Loss of phospholipase Cγ1 suppresses hepatocellular carcinogenesis through blockade of STAT3‐mediated cancer development

Seo, Eun‐Bi; Jang, Hyun‐Jun; Kwon, Sun-Ho; Kim, Seul‐Ki; Lee, Song‐Hee; Jeong, Ae Jin; Shin, Hyun Mu; Kim, Yong‐Nyun; Ma, Stephanie; Kim, Haeryoung; Lee, Yun‐Han; Suh, Pann‐Ghill; Ye, Sang‐Kyu

doi:10.1002/hep4.2077

Cited by 4 publications

(2 citation statements)

References 46 publications

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“…On the other hand, PLCG2 was an unexpected biomarker found in the present study and its function was unclear until now. Given that PLCG1 recently has been proven to be a pro‐tumorigenesis gene in HCC by Seo et al, the role of PLCG2 in the procession of hepatocellular carcinogenesis was worth to be explored in the future 36 …”

Section: Discussionmentioning

confidence: 99%

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Development and validation of robust metabolism‐related gene signature in the prognostic prediction of hepatocellular carcinoma

Pan

Zhang

Chen

et al. 2023

J Cellular Molecular Medi

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Hepatocellular carcinoma (HCC) is one of the most common malignant tumours worldwide. Given metabolic reprogramming in tumours was a crucial hallmark, several studies have demonstrated its value in the diagnostics and surveillance of malignant tumours. The present study aimed to identify a cluster of metabolism‐related genes to construct a prediction model for the prognosis of HCC. Multiple cohorts of HCC cases (466 cases) from public datasets were included in the present analysis. (GEO cohort) After identifying a list of metabolism‐related genes associated with prognosis, a risk score based on metabolism‐related genes was formulated via the LASSO‐Cox and LASSO‐pcvl algorithms. According to the risk score, patients were stratified into low‐ and high‐risk groups, and further analysis and validation were accordingly conducted. The results revealed that high‐risk patients had a significantly worse 5‐year overall survival (OS) than low‐risk patients in the GEO cohort. (30.0% vs. 57.8%; hazard ratio [HR], 0.411; 95% confidence interval [95% CI], 0.302–0.651; p < 0.001) This observation was confirmed in the external TCGA‐LIHC cohort. (34.5% vs. 54.4%; HR 0.452; 95% CI, 0.299–0.681; p < 0.001) To promote the predictive ability of the model, risk score, age, gender and tumour stage were integrated into a nomogram. According to the results of receiver operating characteristic curves and decision curves analysis, the nomogram score possessed a superior predictive ability than conventional factors, which indicate that the risk score combined with clinicopathological features was able to achieve a robust prediction for OS and improve the individualized clinical decision making of HCC patients. In conclusion, the metabolic genes related to OS were identified and developed a metabolism‐based predictive model for HCC. Through a series of bioinformatics and statistical analyses, the predictive ability of the model was approved.

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Section: Discussionmentioning

confidence: 99%

“…al., the role of PLCG2 in the procession of hepatocellular carcinogenesis was worth to be explored in the future 36. …”

mentioning

confidence: 99%

Development and validation of robust metabolism‐related gene signature in the prognostic prediction of hepatocellular carcinoma

Pan

Zhang

Chen

et al. 2023

J Cellular Molecular Medi

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Loss of phospholipase Cγ1 suppresses hepatocellular carcinogenesis through blockade of STAT3‐mediated cancer development

et al. 2022

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Phospholipase C gamma 1 (PLCγ1) plays an oncogenic role in several cancers, alongside its usual physiological roles. Despite studies aimed at identifying the effect of PLCγ1 on tumors, the pathogenic role of PLCγ1 in the tumorigenesis and development of hepatocellular carcinoma (HCC) remains unknown. To investigate the function of PLCγ1 in HCC, we generated hepatocyte-specific PLCγ1 conditional knockout (PLCγ1 f/f ; Alb-Cre) mice and induced HCC with diethylnitrosamine (DEN). Here, we identified that hepatocyte-specific PLCγ1 deletion effectively prevented DEN-induced HCC in mice. PLCγ1 f/f ; Alb-Cre mice showed reduced tumor burden and tumor progression, as well as a decreased incidence of HCC and less marked proliferative and inflammatory responses. We also showed that oncogenic phenotypes such as repressed apoptosis, and promoted proliferation, cell cycle progression and migration, were induced by PLCγ1. In terms of molecular mechanism, PLCγ1 regulated the activation of signal transducer and activator of transcription 3 (STAT3) signaling. Moreover,

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Role of phospholipases in hepatocellular carcinoma

Yassin,

Zaky,

Ahmed

2023

Phospholipases in Physiology and Pathology

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Loss of phospholipase Cγ1 suppresses hepatocellular carcinogenesis through blockade of STAT3‐mediated cancer development

Cited by 4 publications

References 46 publications

Development and validation of robust metabolism‐related gene signature in the prognostic prediction of hepatocellular carcinoma

Development and validation of robust metabolism‐related gene signature in the prognostic prediction of hepatocellular carcinoma

Loss of phospholipase Cγ1 suppresses hepatocellular carcinogenesis through blockade of STAT3‐mediated cancer development

Role of phospholipases in hepatocellular carcinoma

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