Low Birth Weight and Lung Function in Adulthood: Retrospective Cohort Study in China, 1948–1996

Pei, Lijun; Chen, Gong; Mi, Jie; Zhang, Ting; Song, Xiaomin; Chen, Jiapeng; Ji, Ying; Li, Cheng-Fu; Zheng, Xiaoying

doi:10.1542/peds.2008-3086

Cited by 40 publications

(33 citation statements)

References 30 publications

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“…Our results are consistent with previous studies that suggested that children with histories of not only LBW and pre-term birth, but also SGA, a synthetic indicator of birthweight and gestational age, had increased risks of allergic respiratory symptoms [13][14][15][16][17][18]32]. Impaired growth in utero, resulting in LBW and earlier gestational age, is associated with diminished surfactant activity and pulmonary cellularity, due to the fact that the lungs of immature neonates are not fully developed either anatomically or immunologically [13,[16][17][18].…”

Section: Discussionsupporting

confidence: 92%

Joint effects of birth outcomes and childhood body mass index on respiratory symptoms

Wang

Chen²,

Hsieh³

et al. 2012

Eur Respir J

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Thinness in infancy and higher childhood body mass index (BMI) are risk factors for poor respiratory health. However, few studies have examined the joint effects of birth outcomes and childhood BMI on the occurrence of respiratory symptoms.A total of 78,011 Taiwanese middle-school children were investigated between 1995 and 1996 in a nationwide International Study of Asthma and Allergies in Childhood (ISAAC) survey, with standardised height/weight measurement. Their survey data was compared successfully with the birth registration dataset.Childhood BMI was positively associated with all respiratory symptoms, with greater effects and significant risks associated with serious phenotypes in the video questionnaire. Children with a history of low birth weight (LBW), those who were born prematurely (pre-term), or those who were small for gestational age (SGA) were also more likely to have allergic respiratory symptoms. As birthweight and gestational age were not positively associated with childhood BMI, we proposed that LBW, pre-term birth and childhood BMI were independent factors for respiratory symptoms.LBW, pre-term birth and childhood BMI are all independent risk factors for respiratory symptoms in children. Children with a history of LBW, pre-term birth or SGA and a higher current BMI might have larger respiratory burden.

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Section: Discussionsupporting

confidence: 92%

Joint effects of birth outcomes and childhood body mass index on respiratory symptoms

Wang

Chen²,

Hsieh³

et al. 2012

Eur Respir J

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“…These studies suggest that the high mortality from COPD in low-income countries is associated with a low FVC and not obstruction, as has generally been assumed, and raises an important question over the origins of this low FVC. There is good evidence that low ventilatory function in later life is associated with low birthweight [5,[24][25][26][27] and possibly with early infections [4,5,28], and these conditions are associated with poverty [4,29,30]. However, COPD mortality appears to respond immediately to improvements in GNI, and it is therefore unlikely that the changes noted here are solely related to effects from poverty in early life.…”

Section: Discussionmentioning

confidence: 75%

Global and regional trends in COPD mortality, 1990–2010

et al. 2015

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Between 1990 and 2010, chronic obstructive pulmonary disease (COPD) moved from the fourth to third most common cause of death worldwide.Using data from the Global Burden of Disease programme we quantified regional changes in the number of COPD deaths and COPD mortality rates between 1990 and 2010. We estimated the proportion of the change that was attributable to gross national income per capita and an index of cumulative smoking exposure, and quantified the difference in mortality rates attributable to demographic changes.Despite a substantial decrease in COPD mortality rates, COPD deaths fell only slightly, from three million in 1990 to 2.8 million in 2010, because the mean age of the population increased. The number of COPD deaths in 2010 would have risen to 5.2 million if the age-and sex-specific mortality rates had remained constant. Changes in smoking led to only a small increase in age-and sex-specific mortality rates, which were strongly associated with changes in gross national income.The increased burden of COPD mortality was mainly driven by changes in age distribution, but ageand sex-specific rates fell as incomes rose. The rapid response to increasing affluence suggests that changes in COPD mortality are not entirely explained by changes in early life. @ERSpublications COPD age-standardised mortality rates decrease as incomes increase, but COPD deaths increase as population ages

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“…All studies adjusted for age, sex and height, except for two that did not adjust for height. In particular, one study (24) did not adjust the association of FVC for height. Tables E8 and E9 show the effect estimates for FVC and FEV1/FVC, respectively, used in the sensitivity analyses that included adjustment for smoking.…”

Section: Characteristics Of the Studies Includedmentioning

confidence: 99%

Birth Weight and Lung Function in Adulthood: A Systematic Review and Meta-analysis

et al. 2017

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At a Glance CommentaryScientific knowledge on the subject: Increasing evidence supports the influence of early life factors on later lung function, which might prevent individuals from attaining maximum lung function and predispose them to increased risk of lung disease in later life.What this study adds to the field: This is the first systematic review and meta-analysis on the association of birth weight, weight at one year and weight gain in the first year of life with lung function measures of both restrictive and obstructive patterns in adulthood. We convincingly show a positive association between birth weight and restrictive impairment (low FVC), with findings consistent across studies. The meta-analysis for birth weight and airflow obstruction (low FEV1/FVC) might suggest a positive association but the evidence is much weaker. We identified gaps and limitations in the current evidence that should be addressed in future research.This article has an online data supplement, which is accessible from this issue's table of content online at www.atsjournals.org. 3 AbstractRationale: There is evidence suggesting that birth weight may influence lung function in adulthood, but it is unclear whether it might differentially affect restrictive (FVC) and obstructive (FEV1/FVC) patterns.Objectives: To summarize evidence available on the association of birth weight, weight at one year and weight gain in the first year of life with FVC and FEV1/FVC in adulthood. Methods:We performed a systematic review of the literature by searching MEDLINE, EMBASE and Web of Science through January 2015. Data were combined using inversevariance weighted meta-analysis with random effects models, and between-study heterogeneity evaluated. We conducted a priori subgroup or sensitivity analyses by age, country wealth, ethnicity, sex and smoking. Risk of bias was evaluated using the Newcastle-Ottawa Scale, and reporting bias using funnel plots. Measurements and Main Results:Eighteen articles were included in the review, and 13 in the meta-analyses. Most studies were from high-income countries, and all showed low risk of bias.We found strong evidence of association of birth weight with adult FVC, a 59.4mL higher FVC in adulthood per kg increase in birth weight (95%CI: 43.3 to 75.5), with no evidence of heterogeneity. Evidence of an association of birth weight with FEV1/FVC was weaker and showed some inconsistency across studies. Only one study investigated weight at one year, and another one weight gain in the first year. Conclusions:Our meta-analyses show strong and consistent evidence of an association of birth weight with adult FVC, a measure of restrictive impairment, with much weaker evidence for airflow obstruction.

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Low Birth Weight and Lung Function in Adulthood: Retrospective Cohort Study in China, 1948–1996

Abstract: Low birth weight may increase the prevalence of and risk for low lung function in adulthood in the Chinese population. The development of lung function may be affected by hypogenesis in utero.

Cited by 40 publications

References 30 publications

Joint effects of birth outcomes and childhood body mass index on respiratory symptoms

Joint effects of birth outcomes and childhood body mass index on respiratory symptoms

Global and regional trends in COPD mortality, 1990–2010

Birth Weight and Lung Function in Adulthood: A Systematic Review and Meta-analysis

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