Low and moderate doses of acute ethanol do not impair spatial cognition but facilitate accelerating rotarod performance in adolescent and adult rats

Novier, Adelle; Skike, Candice E. Van; Chin, Vivien S.; Diaz-Granados, Jaime L.; Matthews, Douglas B.

doi:10.1016/j.neulet.2012.01.059

Cited by 13 publications

(9 citation statements)

References 46 publications

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“…These findings are also generally consistent with human literature in which college aged humans (post-adolescent) were more susceptible to the memory impairing effect of ethanol than were middle-aged adults [28]. Despite these findings, the adolescent sensitivity to the memory impairing effects of ethanol have not been observed consistently across cognitive end points in the Morris water maze [29,30]; in alternate measures of spatial learning [31]; or across species [32]. …”

Section: Introductionsupporting

confidence: 87%

Effects of Acute or Chronic Ethanol Exposure during Adolescence on Behavioral Inhibition and Efficiency in a Modified Water Maze Task

et al. 2013

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Ethanol is well known to adversely affect frontal executive functioning, which continues to develop throughout adolescence and into young adulthood. This is also a developmental window in which ethanol is misused by a significant number of adolescents. We examined the effects of acute and chronic ethanol exposure during adolescence on behavioral inhibition and efficiency using a modified water maze task. During acquisition, rats were trained to find a stable visible platform onto which they could escape. During the test phase, the stable platform was converted to a visible floating platform (providing no escape) and a new hidden platform was added in the opposite quadrant. The hidden platform was the only means of escape during the test phase. In experiment 1, adolescent animals received ethanol (1.0g/kg) 30min before each session during the test phase. In experiment 2, adolescent animals received chronic intermittent ethanol (5.0g/kg) for 16 days (PND30 To PND46) prior to any training in the maze. At PND72, training was initiated in the same modified water maze task. Results from experiment 1 indicated that acute ethanol promoted behavioral disinhibition and inefficiency. Experiment 2 showed that chronic intermittent ethanol during adolescence appeared to have no lasting effect on behavioral disinhibition or new spatial learning during adulthood. However, chronic ethanol did promote behavioral inefficiency. In summary, results indicate that ethanol-induced promotion of perseverative behavior may contribute to the many adverse behavioral sequelae of alcohol intoxication in adolescents and young adults. Moreover, the long-term effect of adolescent chronic ethanol exposure on behavioral efficiency is similar to that observed after chronic exposure in humans.

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Section: Introductionsupporting

confidence: 87%

Effects of Acute or Chronic Ethanol Exposure during Adolescence on Behavioral Inhibition and Efficiency in a Modified Water Maze Task

et al. 2013

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“…However, Novier et al (2012) found that adolescent and adult animals had facilitated RR performance following administration of a low (1.0 g/kg) dose of alcohol, a result that is replicated for adult animals but not adolescent animals in the current work. Furthermore, the current work is the first to investigate both low (1.0 g/kg) and moderately high (2.0 g/kg) doses of ethanol on the rotarod across a full age range.…”

Section: Discussionsupporting

confidence: 61%

“…Animals were individually housed and given ad libitum access to food and water M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 7 throughout the experiment. Following previously published methods, all rats acclimated to the colony room for 2 days before any experimental procedures (Chin et al, 2011;Novier, Van Skike, Chin, Diaz-Granados, & Matthews, 2012;Novier et al, 2013;Silvers et al, 2006;.…”

Section: Subjectsmentioning

confidence: 99%

The effects of acute alcohol on motor impairments in adolescent, adult, and aged rats

Ornelas

Novier

Skike

et al. 2015

Alcohol

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“…Acute exposure of hippocampal slices to EtOH suppressed the induction of LTP and NMDA receptor-mediated synaptic activity, and enhanced extrasynaptic GABA A receptor function more potently in slices from adolescent rats than in those from adults [24]–[27]. These findings notwithstanding, the neurodevelopmental sensitivity to ethanol on measures of learning and memory has not been observed consistently across species or memory tasks [28]–[31].…”

Section: Introductionmentioning

confidence: 85%

Long-Term Effects of Chronic Intermittent Ethanol Exposure in Adolescent and Adult Rats: Radial-Arm Maze Performance and Operant Food Reinforced Responding

et al. 2013

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BackgroundAdolescence is not only a critical period of late-stage neurological development in humans, but is also a period in which ethanol consumption is often at its highest. Given the prevalence of ethanol use during this vulnerable developmental period we assessed the long-term effects of chronic intermittent ethanol (CIE) exposure during adolescence, compared to adulthood, on performance in the radial-arm maze (RAM) and operant food-reinforced responding in male rats.Methodology/Principal FindingsMale Sprague Dawley rats were exposed to CIE (or saline) and then allowed to recover. Animals were then trained in either the RAM task or an operant task using fixed- and progressive- ratio schedules. After baseline testing was completed all animals received an acute ethanol challenge while blood ethanol levels (BECs) were monitored in a subset of animals. CIE exposure during adolescence, but not adulthood decreased the amount of time that animals spent in the open portions of the RAM arms (reminiscent of deficits in risk-reward integration) and rendered animals more susceptible to the acute effects of an ethanol challenge on working memory tasks. The operant food reinforced task showed that these effects were not due to altered food motivation or to differential sensitivity to the nonspecific performance-disrupting effects of ethanol. However, CIE pre-treated animals had lower BEC levels than controls during the acute ethanol challenges indicating persistent pharmacokinetic tolerance to ethanol after the CIE treatment. There was little evidence of enduring effects of CIE alone on traditional measures of spatial and working memory.Conclusions/SignificanceThese effects indicate that adolescence is a time of selective vulnerability to the long-term effects of repeated ethanol exposure on neurobehavioral function and acute ethanol sensitivity. The positive and negative findings reported here help to further define the nature and extent of the impairments observed after adolescent CIE and provide direction for future research.

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Low and moderate doses of acute ethanol do not impair spatial cognition but facilitate accelerating rotarod performance in adolescent and adult rats

Cited by 13 publications

References 46 publications

Effects of Acute or Chronic Ethanol Exposure during Adolescence on Behavioral Inhibition and Efficiency in a Modified Water Maze Task

Effects of Acute or Chronic Ethanol Exposure during Adolescence on Behavioral Inhibition and Efficiency in a Modified Water Maze Task

The effects of acute alcohol on motor impairments in adolescent, adult, and aged rats

Long-Term Effects of Chronic Intermittent Ethanol Exposure in Adolescent and Adult Rats: Radial-Arm Maze Performance and Operant Food Reinforced Responding

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