Quercetin Alleviates the Progression of Breast Cancer-Related Depression via Inhibiting the Pyroptosis and Promoting the Immune Response

Zhu, Qing; Yang, Lei; Yang, Hui; Han, Yuanshan; Chen, Yun; He, Ying

doi:10.1155/2022/8011988

Cited by 19 publications

(14 citation statements)

References 42 publications

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“…57 Among the SBF flavonoids, quercetin has been reported to have anti-depression ability. For example, it was reported that quercetin relieved the depressive-like symptoms in LPS-induced mice via the regulation of the PI3K/AKT/NF-κB and CREB/BDNF pathways, 58 restored breast cancer-related depression by suppressing cell pyroptosis and promoting the immune response, 59 as well as regulated the inflammatory, oxidative stress and 5-HT levels in vivo . 60 Meanwhile, isorhamnetin and kaempferol have functions in the treatment of brain defects.…”

Section: Discussionmentioning

confidence: 99%

Flavonoids from Seabuckthorn (Hippophae rhamnoides L.) restore CUMS-induced depressive disorder and regulate the gut microbiota in mice

Xia,

Gao,

Zhu

et al. 2023

Food Funct.

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Section: Discussionmentioning

confidence: 99%

Flavonoids from Seabuckthorn (Hippophae rhamnoides L.) restore CUMS-induced depressive disorder and regulate the gut microbiota in mice

Xia,

Gao,

Zhu

et al. 2023

Food Funct.

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“…In addition to the medicines mentioned in the previous section, some potential agents have also been reported to exert roles through other anti-inflammatory mechanisms. Isoliquiritin ( Li, Y. et al, 2021 ), pinocembrin ( Yang et al, 2022 ), pilose antler peptide ( Hu et al, 2022 ), quercetin ( Zhu et al, 2022 ), etc. ameliorated depression by suppressing pyroptosis in animal models.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory pathophysiological mechanisms implicated in postpartum depression

2022

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Postpartum Depression (PPD) is a serious psychiatric disorder of women within the first year after delivery. It grievously damages women’s physical and mental health. Inflammatory reaction theory is well-established in depression, and also has been reported associated with PPD. This review summarized the inflammatory pathophysiological mechanisms implicated in PPD, including decreased T cell activation, increased proinflammatory cytokines secretion, active kynurenine pathway, and initiated NLRP3 inflammasome. Clinical and preclinical research are both gathered. Potential therapeutical alternatives targeting the inflammatory mechanisms of PPD were introduced. In addition, this review briefly discussed the differences of inflammatory mechanisms between PPD and depression. The research of inflammation in PPD is limited and seems just embarking, which indicates the direction we can further study. As a variety of risky factors contribute to PPD collectively, therapy for women with PPD should be comprehensive, and clinical heterogeneity should be taken into consideration. As PPD has a predictability, early clinical screening and interventions are also needed. This review aims to help readers better understand the inflammatory pathological mechanisms in PPD, so as to identify biomarkers and potential therapeutic targets in the future.

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“…Currently, quercetin has not been reported to possess anti-tumor effects through the regulation of pyroptosis. However, it has been investigated that the specific role of quercetin in breast cancer-related depression (BCRD), in which the inhibition of pyroptosis and promotion of immune response are the main mechanisms for effectively mitigating the progression of BCRD ( Zhu et al, 2022 ). In this study, quercetin partially reversed the pyroptosis on LPS-cultured 4T1 cells in vitro , as evidenced markedly by upregulating the card structural domain, NLR family pyrin structural domain (NLRP3), and Caspase-1.…”

Section: Therapeutic Mechanisms Of Quercetin Targeting Non-apoptotic ...mentioning

confidence: 99%

Targeting of non-apoptotic cancer cell death mechanisms by quercetin: Implications in cancer therapy

Yang

Xu²,

Tang³

et al. 2022

Front. Pharmacol.

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The ultimate goal of cancer treatment is to kill cancer cells, based on the use of various therapeutic agents, such as chemotherapy, radiotherapy, or targeted therapy drugs. Most drugs exert their therapeutic effects on cancer by targeting apoptosis. However, alterations in apoptosis-related molecules and thus assisting cells to evade death, eventually lead to tumor cell resistance to therapeutic drugs. The increased incidence of non-apoptotic cell death modes such as induced autophagy, mitotic catastrophe, senescence, and necrosis is beneficial to overcoming multidrug resistance mediated by apoptosis resistance in tumor cells. Therefore, investigating the function and mechanism of drug-induced non-apoptotic cell death modes has positive implications for the development of new anti-cancer drugs and therapeutic strategies. Phytochemicals show strong potential as an alternative or complementary medicine for alleviating various types of cancer. Quercetin is a flavonoid compound widely found in the daily diet that demonstrates a significant role in inhibiting numerous human cancers. In addition to direct pro-tumor cell apoptosis, both in vivo and in vitro experiments have shown that quercetin exerts anti-tumor properties by triggering diverse non-apoptotic cell death modes. This review summarized the current status of research on the molecular mechanisms and targets through which quercetin-mediated non-apoptotic mode of cancer cell death, including autophagic cell death, senescence, mitotic catastrophe, ferroptosis, necroptosis, etc.

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Quercetin Alleviates the Progression of Breast Cancer-Related Depression via Inhibiting the Pyroptosis and Promoting the Immune Response

Cited by 19 publications

References 42 publications

Flavonoids from Seabuckthorn (Hippophae rhamnoides L.) restore CUMS-induced depressive disorder and regulate the gut microbiota in mice

Flavonoids from Seabuckthorn (Hippophae rhamnoides L.) restore CUMS-induced depressive disorder and regulate the gut microbiota in mice

Inflammatory pathophysiological mechanisms implicated in postpartum depression

Targeting of non-apoptotic cancer cell death mechanisms by quercetin: Implications in cancer therapy

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