Loss/Down-Regulation of Tumor Suppressor in Lung Cancer 1 Expression Is Associated With Tumor Progression and Is a Biomarker of Poor Prognosis in Ovarian Carcinoma

Yang, Guimei; He, Weipeng; Cai, Mengli; Luo, Fei; Kung, Hsiang‐Fu; Guan, Xin Yuan; Zeng, Yi-Xin; Xie, Dan

doi:10.1097/igc.0b013e31820fa168

Cited by 23 publications

(16 citation statements)

References 24 publications

(23 reference statements)

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“…TSLC1 deletions cause cell adhesion damage and disorders, leading to the growth, invasion and metastasis of tumours. Many studies have indicated that there is low or no expression of the TSLC1 protein in lung, nasopharyngeal, cervical, breast and other cancers . In the current study, we found that the intensity and rate of TSLC1 expression were lower in CA than in HC tissues.…”

Section: Discussionsupporting

confidence: 50%

Expression of Wnt‐1 and TSLC1 in condyloma acuminatum

et al. 2019

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Background. Despite its high contagiousness, high recurrence rate and potential for malignant transformation, effective treatments for condyloma acuminatum (CA) have not yet been developed. Accordingly, it is necessary to clarify the mechanisms underlying CA development. Aim. To investigate the expression and significance of the proteins Wnt-1 and TSLC1 in patients with CA and in normal foreskin controls. Methods. Wnt-1 and TSLC1 were assessed by immunohistochemistry in 45 patients with CA.Results. Positive expression rates of Wnt-1 and TSLC1 were 82.22% (37/45) and 37.78% (17/45), respectively, in CA tissues, and 29.17% (7/24) and 91.67% (22/24), respectively, in normal foreskin controls. Wnt-1 expression intensity in CA was markedly higher (positive to strongly positive) than that in normal controls (negative to weakly positive), whereas TSLC1 expression intensity ranged from weakly positive to positive in CA, and nearly strongly positive in the normal control group. The differences in the positive expression rate and expression intensity of Wnt-1 and TSLC1 between the two groups were statistically significant (P < 0.05). In addition, Wnt-1 and TSLC1 were negatively correlated. (r = À0.336, P < 0.05).Conclusions. Overexpression of Wnt-1 and low expression of TSLC1 may be associated with the growth of CA. These findings may provide a basis for the development of therapies to prevent recurrence or malignant transformation of CA.

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Section: Discussionsupporting

confidence: 50%

Expression of Wnt‐1 and TSLC1 in condyloma acuminatum

et al. 2019

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“…Numerous studies have implicated down-regulation of Cadm1 with poor patient prognosis [10], [12]–[14], [29], [30]; however, to the best of our knowledge no studies have investigated the mechanism responsible. Here we demonstrate that expression of Cadm1 in two independent cell lines resulted in either specific metastasis suppression or tumor suppression accompanied by a reduction in metastasis.…”

Section: Discussionmentioning

confidence: 99%

Cadm1 Is a Metastasis Susceptibility Gene That Suppresses Metastasis by Modifying Tumor Interaction with the Cell-Mediated Immunity

et al. 2012

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Metastasis is a complex process utilizing both tumor-cell-autonomous properties and host-derived factors, including cellular immunity. We have previously shown that germline polymorphisms can modify tumor cell metastatic capabilities through cell-autonomous mechanisms. However, how metastasis susceptibility genes interact with the tumor stroma is incompletely understood. Here, we employ a complex genetic screen to identify Cadm1 as a novel modifier of metastasis. We demonstrate that Cadm1 can specifically suppress metastasis without affecting primary tumor growth. Unexpectedly, Cadm1 did not alter tumor-cell-autonomous properties such as proliferation or invasion, but required the host's adaptive immune system to affect metastasis. The metastasis-suppressing effect of Cadm1 was lost in mice lacking T cell–mediated immunity, which was partially phenocopied by depleting CD8+ T cells in immune-competent mice. Our data show a novel function for Cadm1 in suppressing metastasis by sensitizing tumor cells to immune surveillance mechanisms, and this is the first report of a heritable metastasis susceptibility gene engaging tumor non-autonomous factors.

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“…TSLC1 protein contains three domains, extracellular, transmembrane and intracellular, which may correlate with its function. TSLC1 expression is down-regulated in many human cancers, such as laryngeal squamous carcinoma [3], uterine cervix cancer [4], ovarian carcinoma [5], breast cancer [6], nasopharyngeal carcinoma [7] and neuroblastoma [8]. It has been found that the lack of TSLC1 expression is closely related to the occurrence and progression of these cancers.…”

Section: Introductionmentioning

confidence: 99%

Effect of TSLC1 gene on growth and apoptosis in human esophageal carcinoma Eca109 cells

Liang¹,

Wang²,

Li³

et al. 2012

aoms

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IntroductionTo explore the effect of tumor suppressor in lung cancer 1 (TSLC1) on proliferation and apoptosis in esophageal cancer Eca109 cells.Material and methodsEca109 cells were divided into three groups: TSLC1 transfected group (TTG), mock group (MG) and untransfected group (UTG). The TTG and MG were transfected transiently with the pIRES2-EGFP-TSLC1 eukaryotic expression vector and pIRES2-EGFP vector respectively. The UTG was a blank control. The TSLC1 expression in TTG was analyzed with the fluorogram and RT-PCR method. Cell proliferation was measured with 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium (MTT) assay. Cell cycle was measured by flow cytometry (FCM). Cell apoptosis was detected by Annexin-V/PI double staining FCM.ResultsGreen color was found in TTG and MG. The band of TSLC1 mRNA of TTG was located at about 1400 bp by RT-PCR and agarose gel electrophoresis assay. The TSLC1 inhibited cell proliferation significantly in MTT assay, and the cell proliferation was slower in TTG than MG and UTG. After TSLC1 transfection, cell numbers increased in G0/G1 phase and decreased in S phase. Forty-eight hours after transfection, the apoptosis rate and death rate of TTG were higher than MG and UTG. Thus TSLC1 induced Eca109 cells to apoptosis.ConclusionsThe TSLC1 gene had a potent effect on cell proliferation inhibition, G1/S cell cycle arrest and induction of cell apoptosis in Eca109 cells.

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Loss/Down-Regulation of Tumor Suppressor in Lung Cancer 1 Expression Is Associated With Tumor Progression and Is a Biomarker of Poor Prognosis in Ovarian Carcinoma

Abstract: Decreased protein expression of the TSLC1 gene might be important in conferring a more aggressive behavior in ovarian carcinoma. Thus, TSLC1 may be used as an independent prognostic molecular marker for patients with ovarian carcinoma.

Cited by 23 publications

References 24 publications

Expression of Wnt‐1 and TSLC1 in condyloma acuminatum

Expression of Wnt‐1 and TSLC1 in condyloma acuminatum

Cadm1 Is a Metastasis Susceptibility Gene That Suppresses Metastasis by Modifying Tumor Interaction with the Cell-Mediated Immunity

Effect of TSLC1 gene on growth and apoptosis in human esophageal carcinoma Eca109 cells

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