The overall prevalence of children and adolescents with scoliosis screening positive were 3.9%. Higher prevalence of scoliosis screening positive was found in students living in urban area (4.1%), female students (4.1%), students with low weight (5.3%) (p < 0.05), and the prevalence increased with age (p < 0.05). In logistic analysis, we found age (OR=1.145), gender (OR=1.118) and low weight (OR=1.480) were the influencing factors for prevalence of scoliosis screening positive (p < 0.05). Conclusions: There were no disparities between living areas, but there was significant difference between genders, among different ages, and among different nutritional status of children and adolescents with or without scoliosis screening positive. In multi analysis, age, gender, and low weight were the influencing factors for prevalence of scoliosis screening positive. Age and gender specific scoliosis screening strategy and nutritional public health policies for children and adolescent are need.

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Low Body Mass Index for Early Screening of Adolescent Idiopathic Scoliosis: A Comparison Based on Standardized Body Mass Index Classifications

Cited by 14 publications

References 44 publications

Risk Factors, Lifestyle and Prevention among Adolescents with Idiopathic Juvenile Scoliosis: A Cross Sectional Study in Eleven First-Grade Secondary Schools of Palermo Province, Italy

Risk Factors, Lifestyle and Prevention among Adolescents with Idiopathic Juvenile Scoliosis: A Cross Sectional Study in Eleven First-Grade Secondary Schools of Palermo Province, Italy

Plasma proteomics analysis of adolescent idiopathic scoliosis patients revealed by Quadrupole‐Orbitrap mass spectrometry

The Prevalence of Scoliosis Screening Positive and its Influencing Factors: A School based Cross-sectional Study in Zhejiang Province, China

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