Los parámetros espermáticos significativos que empeoran están asociados con la hipotrofia testicular en pacientes con varicocele de alto grado

Güzel, Özer; Aslan, Yılmaz; Balcı, Melih; Tuncel, Altuğ; Ünal, Burcu; Atan, Ali

doi:10.1016/j.acuro.2014.08.005

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…Testicular hypotrophy is associated with worse outcomes in terms of sperm quality,19 and endocrine impairments have been described in patients with varicocele 16. The significant increase in testicular volume observed in our study warrants further investigation, as catch-up growth might offer a better view of subsequent long-term improvement in the spermatogenetic function of the testes 16.…”

Section: Discussionsupporting

confidence: 49%

Effects of percutaneous varicocele repair on testicular volume: results from a 12-month follow-up

et al. 2019

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Varicocele is a common finding in men. Varicocele correction has been advocated for young patients with testicular hypotrophy, but there is a lack of morphofunctional follow-up data. We assessed whether percutaneous treatment of left varicocele is associated with testicular “catch-up growth” in the following 12 months by retrospectively reviewing data from an electronic database of 10 656 patients followed up in our clinic between 2006 and 2016. We selected all young adults (<35 years) with left varicocele who underwent percutaneous treatment, had a minimum of 12 months’ ultrasound imaging follow-up, and had no other conditions affecting testicular volume. One hundred and fourteen men (mean±standard deviation [s.d.] of age: 22.8 ± 5.4 years) met the inclusion and exclusion criteria. Left testicular hypotrophy (LTH), defined as a ≥20% difference between left and right testicular volume at baseline, was observed in 26 (22.8%) men. Participants with LTH (mean±s.d.: 14.5 ± 2.7 ml) had lower baseline testicular volume compared to those without LTH (mean±s.d.: 15.7 ± 3.8 ml; P = 0.032). Repeated measures mixed models showed a significant interaction between LTH and time posttreatment when correcting for baseline left testicular volume (β = 0.114, 95% confidence interval [CI]: 0.018–0.210, P = 0.020), resulting in a catch-up growth of up to 1.37 ml per year (95% CI: 0.221–2.516). Age at intervention was also associated with reduced testicular volume (−0.072 ml per year, 95% CI: −0.135–−0.009; P = 0.024). Percutaneous treatment of left varicocele in young adults with LTH can result in catch-up growth over 1 year of follow-up. The reproductive and psychological implications of these findings need to be confirmed in longer and larger prospective studies.

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Section: Discussionsupporting

confidence: 49%