Loofah-chitosan and poly (−3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) based hydrogel scaffolds for meniscus tissue engineering applications

Baysan, Gizem; Güneş, Oylum Çolpankan; Akokay, Pınar; Hüsemoğlu, R. Buğra; Ertugruloglu, Pinar; Albayrak, Aylin Ziylan; Çeçen, Berivan; Havıtçıoğlu, Hasan

doi:10.1016/j.ijbiomac.2022.09.031

Cited by 11 publications

(3 citation statements)

References 47 publications

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“…Compared with meniscus repair materials, the current research is more inclined to manufacture integrated materials for restoration and regeneration. Recent study of Baysan et al revealed that a new type of hydrogel composite scaffold made of chitosan, loofah mat, and poly (-3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofibers is a promising material for engineering meniscus tissue ( Baysan et al, 2022 ). Figure 2 and Table 2 present the typical investigations of meniscus rehabilitation hydrogels in meniscus repair and their outcomes.…”

Section: Meniscus Rehabilitation Hydrogelsmentioning

confidence: 99%

“…Of these, 149 articles were carefully read and made into this review. During the subsequent overhaul, four newly published articles ( Baysan G et al, 2022 ; Herrera Millar et al, 2022 ; Kim and Bonassar, 2022 ; Zihna et al, 2022 ) were added to this review. Next, the various functionalized hydrogels for meniscus repair in the published literature will be overviewed, and the characteristics and applications of these hydrogels will be briefly introduced.…”

Section: Introductionmentioning

confidence: 99%

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Applications and prospects of different functional hydrogels in meniscus repair

Jin

Liu

Chen

et al. 2022

Front. Bioeng. Biotechnol.

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The meniscus is a kind of fibrous cartilage structure that serves as a cushion in the knee joint to alleviate the mechanical load. It is commonly injured, but it cannot heal spontaneously. Traditional meniscectomy is not currently recommended as this treatment tends to cause osteoarthritis. Due to their good biocompatibility and versatile regulation, hydrogels are emerging biomaterials in tissue engineering. Hydrogels are excellent candidates in meniscus rehabilitation and regeneration because they are fine-tunable, easily modified, and capable of delivering exogenous drugs, cells, proteins, and cytokines. Various hydrogels have been reported to work well in meniscus-damaged animals, but few hydrogels are effective in the clinic, indicating that hydrogels possess many overlooked problems. In this review, we summarize the applications and problems of hydrogels in extrinsic substance delivery, meniscus rehabilitation, and meniscus regeneration. This study will provide theoretical guidance for new therapeutic strategies for meniscus repair.

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Section: Meniscus Rehabilitation Hydrogelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Applications and prospects of different functional hydrogels in meniscus repair

Jin

Liu

Chen

et al. 2022

Front. Bioeng. Biotechnol.

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“…Tissue engineering has been proven to be an advanced therapeutic strategy for meniscus repair. 3 The link between the immune system or immune microenvironment and tissue regeneration has been gradually uncovered in recent years. Studies have shown that there may be a significant inflammatory response in the knee joint following meniscal injury.…”

Section: Introductionmentioning

confidence: 99%

STS loaded PCL-MECM based hydrogel hybrid scaffolds promote meniscal regeneration via modulating macrophage phenotype polarization

Yin

Chen

et al. 2023

Biomater. Sci.

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Elderberry (Sambucus nigra) and hawthorn (Crataegus oxyacantha) extract additives in carboxymethyl chitosan scaffolds for osteochondral tissue engineering applications

Baysan,

Yilmaz,

Husemoglu

et al. 2024

J of Applied Polymer Sci

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Advancements in new treatment methods are becoming increasingly necessary due to a longer life expectancy, particularly in the field of osteochondral tissue engineering. In the present study, osteochondral tissue scaffolds with/without the addition of hawthorn or elderberry extracts were fabricated. Poly(ethylene glycol) diglycidyl ether (PEGDE) cross‐linked carboxymethyl chitosan hydrogel scaffold matrix was used as a control group. The addition of the plant extracts resulted in open porous structures with pore sizes around 100–450 μm and elastic modulus between 0.5 and 0.7 MPa, biomimicking the osteochondral tissue. Scaffolds containing either plant extract showed a high swelling tendency (1500–1750%) and a delayed release of the extracts after a week. Furthermore, the weight loss of the scaffolds after an enzymatic degradation for 56 days was ~30%. In addition, in vitro biocompatibility analyses were performed using bone marrow‐derived mesenchymal stem cells confirming non‐cytotoxicity for all the scaffold types. Biochemical assessment of alkaline phosphatase activity and glycosaminoglycan content yielded results consistent with osteochondral scaffold requirements. Finally, immunohistochemical analyses indicated that the plant extract addition, especially elderberry, increased collagen type I and type II formation. As a result, the addition of both hawthorn and elderberry extracts is a promising approach to osteochondral tissue regeneration.

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Loofah-chitosan and poly (−3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) based hydrogel scaffolds for meniscus tissue engineering applications

Cited by 11 publications

References 47 publications

Applications and prospects of different functional hydrogels in meniscus repair

Applications and prospects of different functional hydrogels in meniscus repair

STS loaded PCL-MECM based hydrogel hybrid scaffolds promote meniscal regeneration via modulating macrophage phenotype polarization

Elderberry (Sambucus nigra) and hawthorn (Crataegus oxyacantha) extract additives in carboxymethyl chitosan scaffolds for osteochondral tissue engineering applications

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