Loss of Matrix Calcium-Binding Protein-Containing Neurons in Huntington's Disease

Seto‐Ohshima, Akiko; Lawson, Eric M.; Emson, Piers C.; Mountjoy, C.Q.; Carrasco, L.H.

doi:10.1016/s0140-6736(88)92073-9

Cited by 131 publications

(64 citation statements)

References 24 publications

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“…The total area of the matrix compartment, as defined by calbindin and acetylcholinesterase activities, is decreased significantly in HD, whereas the total area of the patch compartments remains within normal limits (Ferrante et al, 1986(Ferrante et al, , 1987aKowall et al, 1987;Seto-Oshima et al, 1988). The range in diameter size of striosomes is approximately the same in HD and controls (Ferrante et al, 1987a).…”

Section: Discussionmentioning

confidence: 95%

“…Medium-sized spiny striatal neurons, and those neurochemical substances contained within them, are disproportionately affected early and most severely in HD (Marshall et al, 1983;Graveland et al, 1985;Ferrante et al, 1986Ferrante et al, , 1991Seto-Oshima et al, 1988;Goto et al, 1989), whereas large and medium-sized aspiny striatal neurons and their chemical components are relatively spared (Dawbarn et al, 1985;Ferrante et al, , 1987aAlbin et al, 1990).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies in HD suggest that there is greater pathological involvement within the striatal matrix zone than within the patch compartments (Ferrante et al, 1986(Ferrante et al, , 1987aKowall et al, 1987;Seto-Oshima et al, 1988;Richardson, 1990;Ferrante, 1991;Faull et al, 1993). The total area of the matrix compartment, as defined by calbindin and acetylcholinesterase activities, is decreased significantly in HD, whereas the total area of the patch compartments remains within normal limits (Ferrante et al, 1986(Ferrante et al, , 1987aKowall et al, 1987;Seto-Oshima et al, 1988).…”

Section: Discussionmentioning

confidence: 99%

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Heterogeneous Topographic and Cellular Distribution of Huntingtin Expression in the Normal Human Neostriatum

et al. 1997

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A striking heterogeneous distribution of topographic and cellular huntingtin immunoreactivity was observed within the human neostriatum using three distinct huntingtin antibodies. Patchy areas of low huntingtin immunoreactivity were present in both the caudate nucleus and putamen, surrounded by an intervening area of greater immunoreactivity. Comparison of huntingtin immunoreactivity with contiguous serial sections stained for enkephalin and calbindin D28k immunoreactivities showed that the topographic heterogeneity of huntingtin immunostaining corresponded to the patch (striosome) and matrix compartments within the striatum. Huntingtin immunoreactivity was confined primarily to neurons and neuropil within the matrix compartment, whereas little or no neuronal or neuropil huntingtin immunostaining was observed within the patch compartment. There was marked variability in the intensity of huntingtin immunolabel among medium-sized striatal neurons, whereas a majority of large striatal neurons were only faintly positive or without any immunoreactivity. Combined techniques for NADPH-diaphorase enzyme histochemistry and huntingtin immunocytochemistry, as well as double immunofluorescence for either nitric oxide synthase or calbindin D28k in comparison with huntingtin expression, revealed a striking correspondence between calbindin D28k and huntingtin immunoreactivities, with little or no colocalization between NADPH-diaphorase or nitric oxide synthase neurons and huntingtin expression. These observations suggest that the selective vulnerability of spiny striatal neurons and the matrix compartment observed in Huntington's disease is associated with higher levels of huntingtin expression, whereas the relative resistance of large and medium-sized aspiny neurons and the patch compartments to degeneration is associated with low levels of huntingtin expression.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Heterogeneous Topographic and Cellular Distribution of Huntingtin Expression in the Normal Human Neostriatum

et al. 1997

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“…The low GluR1-GluR4 levels characteristic of ChAT+, SS + and CALR+ interneurons and their sparse cortical input may explain their low vulnerability to excitotoxicity. Note that while CALB+ projection neurons, PARV+ interneurons, and CALR + interneurons are all defined by their enrichment in a particular calcium binding protein, possessing a calcium binding protein per se does not determine vulnerability in HD, since CALB+ projection neurons and PARV+ interneurons are vulnerable (Seto-Ohshima et al, 1988;Ferrer et al, 1994;Deng et al, 2004), and both the medium-sized CALR+ interneurons and the large cholinergic CALR+ interneurons are resistant (Cichetti et al, 1996(Cichetti et al, , 2000.…”

