Loss of Regulation of Lipid Metabolism in Morris Hepatomas: A Potential Role for Cytoplasmic Binding Proteins

Mishkin, Seymour; Halperin, Mitchell L.

doi:10.1007/978-1-4615-8852-8_23

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Fabp and Pathology1

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2009

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Cited by 10 publications

(1 citation statement)

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“…FABP content and intracellular fatty acid metabolism may be closely related. In Morris hepatoma a nutritional regulation of fatty acid synthesis was absent, together with a decrease of the FABP content to 20% of that in liver [254]. The FABP level appears to be associated with normal mitosis and carcinogen-induced pro liferation of hepatocytes [219].…”

Section: Fabp and Pathologymentioning

confidence: 99%

Fatty acid-binding proteins

徳田¹,

安達²,

澤田³

2009

British Journal of Pharmacology

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Section: Fabp and Pathologymentioning

confidence: 99%

Fatty acid-binding proteins

徳田¹,

安達²,

澤田³

2009

British Journal of Pharmacology

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Intracellular Fatty-Acid-Binding Proteins Characteristics and Function

Paulussen

Veerkamp

1990

Subcellular Biochemistry

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Uptake and metabolism of free fatty acids by the morris 7777 hepatoma and host rat liver

Morton

Waite

King

et al. 1982

Lipids

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The relative capacity of Morris 7777 hepatomas and livers of tumor-bearing rats to take up and subsequently metabolize intravenously injected radiolabeled free fatty acids was investigated. The objective was to determine differences in lipid metabolism which may affect the lipid composition previously observed in this tumor. Both tissues demonstrated comparable selectivity in the uptake of palmitate, linoleate and arachidonate from blood, although the hepatoma took up one-tenth as much free fatty acid per g wet wt as liver. A much greater percentage of fatty acid taken up by the hepatoma was converted to aqueous soluble radioactivity, perhaps the result of oxidation. In the hepatoma, palmitate was incorporated into phospholipid molecular species in a pattern similar to that observed for diglyceride, which suggested that phospholipid synthesis occurred predominantly de novo. On the other hand, in liver, a large percentage of palmitate was incorporated into polyunsaturated phospholipid molecular species that were not present in the diglyceride pool, which suggested significant incorporation by the acylation of monoacyl phosphoglycerides. These studies indicate that the specificity for the uptake of fatty acids was not different in the two tissues; however, the subsequent metabolic processes are markedly different.

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Loss of Regulation of Lipid Metabolism in Morris Hepatomas: A Potential Role for Cytoplasmic Binding Proteins

Cited by 10 publications

References 48 publications

Fatty acid-binding proteins

Fatty acid-binding proteins

Intracellular Fatty-Acid-Binding Proteins Characteristics and Function

Uptake and metabolism of free fatty acids by the morris 7777 hepatoma and host rat liver

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