Low‐beta repetitive transcranial magnetic stimulation to human dorsolateral prefrontal cortex during object recognition memory sample presentation, at a task‐related frequency observed in local field potentials in homologous macaque cortex, impairs subsequent recollection but not familiarity

Abstract

According to dual-process signal-detection (DPSD) theories, short-and longterm recognition memory draws upon both familiarity and recollection. It remains unclear how primate prefrontal cortex (PFC) contributes to these processes, but frequency-specific neuronal activities are considered to play a key role. In Experiment 1, nonhuman primate (NHP) local field potential (LFP) electrophysiological recordings in macaque left dorsolateral PFC (dlPFC) rev-

Tracking subjects’ strategies in behavioural choice experiments at trial resolution

“…Most of their daily food ration of wet mash and fruit and nuts and other treats were delivered in the automated testing/lunch-box at the end of each behavioral session (this provided ‘jack-pot’ motivation for quickly completing successful session performance; supplemented by the trial-by-trial rewards for correct choices in the form of drops of smoothie delivered via a sipping tube) and this was supplemented with fruit and foraging mix in the home enclosure. For the study the animal was prepared for parallel neurophysiological investigation, and so was head-fixated during the task using a standard titanium head-post (and also had recording implants); implantation adopted standard aseptic surgical methods used in the non-human primate laboratory that are not directly relevant for this behavioural study but are described in detail elsewhere ( Wu et al, 2021 ). All animal training and experimental procedures were performed in accordance with the guidelines of the UK Animals (Scientific Procedures) Act of 1986, licensed by the UK Home Office, and approved by Oxford’s Committee on Animal Care and Ethical Review.…”