Loss of CD19 expression in B‐cell neoplasms

Abstract

CD19 can now be detected in routine biopsy specimens. In contrast to the classical pan-B marker CD20, CD19 is not always strongly expressed in B-cell neoplasms. Furthermore, the lymphocytic and histiocytic (L&H) cells of lymphocyte predominant Hodgkin's disease (which express most B-cell-associated markers) commonly lack CD19.

Recent Insights into the Biology of Hodgkin's Lymphoma

“…In contrast to H/RS cells, LP cells retain most of their B cell programming; however, LP cells also show selective loss of the B cell phenotype such as down regulation of CD19, CD37, PAG and LCK (Dogan, A. et al, 2000;Masir, N. et al, 2006;Tedoldi, S. et al, 2007). The mechanism is not related to promoter methylation of the encoding genes (Tedoldi, S. et al, 2007).…”

Case study interpretation—New Orleans: Case 4

“…Things to look for include different expression of lineage-defining antigens, aberrant expression of antigens, and abnormal light scatter. While CD19 is thought to be a very useful lineage defining antigen for B cells, decreased or absent CD19 expression can be seen in B cell malignancies (1). Decreased or absent CD19 is more common in follicular lymphoma or DLBCL, but aberrant decrease or loss can occur in a variety of B lineage neoplasms (1,2).…”

“…While CD19 is thought to be a very useful lineage defining antigen for B cells, decreased or absent CD19 expression can be seen in B cell malignancies (1). Decreased or absent CD19 is more common in follicular lymphoma or DLBCL, but aberrant decrease or loss can occur in a variety of B lineage neoplasms (1,2). CD20 is also typically seen in mature B cells, though decreased CD20 expression is a classic immunophenotypic aberrancy of the neoplastic B cells comprising a CLL/SLL clone (3).…”

p53-mediated apoptosis prevents the accumulation of progenitor B cells and B-cell tumors

“…[53][54][55][56] Of particular interest, on the basis of the findings of this study, is to determine whether CD19-negative cases of human B-cell lymphomas are associated with p53 mutations.…”