Low blood levels of lead and mercury and symptoms of attention deficit hyperactivity in children: A report of the children's health and environment research (CHEER)

Ha, Mina; Kwon, Ho Jang; Lim, Myung Ho; Jee, Young Koo; Hong, Yun Chul; Leem, Jong Han; Sakong, June; Bae, Jong-Myon; Hong, Soo Jong; Roh, Yun Ho; Jo, Seong Joon

doi:10.1016/j.neuro.2008.11.011

Cited by 118 publications

(92 citation statements)

References 22 publications

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“…24 Conversely, Nicolescu et al [41] did not find a signifi cant association between concurrent mercury levels and ADHD symptom scores in a cross-sectional study of Romanian children. The findings are in agreement with the study of bigger sample sizes that did not find a signifi cant relationship between mercury exposure and ADHDrelated outcomes [42].…”

Section: Criteria Of the Selection Of Studies To The Reviewsupporting

confidence: 92%

“…The later analysis conducted as part of the same survey (on 2588 children at 8-15 years of age) indicated that children who were exposed to prenatal tobacco and lead had greater risk of ADHD than it would be expected if the indepen dent risk was multiplied (OR = 8.1; 95% CI: 3.5-18.7; to bacco -lead exposure interaction p < 0.001) [51]. Additionally, studies conducted in South Korea [42], Chi na [52], India [53], and the US [54,55] also suggest a link between the blood lead level and the diagnosis or symp toms of ADHD. Four studies investigating the link be tween lead exposure and ADHD and/or ADHD-related symptoms were published in 2010 [41,[56][57][58].…”

Section: Summary Of the Study Resultsmentioning

confidence: 98%

“…For practical reasons, in some studies, maternal education/IQ and psychopathology are taken as proxy for the parental one. In addition to the heritability factors, the reported environmental risk factors for ADHD include: pregnancy and delivery complications, low birth weight, maternal smoking, and illicit drug and alcohol intake during preg nancy [42]. Furthermore, the quality of home environment (e.g.…”

Section: Summary Of the Study Resultsmentioning

confidence: 99%

“…Ha [42] and Nicolescu [42] did not find a significant relationship between mercury exposure and ADHD, whereas Cheuk [37] found higher risk of ADHD among children with exposure to mercury. Some studies suggest a link between exposure to mercury and ADHD behaviors: increased hyperactivity scores [45], sustained attention [44] and deficits in finger tapping speed and reaction time [43], but as the number of studies is rather limited, the observations need to be confirmed in other epidemiological studies.…”

Section: Criteria Of the Selection Of Studies To The Reviewmentioning

confidence: 89%

“…Mercury causes oxidative stress, lipid peroxidation, and mitochondrial dysfunction and disrupts synaptic transmission, microtubule formation, amino acid transport, and cellular migration in the devel oping brain [40], which can be associated with neurodevel opmental problems in children. Studies, which investigated the possible link between ex posure to mercury and ADHD or ADHD-related behaviors, were performed in China [37], Romania [41], South Korea [42], Faroe Islands [43,44], and in the Republic of Seychelles [45] (Table 3).…”

Section: Mercury and Adhd Or Adhd-related Symptomsmentioning

confidence: 99%

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Review of current evidence on the impact of pesticides, polychlorinated biphenyls and selected metals on attention deficit / hyperactivity disorder in children

Polańska¹,

Jurewicz²,

Hanke³

2013

International Journal of Occupational Medicine and Environmental Health

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The aim of this review was to investigate the association between attention deficit / hyperactivity disorder (ADHD) or AD HD-related symptoms and industrial chemicals, such as organophosphates and organochlorine pesticides, polychlorinated biphenyls (PCBs), lead, mercury and manganese. Medline, PubMed and EBSCO searches were performed to identify the studies that analyzed the association of prenatal and postnatal child exposure to such toxicants and ADHD or ADHD-re lated symptoms. The review is restricted to human studies published in English in peer-reviewed journals since 2000. Most of the presented studies focused on pesticides, PCB and lead. The impact of mercury and manganese was investigated less frequently. The findings indicate that children's exposure to organophosphate pesticides may cause symptoms consistent with pervasive developmental disorder, ADHD or attention problems. Exposures to organochlorine pesticides and PCBs were associated with ADHD-like behaviors such as alertness, quality of alert response, and cost of attention. The studies provided evidence that blood lead level below 10 μg/dl was associated with ADHD or ADHD-related symptoms. Informa tion on the association between exposure to mercury and neurotoxicity is limited, and requires further confirmation in future research. Two studies indicated that exposure to manganese is related to ADHD; such exposure and its impact on children neurodevelopment need to be further investigated. Future studies should use a prospective design with multiple biological samples collected over time for better assessment of exposure and its critical windows. Additionally, inclusion of potential confounding factors and co-exposures is crucial.

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Section: Criteria Of the Selection Of Studies To The Reviewsupporting

confidence: 92%

Section: Summary Of the Study Resultsmentioning

confidence: 98%

Section: Summary Of the Study Resultsmentioning

confidence: 99%

Section: Criteria Of the Selection Of Studies To The Reviewmentioning

confidence: 89%

Section: Mercury and Adhd Or Adhd-related Symptomsmentioning

confidence: 99%

See 3 more Smart Citations

Review of current evidence on the impact of pesticides, polychlorinated biphenyls and selected metals on attention deficit / hyperactivity disorder in children

Polańska¹,

Jurewicz²,

Hanke³

2013

International Journal of Occupational Medicine and Environmental Health

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Prenatal Exposure to Mercury and Fish Consumption During Pregnancy and Attention-Deficit/Hyperactivity Disorder–Related Behavior in Children

Sagiv¹,

Thurston²,

Bellinger³

et al. 2012

Arch Pediatr Adolesc Med

159

105

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In situ electrical stimulation for enhanced bone growth: A mini‐review

2020

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The role of electrical stimuli in directing cellular activities during natural tissue healing and regeneration process has been well recognized. This observation has prompted the development and use of exogenous electrical stimulations in the treatment of delayed unions and non‐unions of bone fracture in different parts of the human skeletal system. Considerable amount of clinical evidences has also been generated on the benefits of exogenous bone growth stimulators. However, the clinical efficacy and safety of these exogenous electrical stimulating methods are being argued to be inconsistent and inconclusive, due to lack of sufficient number of well‐controlled, randomized clinical studies. As a result, there has been significant interest in the development of smart biomaterials, which can generate in situ electrical stimuli, for accelerated bone repair, healing and regeneration. These smart biomaterials are essentially either composite biomaterials containing electrically active materials or biomaterials that can be polarized. The primary objective of this mini review was to provide an overview of different exogenous electrical stimulation methods and biocomposites for in situ stimulation, which can be used for bone growth and healing. The first part is focused on exogenous stimulation methods, and the second part discusses the use of biocomposites containing electrically active materials such as piezoelectric materials and multiferroic materials for accelerated repair and regeneration of bone.

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Low blood levels of lead and mercury and symptoms of attention deficit hyperactivity in children: A report of the children's health and environment research (CHEER)

Cited by 118 publications

References 22 publications

Review of current evidence on the impact of pesticides, polychlorinated biphenyls and selected metals on attention deficit / hyperactivity disorder in children

Review of current evidence on the impact of pesticides, polychlorinated biphenyls and selected metals on attention deficit / hyperactivity disorder in children

Prenatal Exposure to Mercury and Fish Consumption During Pregnancy and Attention-Deficit/Hyperactivity Disorder–Related Behavior in Children

In situ electrical stimulation for enhanced bone growth: A mini‐review

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