Section: Projection Neurons Versus Interneurons-thementioning

confidence: 99%

Differential localization of the GluR1 and GluR2 subunits of the AMPA-type glutamate receptor among striatal neuron types in rats

Deng

Xie

Wang

et al. 2007

Journal of Chemical Neuroanatomy

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Differences among the various striatal projection neuron and interneuron types in cortical input, function, and vulnerability to degenerative insults may be related to differences among them in AMPA-type glutamate receptor abundance and subunit configuration. We therefore used immunolabeling to assess the frequency and abundance of GluR1 and GluR2, the most common AMPA subunits in striatum, in the main striatal neuron types. All neurons projecting to the external pallidum (GPe), internal pallidum (GPi) or substantia nigra, as identified by retrograde labeling, possessed perikaryal GluR2, while GluR1 was more common in striato-GPe than striato-GPi perikarya. The frequency and intensity of immunostaining indicated the rank order of their perikaryal GluR1:GluR2 ratio to be striato-GPe > striatonigral > striato-GPi. Ultrastructural studies suggested a differential localization of GluR1 and GluR2 to striatal projection neuron dendritic spines as well, with GluR1 seemingly more common in striato-GPe spines and GluR2 more common in striato-GPi and/or striatonigral spines. Comparisons among projection neurons and interneurons revealed GluR1 to be most common and abundant in parvalbuminergic interneurons, and GluR2 most common and abundant in projection neurons, with the rank order for the GluR1:GluR2 ratio being parvalbuminergic interneurons > calretinergic interneurons > cholinergic interneurons > projection neurons > somatostatinergic interneurons. Striosomal projection neurons had a higher GluR1:GluR2 ratio than did matrix projection neurons. The abundance of both GluR1 and GluR2 in striatal parvalbuminergic interneurons and projection neurons is consistent with their prominent cortical input and susceptibility to excitotoxic insult, while differences in GluR1: GluR2 ratio among projection neurons are likely to yield differences in Ca2+ permeability, desensitization, and single channel current, which may contribute to differences among them in plasticity, synaptic integration, and excitotoxic vulnerability. The apparent association of the GluR1 subunit with synaptic plasticity, in particular, suggests striato-GPe neuron spines as a particular site of corticostriatal synaptic plasticity, presumably associated with motor learning.

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“…Seto-Ohshima, 2003 yılında Huntington hastalığından (HD) ölen kişilerin beyinlerinde yaptığı çalışmada neostriatum bölgesindeki kalbindin içeren nöronların önemli derece azaldığını bulmuş ve kalsiyum mekanizmasının HD üzerinde etkili olabileceğini savunmuştur [22]. Côté ve Parent, 2003 yılında yaptıkları çalışmada, maymunlarda PPN ve nucleus basalis'teki kolinerjik nöronların ikili immunhistokimyasal boyama yaparak kalbindin varlığını incelemişler, sonuçta PPN'deki kolinerjik nöronların kalbindinden yoksun olduğunu, nucleus basalis'teki kolinerjik nöronların ise kalbindin içerdiğini ortaya koymuşlardır [23].…”

Section: Discussionunclassified

Nucleus pedunculopontinus tegmenti’de nörokimyasal özelliklerin gelişimsel olarak incelenmesi

Kirazlı¹,

Şehirli²

2014

Marmara Medical Journal

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Loss of Matrix Calcium-Binding Protein-Containing Neurons in Huntington's Disease

Cited by 131 publications

References 24 publications

Heterogeneous Topographic and Cellular Distribution of Huntingtin Expression in the Normal Human Neostriatum

Heterogeneous Topographic and Cellular Distribution of Huntingtin Expression in the Normal Human Neostriatum

Differential localization of the GluR1 and GluR2 subunits of the AMPA-type glutamate receptor among striatal neuron types in rats

Nucleus pedunculopontinus tegmenti’de nörokimyasal özelliklerin gelişimsel olarak incelenmesi

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