Loss of polarity protein Par3 in the intestinal epithelium promotes colitis‐associated colorectal cancer progression by damaging tight junction assembly

Luo, Binbin; Song, Linyi; Chen, Limiao; Cai, Yue; Zhang, Mingwei; Wang, Shenyi

doi:10.1002/mc.23630

Cited by 2 publications

(1 citation statement)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its deficiency allows penetration of pathogenic bacteria and endotoxins into the intestinal submucosa, activating the TLR4/MyD88/NF-κB signaling pathway. This activation promotes inflammation-driven CRC development, suggesting Par3 as a potential molecular marker for early-stage CRC diagnosis [ 74 ]. TLRs, essential recognition receptors for innate immune cells, activate inflammatory processes.…”

Section: Tlr4 Pathway-related Biochemical Processesmentioning

confidence: 99%

The Role of Natural Products from Herbal Medicine in TLR4 Signaling for Colorectal Cancer Treatment

Luo,

Zhang,

et al. 2024

Molecules

View full text Add to dashboard Cite

The toll-like receptor 4 (TLR4) signaling pathway constitutes an intricate network of protein interactions primarily involved in inflammation and cancer. This pathway triggers intracellular signaling cascades, modulating transcription factors that regulate gene expression related to immunity and malignancy. Previous studies showed that colon cancer patients with low TLR4 expression exhibit extended survival times and the TLR4 signaling pathway holds a significant role in CRC pathogenesis. In recent years, traditional Chinese medicines (TCMs) have garnered substantial attention as an alternative therapeutic modality for CRC, primarily due to their multifaceted composition and ability to target multiple pathways. Emerging evidence indicates that specific TCM products, such as andrographolide, rosmarinic acid, baicalin, etc., have the potential to impede CRC development through the TLR4 signaling pathway. Here, we review the role and biochemical processes of the TLR4 signaling pathway in CRC, and natural products from TCMs affecting the TLR4 pathway. This review sheds light on potential treatment strategies utilizing natural TLR4 inhibitors for CRC, which contributes to the advancement of research and accelerates their clinical integration into CRC treatment.

show abstract

Section: Tlr4 Pathway-related Biochemical Processesmentioning

confidence: 99%

The Role of Natural Products from Herbal Medicine in TLR4 Signaling for Colorectal Cancer Treatment

Luo,

Zhang,

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

Research status and hotspots of tight junctions and colorectal cancer: A bibliometric and visualization analysis

Li,

Liu,

Hao

et al. 2024

World J Gastrointest Oncol

View full text Add to dashboard Cite

BACKGROUND Colorectal cancer (CRC) is the third most common cancer worldwide and the second leading cause of cancer-related death. Over the past two decades, numerous researchers have provided important evidence regarding the role of tight junction (TJ) proteins in the occurrence and progression of CRC. The causal relationship between the presence of specific TJ proteins and the development of CRC has also been confirmed. Despite the large number of publications in this field, a bibliometric study to review the current state of research and highlight the research trends and hotspots in this field has not yet been performed. AIM To analyze research on TJs and CRC, summarize the field’s history and current status, and predict future research directions. METHODS We searched the Science Citation Index Expanded database for all literature on CRC and TJs from 2001-2023. We used bibliometrics to analyze the data of these papers, such as the authors, countries, institutions, and references. Co-authorship, co-citation, and co-occurrence analyses were the main methods of analysis. CiteSpace and VOSviewer were used to visualize the results. RESULTS A total of 205 studies were ultimately identified. The number of publications on this topic has steadily increased since 2007. China and the United States have made the largest contributions to this field. Anticancer Research was the most prolific journal, publishing 8 articles, while the journal Oncogene had the highest average citation rate (68.33). Professor Dhawan P was the most prolific and cited author in this field. Co-occurrence analysis of keywords revealed that “tight junction protein expression”, “colorectal cancer”, “intestinal microbiota”, and “inflammatory bowel disease” had the highest frequency of occurrence, revealing the research hotspots and trends in this field. CONCLUSION This bibliometric analysis evaluated the scope and trends of TJ proteins in CRC, providing valuable research perspectives and future directions for studying the connection between the two. It is recommended to focus on emerging research hotspots, such as the correlations among intestinal microbiota, inflammatory bowel disease, TJ protein expression, and CRC.

show abstract

Loss of polarity protein Par3 in the intestinal epithelium promotes colitis‐associated colorectal cancer progression by damaging tight junction assembly

Cited by 2 publications

References 38 publications

The Role of Natural Products from Herbal Medicine in TLR4 Signaling for Colorectal Cancer Treatment

The Role of Natural Products from Herbal Medicine in TLR4 Signaling for Colorectal Cancer Treatment

Research status and hotspots of tight junctions and colorectal cancer: A bibliometric and visualization analysis

Contact Info

Product

Resources

About