Looking into the virulence of<i>Candida parapsilosis</i>

Bader, Oliver

doi:10.4161/viru.28955

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…The transition from yeast to pseudohypha growth promotes C. parapsilosis invasion through several mechanisms, including disruption of host cells and tissues, penetration of tissues, and formation of biofilms (18,19).…”

Section: Discussionmentioning

confidence: 99%

Candida spp. Carrying in Post-exodontia Sutures of Retained Third Molars

Puia

Jewtuchowicz

Perez

et al. 2023

Jentashapir J Cell Mol Biol

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Background: When sutures are removed, bacteriemia and infections of odontological origin may cause bacterial endocarditis and other diseases. Objectives: This study aimed to investigate the colonization by Candida species in sutures after extraction of retained third molars as well as to examine the influence of the position of the dental piece and the material used in sutures. Methods: A total of 56 male and female patients aged 21 - 55 years and with retained lower third molars were examined. Suture threads were removed a week later, and yeasts were isolated and grown in differential chromogenic medium and in sabouraud dextrose agar. Results: Out of 56 patients, 16 patients (28.57%) were found to carry some species of the yeast of genus Candida. The predominant species was C. albicans (23.20%), followed by C. parapsilosis complex (5.40%). Although 19 out of 33 patients (57,58%) tested negative, the yeasts were detected in the vertical position of the teeth of 14 patients (42.42%). The horizontal and mesioangular position carried the yeasts in 12.50, and 8.33% of the patients, respectively, while the distoangular position was yeast-negative. No significant difference was observed among the different positions. Yeasts were detected in 9 out of 26 patients (34.61%) with nylon threads and in 7 out of 30 patients (23.33%) with silk threads. According to the results from statistical analysis, no significant difference was found between the materials. Conclusions: The post-extraction suture threads of retained third molars were found to carry some species of the genus Candida. The species C. albicans was the predominant species, followed by C. parapsilosis. The vertical position of the molar tended to carry yeasts to a greater degree than the horizontal and mesiangular one, although it was not statistically significant. No significant differences were detected between nylon and silk suture threads either.

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Section: Discussionmentioning

confidence: 99%

Candida spp. Carrying in Post-exodontia Sutures of Retained Third Molars

Puia

Jewtuchowicz

Perez

et al. 2023

Jentashapir J Cell Mol Biol

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“…Phospholipase helps to maintain the function of the fungal cell membrane, and contributes to the invasion of host tissue by hydrolyzing the ester linkages in glycerophospholipids (Schaller et al, 2005). Lipase promotes the survival of fungal cells in macrophages and mitigates the inflammatory response of the host (Bader, 2014). Furthermore, the fungal cells secrete hemolysin, which lyses red blood cells, and sequester the iron to facilitate hyphae invasion and establish disseminated infection in the host (Chin et al, 2013).…”

Section: Introductionmentioning

confidence: 96%

Significance of hyphae formation in virulence of Candida tropicalis and transcriptomic analysis of hyphal cells

Jiang

Zhang

et al. 2016

Microbiological Research

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Recently, the proportion of Candida tropicalis in clinical isolates has significantly increased. Some C. tropicalis strains colonize the skin or mucosal surfaces as commensals; others trigger invasive infection. To date, the pathogenicity of C. tropicalis has not been thoroughly researched. This study reports several virulence factors, including biofilm and hyphae formation, proteinase, phospholipase, lipase and hemolytic activity, in 52 clinical isolates of C. tropicalis collected from five hospitals in four provinces of China. Some C. tropicalis tended to produce more hyphae than others in the same circumstance. Six C. tropicalis strains with different morphologies were injected into mice via the tail vein, and the survival proportions and fungal burdens of the strains were evaluated. Hyphal production by C. tropicalis was associated with stronger virulence. RNA sequencing revealed that C. tropicalis with more hyphae up-regulated several genes involved in morphological differentiation and oxidative response, including IF2, Atx1, and Sod2. It appears that hyphal formation plays a vital role in the pathogenicity of C. tropicalis, and interacts with the oxidative stress response to strengthen the organism's virulence.

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Candida parapsilosis isolates from burn wounds can penetrate an acellular dermal matrix

Okuno

Jarros

Mendonca

et al. 2018

Microbial Pathogenesis

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We isolated and identified yeasts from burn wounds and evaluated the ability of Candida parapsilosis isolates from burn wounds to penetrate an acellular dermal matrix (ADM). A prospective study was conducted with patients from the burn treatment center of North Paraná University Hospital in Londrina, Brazil from February 2015 to January 2016. Yeast cultures were obtained from the tissue of burn wounds that had been debrided and cleansed with 2% chlorhexidine. After identification and confirmation of the purity of the culture, the yeasts were placed on ADM fragments and incubated for three or seven days. During the study period, 273 patients were treated, and 36 of these patients fulfilled the inclusion criteria and provided samples for culture. Yeasts were isolated in 19.44% (n = 7) of the cultures, and the following species were identified: C. parapsilosis (57.1%), C. albicans (28.6%), and C. glabrata (14.3%). C. parapsilosis, the most frequent species, was chosen for the ADM tests. We demonstrated active penetration of the ADM by the yeast isolates from burn wounds. C. parapsilosis grew on ADM and penetrated the matrix, indicating that this yeast, which is common in skin and cutaneous wounds, has the potential to colonize and pass through ADM, a medical device that is frequently used to dress and regenerate burn wounds.

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Looking into the virulence ofCandida parapsilosis

Cited by 3 publications

References 23 publications

Candida spp. Carrying in Post-exodontia Sutures of Retained Third Molars

Candida spp. Carrying in Post-exodontia Sutures of Retained Third Molars

Significance of hyphae formation in virulence of Candida tropicalis and transcriptomic analysis of hyphal cells

Candida parapsilosis isolates from burn wounds can penetrate an acellular dermal matrix

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