In order to secure wireless communications, we consider the usage of physical-layer security (PLS) mechanisms (i.e., coding for secrecy mechanisms) combined with self-interference generation. We present a prototype implementation of a scrambled coding for secrecy mechanisms with interference generation by the legitimate receiver and the cancellation of the effect of self-interference (SI). Regarding the SI cancellation, four state-of-the-art algorithms were considered: Least mean square (LMS), normalized least mean square (NLMS), recursive least squares (RLS) and QR decomposition recursive least squares (QRDRLS). The prototype implementation is performed in real-world software-defined radio (SDR) devices using GNU-Radio, showing that the LMS outperforms all other algorithms considered (NLMS, RLS and QRDRLS), being the best choice to use in this situation (SI cancellation). It was also shown that it is possible to secure communication using only noise generation by the legitimate receiver, though a variation of the packet loss rate (PLR) and the bit error rate (BER) gaps is observed when moving from the fairest to an advantageous or a disadvantageous scenario. Finally, when noise generation was combined with the adapted scrambled coding for secrecy with a hidden key scheme, a noteworthy security improvement was observed resulting in an increased BER for Eve with minor interference to Bob.