Look-alike humans identified by facial recognition algorithms show genetic similarities

Joshi, Ricky S.; Rigau, Maria; García-Prieto, Carlos A.; Moura, Manuel Castro de; Piñeyro, David; Morán, Sebastian; Dávalos, Verónica; Carrión, Pablo; Ferrando-Bernal, Manuel; Olalde, Ïñigo; Lalueza‐Fox, Carles; Navarro, Arcadi; Fernández-Tena, Carles; Aspandi, Decky; Sukno, Federico M.; Binefa, Xavier; Valencia, Alfonso; Esteller, Manel

doi:10.1016/j.celrep.2022.111257

Cited by 14 publications

(7 citation statements)

References 56 publications

(64 reference statements)

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“…In addition, given the large number of mouse models in translational research, a mouse DNA microarray has been developed that covers more than 285,000 CpG sites of the mouse genome [ 12 ]. These methylation microarrays have been widely used by the research community, not only for The Cancer Genome Atlas (TCGA) methylation studies [ 13 ], but also for deciphering the DNA methylome in genetic diseases [ 14 ], ageing [ 15 ], interindividual variability [ 16 , 17 ] and molecular epidemiology projects [ 18 ]. CpG probes map CpG-rich regions, gene promoters and cis-regulatory elements, mainly in the 850K array.…”

Section: Introductionmentioning

confidence: 99%

Validation of the new EPIC DNA methylation microarray (900K EPIC v2) for high-throughput profiling of the human DNA methylome

et al. 2023

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DNA methylation, one of the best characterized epigenetic marks in the human genome, plays a pivotal role in gene transcription regulation and other biological processes in humans. On top of that, the DNA methylome undergoes profound changes in cancer and other disorders. However, large-scale and population-based studies are limited by high costs and the need for considerable expertise in data analysis for whole-genome bisulphite-sequencing methodologies. Following the success of the EPIC DNA methylation microarray, the newly developed Infinium HumanMethylationEPIC version 2.0 (900K EPIC v2) is now available. This new array contains more than 900,000 CpG probes covering the human genome and excluding masked probes from the previous version. The 900K EPIC v2 microarray adds more than 200,000 probes covering extra DNA cis-regulatory regions such as enhancers, super-enhancers and CTCF binding regions. Herein, we have technically and biologically validated the new methylation array to show its high reproducibility and consistency among technical replicates and with DNA extracted from FFPE tissue. In addition, we have hybridized primary normal and tumoural tissues and cancer cell lines from different sources and tested the robustness of the 900K EPIC v2 microarray when analysing the different DNA methylation profiles. The validation highlights the improvements offered by the new array and demonstrates the versatility of this updated tool for characterizing the DNA methylome in human health and disease.

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Section: Introductionmentioning

confidence: 99%

Validation of the new EPIC DNA methylation microarray (900K EPIC v2) for high-throughput profiling of the human DNA methylome

et al. 2023

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“…There are times when events in occupational, academic or recreational schedules overlap, forcing a choice between them. MZ twins are a unique exception to this general rule, although recent interest in studying and finding one's doppelgänger (look-alike) may make MZ twins' physical advantage less exceptional (Joshi et al, 2022;Segal et al, 2018). In 2005, Julian Castro, then candidate for mayor of San Antonio, and former U.S. Secretary of Housing and Urban Development, was unable to attend a city parade to be attended by his constituents (News, 2005).…”

Section: Conveniencementioning

confidence: 99%

Twins Standing in for Co-Twins: Explanation and Speculation/Twin Research Reviews: Single v. Multiple Embryo Transfer; Neurimaging of Twins with Periventricular Nodular Heterotopia; Twin Dietary Study; New Hungarian Text on Twins/Human Interest: Valedictorian and Salutatorian Twins; Twin Mother at Age Seventy; Twins Reunited by Tiktok; New Film on Twins with Selective Mutism; Becoming Twin Doctors

Segal

2024

Twin Res Hum Genet

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An overview of circumstances in which twins take the place of their co-twin is presented. Various explanations and speculations are proposed for understanding twins’ willingness to do so in certain situations. This section is followed by reviews of timely twin research, namely single versus multiple embryo transfer; neurimaging of twins with periventricular nodular heterotopia; a twin dietary comparison; and a new book of twin-related readings from Hungary. The final portion of this article concerns human interest stories that both inform and entertain. They involve valedictorian and salutatorian twins; a mother delivering twins at age seventy; twins reunited by TikTok; a new film about twins with selective mutism; and twins becoming doctors.

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“…Lippert et al were able to some extent to re-identify individuals in whole-genome sequencing data set by predicting visual traits, including eye and skin colour [39]. Subsequently, Joshi et al have demonstrated that unrelated individuals with similar faces share similar genotypes of common 19277 SNVs [40]. This particular research provides evidence that human face structure is determined based on the individual's SNVs landscape.…”

Section: Personal Data Protectionmentioning

confidence: 99%

Genetic data protection as an indispensable element of genomic medicine development

Madej¹,

Karpiński²,

Akopyan³

et al. 2023

Polish Archives of Internal Medicine

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The immense progress in molecular biology, observed in the last decades has led to a fundamental change in our understanding of the etiology of human diseases. The whole genome analyses, both DNA sequencing and microarray Comparative Genomic Hybridization allowed for identification of previously unidentified diseases and syndromes. Therefore, in difficult-to-diagnose cases, clinical diagnosis is being replaced by molecular diagnosis (molecular dysmorphology, genomic medicine). For both scientific development of human genetics and clinical characteristics of rare genetic diseases, the construction and sharing of internationally available large databases has become crucial. However, genetic data has to be considered on the individual level too, and therefore it has to be treated as sensitive personal data. The context of ethical and legal risks involved in genetic testing has been long analyzed, although recognition of personal data protection issues is a more recent topic. The respective legal acts and protective measures should take into account several different aspects. The paper explores major benefits and risks involved in international sharing of vast databases of genetic material and presents legal provisions applied in the European Union, the USA and China. This latter part is based on the respective acts themselves, as well as on analyses and commentaries by other scholars.

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Look-alike humans identified by facial recognition algorithms show genetic similarities

Cited by 14 publications

References 56 publications

Validation of the new EPIC DNA methylation microarray (900K EPIC v2) for high-throughput profiling of the human DNA methylome

Validation of the new EPIC DNA methylation microarray (900K EPIC v2) for high-throughput profiling of the human DNA methylome

Genetic data protection as an indispensable element of genomic medicine development

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