Loop Between NLRP3 Inflammasome and Reactive Oxygen Species

Dominic, Abishai; Le, Nhat-Tu; Takahashi, Masafumi

doi:10.1089/ars.2020.8257

Cited by 81 publications

(61 citation statements)

References 99 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results suggest MALAT1 regulates signaling pathways involved in inflammatory response, including both the NF-κB and NLRP3 inflammasome pathways. In response to LPS induced endotoxemia, the innate immune system such as macrophages is activated through NF-κB pathway which activates NLRP3 inflammasome through two step signal processes where LPS activates NF-κB pathway followed by the activation of caspase1 leading to the processing of pro-IL-1β and assembly of NLRP3 inflammasome [ 52 ]. Indeed, our observations with the macrophage were consistent with this process where the classic NF-κB pathway was activated with high level of NLRP3 and IL-1β expression indicating the activation of the NLRP3 inflammasome.…”

Section: Discussionmentioning

confidence: 99%

“…Oxidative stress induced by the inflammatory responses goes hand-in-hand in sepsis [ 6 ]. In fact, it forms a positive feedback loop during the inflammatory responses [ 52 ]. In pathway analysis, we analyzed clinical sepsis patient samples and showed that the expression of MALAT1 was upregulated, which coincided with the activation of the oxidative stress and inflammatory pathways ( Fig.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ablation of long noncoding RNA MALAT1 activates antioxidant pathway and alleviates sepsis in mice

Chen

Tang

et al. 2022

Redox Biology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ablation of long noncoding RNA MALAT1 activates antioxidant pathway and alleviates sepsis in mice

Chen

Tang

et al. 2022

Redox Biology

View full text Add to dashboard Cite

“…Caspase-1, NLRP3, and ASC are known to be the important modulators in cell pyroptosis [ 29 , 30 ]. Meanwhile, IL-1 β is also a pyroptosis-related cytokine [ 31 , 32 ]. Caspase-1 was often upregulated during the onset of neuronal injury, suggesting that the promotion of pyroptosis might be associated with neuronal injury [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Quercetin Alleviates the Progression of Breast Cancer-Related Depression via Inhibiting the Pyroptosis and Promoting the Immune Response

Zhu

Yang

et al. 2022

Mediators of Inflammation

View full text Add to dashboard Cite

Background. Breast cancer-related depression (BCRD) seriously inhibits the life quality of patients with breast cancer. The Xiaoyao Kangai Jieyu Formula is known to inhibit the progression of depression. However, the detailed function of the Xiaoyao Kangai Jieyu Formula in BCRD remains unclear. Methods. Network pharmacology was constructed to assess the downstream target of the Xiaoyao Kangai Jieyu Formula in BCRD. In addition, the tail suspension test, sucrose preference test, and forced swimming test were used to test the symptom of depression in mice. Fluoro-Jade B staining was performed to observe the structure of neurons. RT-qPCR and western blot were applied to evaluate mRNA and protein levels. Besides, ELISA was performed to test the inflammatory responses and the immune response-related cytokines. Results. Quercetin was identified as the key component of the Xiaoyao Kangai Jieyu Formula. Quercetin significantly inhibited BCRD-induced neuron pyroptosis via downregulation of PYD and card domain containing (ASC), NLR family pyrin domain containing 3 (NLRP3), and caspase-1, and quercetin could reverse BCRD-caused inhibition of neuron viability. Quercetin significantly attenuated the symptom of BCRD in mice, and it could reverse the contents of 5-hydroxytryptamine (5-HT), dopamine (DA), and neutrophil elastase (NE) in mice. Moreover, quercetin could promote the immune responses in xenograft mice via upregulation of interleukin- (IL-) 2, interferon-γ (IFN-γ), and IL-10. Conclusion. Quercetin, the active ingredient of the Xiaoyao Kangai Jieyu Formula, effectively mitigated the progression of BCRD by inhibiting pyroptosis, promoting immune response, and improving serum metabolism.

show abstract

“…ROS have also been shown to promote the interaction between MINK1 and NLRP3 (Zhu et al, 2021 ). In addition, the ensuing inflammatory response recruits immune cells to increase ROS production, which suggests a feedback loop between ROS and the NLRP3 inflammasome (Franchi et al, 2009 ; Dominic et al, 2022 ). However, a few studies have reported that ROS are not necessary for this activation (Gabelloni et al, 2013 ; Gurung et al, 2015 ); therefore, the exact mechanism of mitochondrial dysfunction in the activation of the NLRP3 inflammasome requires further studies.…”

Section: Mechanisms Of Nlrp3 Inflammasome Activationmentioning

confidence: 99%

Focus on the Role of the NLRP3 Inflammasome in Multiple Sclerosis: Pathogenesis, Diagnosis, and Therapeutics

Cui

et al. 2022

Front. Mol. Neurosci.

View full text Add to dashboard Cite

Neuroinflammation is initiated with an aberrant innate immune response in the central nervous system (CNS) and is involved in many neurological diseases. Inflammasomes are intracellular multiprotein complexes that can be used as platforms to induce the maturation and secretion of proinflammatory cytokines and pyroptosis, thus playing a pivotal role in neuroinflammation. Among the inflammasomes, the nucleotide-binding oligomerization domain-, leucine-rich repeat- and pyrin domain-containing 3 (NLRP3) inflammasome is well-characterized and contributes to many neurological diseases, such as multiple sclerosis (MS), Alzheimer's disease (AD), and ischemic stroke. MS is a chronic autoimmune disease of the CNS, and its hallmarks include chronic inflammation, demyelination, and neurodegeneration. Studies have demonstrated a relationship between MS and the NLRP3 inflammasome. To date, the pathogenesis of MS is not fully understood, and clinical studies on novel therapies are still underway. Here, we review the activation mechanism of the NLRP3 inflammasome, its role in MS, and therapies targeting related molecules, which may be beneficial in MS.

show abstract

Loop Between NLRP3 Inflammasome and Reactive Oxygen Species

Cited by 81 publications

References 99 publications

Ablation of long noncoding RNA MALAT1 activates antioxidant pathway and alleviates sepsis in mice

Ablation of long noncoding RNA MALAT1 activates antioxidant pathway and alleviates sepsis in mice

Quercetin Alleviates the Progression of Breast Cancer-Related Depression via Inhibiting the Pyroptosis and Promoting the Immune Response

Focus on the Role of the NLRP3 Inflammasome in Multiple Sclerosis: Pathogenesis, Diagnosis, and Therapeutics

Contact Info

Product

Resources

About